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Three-dimensional copper oxide nanometer flower-based chip enzyme-free glucose sensor electrode as well as preparation method and application thereof

A technology of glucose sensor and copper oxide, which is applied in instruments, scientific instruments, and material analysis through electromagnetic means, can solve the problems of not easy to respond to current, slow overall dynamics, low sensitivity, etc., and achieve strong anti-interference ability and linearity The effect of wide range and good application prospect

Inactive Publication Date: 2011-08-17
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Researchers have conducted in-depth studies on the kinetics and mechanism of electrochemical oxidation of glucose at bare platinum electrodes and found that there are three defects in the process of oxidation of glucose on the surface of platinum electrodes: one is that the overall kinetics of this oxidation is too slow So that it is not easy to generate a significant response current; the second is that the surface of the platinum electrode is very easy to adsorb the intermediate substances produced in the process of glucose oxidation, thereby greatly reducing its activity; the third is the presence of ascorbic acid, uric acid and p-acetylamino in the receptor Influenced by interfering substances such as phenol, the sensitivity is not high

Method used

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  • Three-dimensional copper oxide nanometer flower-based chip enzyme-free glucose sensor electrode as well as preparation method and application thereof
  • Three-dimensional copper oxide nanometer flower-based chip enzyme-free glucose sensor electrode as well as preparation method and application thereof
  • Three-dimensional copper oxide nanometer flower-based chip enzyme-free glucose sensor electrode as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take a copper foil sheet with a thickness of 0.2mm, rinse it repeatedly with distilled water and deionized water, and put it in an oven to dry after ultrasonication. Prepare a KOH solution with a mass fraction of 2%, let it stand for 10 minutes, take the prepared solution in a beaker, place it in a constant temperature water bath, adjust the temperature to 30°C, put the cleaned and dried copper foil in the beaker, and let it stand After standing for 3 days, the samples were removed, rinsed slowly with distilled water and again with deionized water, and dried. Observing the dried three-dimensional copper oxide nanoflowers under a scanning electron microscope, it can be seen that the three-dimensional copper oxide nanoflowers are evenly distributed on the electrode surface, and the diameter of a single nanoflower is 10-20 μm. Such as figure 1 shown.

Embodiment 2

[0023] Take a copper foil sheet with a thickness of 0.3mm, wash it repeatedly with distilled water and deionized water, and put it in an oven to dry after ultrasonication. Configure a KOH solution with a mass fraction of 3%, let it stand for 10 minutes, take the prepared solution in a beaker, place it in a constant temperature water bath, adjust the temperature to 40°C, put the cleaned and dried copper foil in the beaker, and let it stand After 6 days, the samples were removed, rinsed slowly with distilled water and again with deionized water, and dried. Observing the dried three-dimensional copper oxide nanoflowers under a scanning electron microscope, it can be seen that the three-dimensional copper oxide nanoflowers are evenly distributed on the electrode surface, the nanoflowers are closely packed, and the shape of a single nanoflower is clear. The diameter of a single nanoflower is between 10 -20 μm. Such as figure 2 shown.

[0024] The electrochemical test adopts a t...

Embodiment 3

[0026] Change the thickness of the copper foil in Example 2 to a copper foil sheet of 0.5mm, wash it repeatedly with distilled water and deionized water, and put it in an oven to dry after ultrasonication. Prepare a KOH solution with a mass fraction of 5%, let it stand for 10 minutes, take the prepared solution in a beaker, place it in a constant temperature water bath, adjust the temperature to 30°C, put the cleaned and dried copper foil in the beaker, and let it stand After 6 days, the samples were removed, rinsed slowly with distilled water and again with deionized water, and dried. The dried three-dimensional copper oxide nanoflowers were observed under a scanning electron microscope to obtain a picture similar to Example 3. The three-dimensional copper oxide nanoflowers were evenly distributed on the electrode surface, the nanoflowers were closely packed, and the shape of a single nanoflower was clear. The diameter of a single nanoflower was At 10-20 μm.

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Abstract

The invention relates to a chip enzyme-free glucose sensor electrode based on three-dimensional copper oxide nanometer flowers as well as a preparation method and application thereof. In the invention, the nanometer flowers directly grow in situ on the surface of a copper foil; the nanometer flower-based chip enzyme-free glucose sensor electrode is composed of a copper foil substrate and a three-dimensional copper oxide nanometer flower array; and the three-dimensional copper oxide nanometer flowers with diameters of 10-20 microns exist in a crystal morphology and are uniformly and compactly distributed on the surface of the electrode. The preparation method comprises the steps of selecting a copper foil slice with a thickness of 0.2-0.5mm, putting the cleaned and dried copper foil into a KOH solution at a temperature about 30-40 DEG C for 3-9 days, after the reaction is completed, taking out a sample, repeatedly washing by utilizing distilled water and deionized water and drying at a room temperature. The three-dimensional copper oxide nanometer flower-based chip enzyme-free glucose sensor electrode can be applied to electronic equipment for continuously monitoring blood glucose concentration.

Description

technical field [0001] The invention relates to an enzyme-free glucose sensor electrode based on a three-dimensional copper oxide nanometer chip, a preparation method and an application. Background technique [0002] In recent decades, research on electrochemical biosensors with immobilized glucose oxidase has achieved certain results. Enzyme-based sensors have good selectivity and sensitivity in the monitoring process, and have made great contributions to the invasive and non-invasive detection of blood glucose in diabetic patients. However, for the diagnosis and treatment of diabetes, the most important thing is a repeatable, accurate, fast, selective and cheap blood glucose monitoring device in biological fluid. However, due to the characteristics of the enzyme itself, it is extremely easy to inactivate and denature during the immobilization process, so poor stability has become the biggest problem of enzyme-based sensors; secondly, the amount of immobilized enzyme canno...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327
Inventor 许鑫华方海东郭美卿
Owner TIANJIN UNIV
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