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Production method of compound sodium lactate glucose injection capable of preventing yellowing

A technology of glucose injection and compound sodium lactate, applied in the field of medicine, can solve the problems of immature production process conditions, low product qualification rate, unstable quality, etc., and achieve the effects of ensuring drug quality, preventing yellowing and improving qualification rate.

Active Publication Date: 2012-08-22
河南合智医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a product with stable quality of liquid medicine and low product pass rate in view of the immature production process conditions of sodium lactate glucose injection in polypropylene bottles, yellowing of the liquid medicine in the finished product, unstable quality and low pass rate of the product. Production method of compound sodium lactate glucose injection preventing yellowing with high qualified rate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] A kind of compound sodium lactate glucose injection production method that prevents yellowing, comprises the following steps:

[0015] 1) Concentrated formulation: a. Add 300 liters of water for injection into the concentrated formulation tank, open the cooling cycle water valve of the concentrated formulation tank to lower the temperature of the concentrated formulation tank to 55°C, turn on the concentrated formulation tank and add 50 kg of glucose, 6 After one kilogram of sodium chloride, 0.3 kilogram of potassium chloride, and 0.2 kilogram of calcium chloride are completely dissolved, add a sodium lactate solution with a mass fraction of 11.2% until the mass of sodium lactate is 3.1 kilograms, then add 15 kilograms of activated carbon, and keep stirring for 10 minutes ;

[0016] b. Turn on the circulating pump of the thick matching tank, circulate and filter the activated carbon in the thick matching tank through the coarse filter equipped with a titanium filter rod...

Embodiment 2

[0022] A kind of compound sodium lactate glucose injection production method that prevents yellowing, comprises the following steps:

[0023] 1) Concentrated formulation: a. Add 350 liters of water for injection into the concentrated formulation tank, open the cooling cycle water valve of the concentrated formulation tank to lower the temperature of the concentrated formulation tank to 60°C, turn on the concentrated formulation tank and add 50 kg of glucose, 6 After one kilogram of sodium chloride, 0.3 kilogram of potassium chloride, and 0.2 kilogram of calcium chloride are completely dissolved, add a sodium lactate solution with a mass fraction of 11.5% until the mass of sodium lactate is 3.1 kilograms, then add 25 kilograms of activated carbon, and keep stirring for 12 minutes ;

[0024] b. Turn on the circulating pump of the thick matching tank, circulate and filter the activated carbon in the thick matching tank through the coarse filter equipped with a titanium filter rod...

Embodiment 3

[0030] A kind of compound sodium lactate glucose injection production method that prevents yellowing, comprises the following steps:

[0031] 1) Concentrated formulation: a. Add 400 liters of water for injection into the concentrated formulation tank, open the cooling circulation water valve of the concentrated formulation tank to lower the temperature of the concentrated formulation tank to 65°C, turn on the concentrated formulation tank and add 50 kg of glucose, 6 One kilogram of sodium chloride, 0.3 kilogram of potassium chloride, 0.2 kilogram of calcium chloride, after completely dissolving, then add the sodium lactate solution that the mass fraction is 12% to the quality of sodium lactate is 3.1 kilograms, then add 40 kilograms of activated carbon, keep stirring for 15 minutes ;

[0032] b. Turn on the circulating pump of the thick matching tank, circulate and filter the activated carbon in the thick matching tank through the coarse filter equipped with a titanium filter ...

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Abstract

The invention belongs to the technical field of medicine, and in particular relates to a production method of a compound sodium lactate glucose injection capable of preventing yellowing. The invention aims to solve the problems of immature production process conditions, yellowing of liquid medicine, instable quality, low product percent of pass and the like of polypropylene bottled sodium lactateglucose injection. The invention has the technical scheme that: the production method of the compound sodium lactate glucose injection capable of preventing yellowing comprises the following steps of: firstly, dissolving a certain amount of raw materials completely in a thick preparation tank, adding active carbon, then cyclically filtering the active carbon, transferring the solution into a thinpreparation tank for quantification; sterilizing in a high-temperature superheated water shower bath mode; and performing lamp detection, leak detection and packing to obtain the compound sodium lactate glucose injection. The invention changes the sequence of adding the raw materials such as glucose, sodium chloride, potassium chloride, sodium lactate and calcium chloride, simultaneously changes the production process conditions, prevents the product liquid medicine from yellowing, ensures stable medicine quality and improves the product percent of pass.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for producing compound sodium lactate glucose injection for preventing yellowing. Background technique [0002] At present, most of the compound sodium lactate glucose injections are packaged in glass bottles. Because glass bottles are often damaged in clinical medication due to misoperation by nurses or other reasons, there are glass shavings in the liquid medicine. , glass shavings will enter the human body, causing additional harm to patients; in addition, glass bottles often break due to collisions during transportation; therefore, the compound sodium lactate glucose injection in polypropylene bottles is very popular among consumers, but due to The production process of polypropylene bottled sodium lactate glucose injection is immature, and the finished product has problems such as yellowing of the liquid medicine, which in turn leads to unstable quality...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/19A61K31/7004A61K33/14A61K9/08
Inventor 张润成
Owner 河南合智医药科技有限公司
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