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Veterinary compound hydrochloric acid injection and preparation method thereof

A technology of oxytetracycline hydrochloride and injection, which is applied in the field of veterinary compound oxytetracycline hydrochloride injection and its preparation, can solve the problems of inaccurate curative effect of Eperythrozoon porcine, and achieve the simple and easy-to-operate preparation method and obvious effect Effect

Inactive Publication Date: 2012-06-27
XUCHANG TIANYUAN BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The injection is specially aimed at diseases of the respiratory system of livestock and poultry, and the curative effect on pig Eperythrozoon is not certain

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0038] The preparation method of the injection of the above-mentioned composition and content is as follows:

[0039] 1) Take 50% organic solvent, add diclofenac sodium and midazolium, stir to dissolve, as

[0040] No. solution spare,

[0041] 2) Take another newly prepared water for injection of the prescribed amount, add the prescribed amount of sodium formaldehyde sulfoxylate,

[0042] Stir to dissolve,

[0043] 3), then add the prescribed amount of ethanolamine, stir evenly,

[0044] 4) Add the prescribed amount of injection-grade oxytetracycline hydrochloride, stir to dissolve,

[0045] 5), then add the remaining organic solvent, stir to dissolve,

[0046] 6), then add the prescribed amount of magnesium chloride, stir to dissolve it, and then use it as The solution is ready for use,

[0047] 7), will solution and The solution is mixed and stirred evenly,

[0048] 8) Filtrate with a carbon rod filter, potting, and sterilize at 100°C for 30 minutes.

[0049] ...

Embodiment 1

[0052] Example 1: A kind of veterinary compound oxytetracycline hydrochloride injection, the compound oxytetracycline hydrochloride injection for veterinary every 100ml its raw material composition is as follows:

[0053] Active Ingredient: Injection Grade Oxytetracycline Hydrochloride 25g

[0054] Diclofenac Sodium 1.5g

[0055] Midazolium 0.1g

[0056] Excipient: sodium formaldehyde sulfoxylate 0.2g

[0057] Magnesium chloride 5g

[0058] Ethanolamine 5ml

[0059] Dimethylformamide 40ml

[0060] Polyethylene Glycol-400 20ml

[0061] Water for injection 20ml

[0062] The preparation steps of the injection of above-mentioned composition and content are as follows:

[0063] 1) Mix 40ml of dimethylformamide with 20ml of polyethylene glycol-400 evenly. -- liquid.

[0064] 2) Take 30ml Liquid, add the amount of diclofenac sodium and midazolium, stir to dissolve. --I

[0065] liquid (spare). ...

Embodiment 2

[0075] Example 2: A kind of veterinary compound oxytetracycline hydrochloride injection, the compound oxytetracycline hydrochloride injection for veterinary every 100ml its raw material composition is as follows:

[0076] Active ingredient: Injection grade oxytetracycline hydrochloride 10g

[0077] Diclofenac Sodium 5g

[0078] Midazolium 0.1g

[0079] Excipient: sodium formaldehyde sulfoxylate 0.2g

[0080] Magnesium chloride 5g

[0081] Ethanolamine 5ml

[0082] Dimethylformamide 40ml

[0083] Polyethylene Glycol-400 20ml

[0084] Water for injection 24ml

[0085] Its preparation method is the same as embodiment 1 according to the amount of the present embodiment.

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PUM

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Abstract

The invention relates to veterinary compound hydrochloric acid injection and a preparation method thereof. The veterinary compound hydrochloric acid injection consists of oxytetracycline dihydrate injection, imidocarb and diclofenac sodium; the veterinary compound hydrochloric acid injection per 100 ml comprises the required raw materials of: 10-25g of oxytetracycline dihydrate injection, 1.5-5g of diclofenac sodium, 0.1-0.2g of imidocarb, 0.2-0.6g of sodium formaldehyde sulphoxylate, 5-15g of magnesium chloride, 5-13 ml of ethanolamine and 60-81 ml of organic solvents, wherein the allowance is water for injection. The veterinary compound hydrochloric acid injection has remarkable effect when being used for treating acute respiratory infection caused by eperythrozoon suis, babesiosis and other blood protozoa diseases, porcine respiratory disease complex (PRDC) and swine influenza virus (SIV), airway inflammation induced by porcine reproductive and respiratory syndrome (PRRS), haemophilus parasuis, pasteurella, pleuropneumonia and mycoplasma diseases; and the preparation method is simple and easy to operate, and is suitable for batch production.

Description

technical field [0001] The invention relates to a veterinary compound oxytetracycline hydrochloride injection, in particular to a veterinary compound oxytetracycline hydrochloride injection composed of injection-grade oxytetracycline hydrochloride, midazolium and diclofenac sodium and a preparation method thereof. Background technique [0002] Since the first report of Eperythrozoon disease in India by Doyle in 1932, Eperythrozoon has subsequently been found worldwide from piglets to pregnant sows. In my country, after Xu Yaocheng et al. (1982) found Eperythrozoon porcine in the blood of erythrodermic pigs in southern Jiangsu for the first time, the disease has spread throughout the country. After the body is infected with Eperythrozoon, it not only leads to a decrease in productivity, but also reduces the output of milk and meat. What is more serious is that the immunity of pigs infected with Eperythrozoon is reduced, which opens a green channel for the invasion of other pa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4178A61K31/196A61K31/167A61K9/08A61P33/00A61P11/00A61P31/16A61P29/00A61P31/04
Inventor 罗振军蒋二强吴小萍江红格张永奎
Owner XUCHANG TIANYUAN BIOLOGICAL TECH CO LTD
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