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Method for preparing heart and spleen tonifying capsules

A technology for nourishing the heart and strengthening the spleen and capsules, which is applied in the directions of capsule delivery, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problem of inability to reduce the number of capsules, inability to effectively improve hygroscopicity, and uneven particle size, etc. problems, to achieve the effect of increasing the capsule filling capacity, less application of auxiliary materials, and uniform particle size

Inactive Publication Date: 2011-08-10
GUANGXI JIANFENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, due to the problems of granulation technology, the size of the granules produced is uneven and the appearance is not round.
Moreover, the particle itself has a small density and a large specific surface area, so that its hygroscopicity cannot be effectively improved, and it is easy to absorb moisture and bond
In view of the more or less problems existing in the existing granulation technology, the prepared granules cannot achieve the purpose of reducing the number of capsules or shrinking the size of the capsule shell. method

Method used

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  • Method for preparing heart and spleen tonifying capsules
  • Method for preparing heart and spleen tonifying capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Prescription (parts by weight):

[0026] Based on the patent CN200610034147.8 invented by the inventor, 5.4-32.6 parts of Astragalus, 5.4-16.3 parts of Ganoderma lucidum, 5.4-16.3 parts of Suanzaoren, 5.4-32.6 parts of Huoling, 5.4-32.6 parts of Jujube, and 0.1-16.3 parts of Licorice 0.5 to 26.0 parts of pig blood.

[0027] (2) Preparation method:

[0028] After mixing astragalus, ganoderma lucidum, jujube seed, huoling, jujube, and licorice, use alcohol extraction method to add 3 to 6 times the weight of alcohol solvent and boil once, control the temperature at 45°C for 1.5 hours, filter, and remove the residue to obtain The extract is distilled under reduced pressure to reclaim the alcohol solvent, dehydrated under reduced pressure and concentrated into a thick clear paste with a relative density of 1.10 for later use; the dregs are prepared by semi-bionic extraction with 5 times the weight of hydrochloric acid or acetic acid and water to form an acidic aqueous s...

Embodiment 2

[0031] (1) Prescription (parts by weight):

[0032] Based on the patent CN200610034147.8 invented by the inventor, 30 parts of astragalus, 13 parts of Ganoderma lucidum, 10 parts of Suanzaoren, 26 parts of Huoling, 20 parts of Dazao, 13 parts of licorice and 20 parts of pig blood.

[0033] (2) Preparation method:

[0034] After mixing astragalus, ganoderma lucidum, wild jujube seed, huling, jujube, and licorice, cook once with alcohol solvent and alcohol with 4 times the weight of alcohol, control the temperature at 55°C for 1 hour, filter, and remove the residue to obtain the extract , the alcohol solvent is recovered by distillation under reduced pressure, dehydrated under reduced pressure and concentrated into a thick clear paste with a relative density of 1.10 for subsequent use; the dregs are decocted with 3 times the weight of hydrochloric acid or acetic acid and water to form an acidic aqueous solution with a pH value of 5 by using a semi-bionic extraction method , con...

example 1

[0038] Cheng XX, female, 52 years old, was admitted to the hospital on August 9, 2010 due to "poor breathing". Spots, thin white fur, deep thready pulse. Diagnosed as qi deficiency and blood stasis type of chest obstruction. After taking the Chinese medicine preparation treatment of benefiting the heart and invigorating the spleen of the present invention, take 3 times every day, each 2 capsules. After taking it for 12 days, chest tightness, shortness of breath, palpitation, fatigue and dizziness began to alleviate, and after the sixth week, the symptoms disappeared.

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Abstract

The invention discloses a method for preparing heart and spleen tonifying capsules. In the method, active ingredients of crude medicaments are extracted by an alcohol extraction method and a semi-bionic extraction method, impurities are removed by alcohol precipitation, and granular bulk density is increased by the compact granulation technology. In the semi-bionic extraction method, acid solution of which the pH value is between 2 and 5 is prepared from hydrochloric acid or acetic acid and water, and semi-bionic extraction is performed at the temperature of between 40 and 95 DEG C for 0.5 to 1 hour; in the alcohol extraction method, alcohol boiling is performed at the temperature of between 35 and 55 DEG C for 1 to 1.5 hours; and the process for removing the impurities by the alcohol precipitation comprises the following steps of: adding ethanol serving as an organic solvent until the ethanol content is 50 to 70 percent, and stirring and standing for 8 to 12 hours. By the method, the bulk density of medicinal granules is high, so that the administration number of the capsules is reduced or the types of capsule shells are reduced; and the filled capacity of the capsules is improved while single administration dose is not changed, the moisture absorption of the medicaments is improved effectively, more moisture is prevented from being adsorbed, and the medicaments hardly absorb moisture so as not to be bonded. Clinical verification results prove that the products have the total effective rate of over 93.3 percent.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a traditional Chinese medicine preparation for nourishing the heart and invigorating the spleen, in particular to a preparation method of a capsule for strengthening the heart and strengthening the spleen. Background technique [0002] A "preparation method of Chinese patent medicine for benefiting the heart and invigorating the spleen" is a patent invented by the inventor, the patent number is CN200610034147.8. As a raw material, by weight, 5.4-32.6 parts of astragalus, 5.4-16.3 parts of ganoderma lucidum, 5.4-16.3 parts of jujube seed, 5.4-32.6 parts of Huoling, 5.4-32.6 parts of jujube, 0.1-16.3 parts of licorice and 0.5-16.3 parts of pig blood 26.0 servings, first mix and decoct astragalus, ganoderma lucidum, jujube seed, huoling, jujube, and licorice for 1 to 3 hours. The number of times of mixing and decocting is at least 2 times. Combine th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61P9/06A61P1/14A61P25/20A61K36/725A61K35/14
Inventor 黄大权
Owner GUANGXI JIANFENG PHARMA
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