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Sparfloxacin compound combination preparation and preparation method thereof

The technology of sparfloxacin and composition is applied in the field of sparfloxacin composition preparation and preparation thereof, which can solve the problems of unsatisfactory dissolution rate of capsules and tablets, and achieve better dissolution effect, good stability, Effects that are easy to implement

Inactive Publication Date: 2012-08-15
广东好药多医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Since sparfloxacin is insoluble in water, the dissolution rate of existing capsules and tablets is not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Sparfloxacin capsules of the present invention can be prepared by various suitable methods of hard capsule preparations, preferably by the following preparation method:

[0036] Raw materials and excipients: sparfloxacin 100g, arginine 30g, citrulline 15g, microcrystalline cellulose 20g, pregelatinized starch 40g, lactose 40g, appropriate amount of 5% povidone K30 solution and stearic acid Magnesium 1 g.

[0037] The preparation process is to crush the raw and auxiliary materials separately, pass through a 60-100 mesh sieve, mix evenly sparfloxacin, arginine, citrulline, microcrystalline cellulose, pregelatinized starch, and lactose, and then use 5% polyvinyl The ketone K30 solution is made into a soft material, granulated with a 20-mesh sieve, the granules are dried with hot air, and the granules are sized, and then the prescribed amount of magnesium stearate is added, mixed evenly, the content of the intermediate is detected, and the amount of each grain is calculated...

Embodiment 2

[0042] A kind of sparfloxacin capsule of the embodiment of the present invention is made by following preparation method:

[0043] Raw materials and excipients: 200g sparfloxacin, 60g arginine, 30g citrulline, 20g microcrystalline cellulose, 40g pregelatinized starch, 40g lactose, appropriate amount of 5% povidone K30 solution and stearic acid Magnesium 1 g.

[0044] The preparation process adopts the method of Example 1 to prepare 1000 sparfloxacin capsules.

Embodiment 3

[0046] The embodiment of the present invention is a kind of sparfloxacin capsule, the raw materials of which are sparfloxacin 100g, arginine 60g, citrulline 30g, adopt the method of Example 1 (other conventional capsule preparation methods can also be used) Granulate 1000 grains.

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PUM

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Abstract

The invention provides a Sparfloxacin compound combination preparation comprising Sparfloxacin, arginine and citruline, and the weight of the citruline is half that of the arginine. The Sparfloxacin compound combination preparation is good in quality stability and dissolving effect and suitable for wide crowds. The invention further provides a preparation method of Sparfloxacin capsules and Sparfloxacin tablets, which is simple in process and easy to implement.

Description

technical field [0001] The invention relates to a composition preparation, in particular to a sparfloxacin composition preparation and a preparation method thereof. Background technique [0002] Sparfloxacin (sparfloxacin) is a new quinolone broad-spectrum antibiotic, which has broad antibacterial spectrum, strong antibacterial activity, good absorption, high tissue concentration, long half-life and other characteristics. All have good antibacterial effect. It is suitable for the treatment of various infections caused by gram-positive and negative aerobic bacteria, anaerobic bacteria, chlamydia, mycoplasma, gonorrhoeae and mycobacterium tuberculosis. There are few drug interactions and adverse reactions, and it is widely used in clinical practice. The analysis of its clinical efficacy is reported as follows. Treatment of acute bacterial infection, treatment of lower respiratory tract bacterial infection, treatment of venereal prostatitis, treatment of gonorrhea combined wi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/496A61K31/198A61K9/48A61K9/20A61P31/04
Inventor 吴秋萍
Owner 广东好药多医药有限公司
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