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Method for reducing ignition residues in ginkgo leaf extract

A burning residue and extract technology, which is applied in the field of medicinally active plant components, can solve the problems of reduced yield and complicated process, and achieve the effects of strong production operability, simple process flow, and stable product quality

Inactive Publication Date: 2011-08-10
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a method for reducing the amount of burning residue in the Ginkgo biloba extract, which is a convenient method for industrial production, while ensuring that other active components in the Ginkgo biloba extract are not lost, so as to solve the problem of the existing production process. The process of using alcohol precipitation to reduce the residue on ignition is complex and has the disadvantages of reduced yield

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The first step is to take 500kg of ginkgo biloba extract, add 4t of water to boil, extract for 2 hours, and cool the extract to room temperature;

[0016] In the second step, the extract is filtered with diatomaceous earth, and the filtrate is vacuum-concentrated to 1 / 3 volume at a vacuum degree of 0.08MPa and a temperature of 70°C for later use;

[0017] In the third step, the filtrate is put on a macroporous resin column, and the model is DM-130 resin for dynamic adsorption separation, washed with deionized water to remove salt and impurities, and at the same time use a conductivity meter to monitor the conductivity to drop to 15; then use 3 times the column volume Mass fraction is 65% ethanol elution;

[0018] In the fourth step, the eluate is vacuum concentrated to dryness at a vacuum degree of 0.08 MPa to obtain a residue on ignition of 0.19% ginkgo biloba extract, and the product is a brown extract.

Embodiment 2

[0020] In the first step, take 200 kg of ginkgo biloba extract, add 1.6 t of ethanol with a mass fraction of 60%, and extract at a constant temperature of 60 ° C for 2 hours, concentrate the extract in vacuo to recover ethanol, and cool to room temperature;

[0021] In the second step, the extract is filtered with diatomaceous earth, and the filtrate is vacuum-concentrated to 1 / 3 volume under a vacuum degree of 0.08 MPa for later use;

[0022] The third step is to put the filtrate on a macroporous resin column, use D-101 resin for dynamic adsorption separation, wash with deionized water to remove salt and impurities, and use a conductivity meter to monitor the conductivity until it drops to 10; then use 3 times the column volume The mass fraction is 65% ethanol elution;

[0023] In the fourth step, the eluate is vacuum concentrated to dryness at a vacuum degree of 0.08 MPa to obtain a residue on ignition of 0.15% ginkgo biloba extract, and the product is a brown extract.

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Abstract

The invention discloses a method for reducing ignition residues in a ginkgo leaf extract, which comprises the following steps of: performing water extraction or alcohol extraction on ginkgo leaf serving as a raw material to obtain an extract, concentrating under vacuum, filtering by using kieselguhr, and allowing filter liquor to pass through a macroporous resin column for separating; after sample liquor passes through the column, washing impurities by using deionized water until salt substances are washed completely; eluting by using ethanol, and collecting eluent; and concentrating the eluent until the eluent is dried, and crushing to obtain the ginkgo leaf extract with low content of ignition residues. In the method, the ignition residues are reduced to be lower than 0.2 percent under the condition that other active ingredients in the ginkgo leaf extract is not lost. The method has the advantages of simpleness, stable quality of products, high operability of production, and no influence on the active ingredients and yield of the products and the like, and can be used for the industrial production of the ginkgo leaf extract.

Description

technical field [0001] The present invention relates to medicinally active plant components, in particular to the burnt residue of Ginkgo biloba extract. Background technique [0002] Ginkgo biloba extract is a plant extract developed in my country since the 1970s. Currently, the sales volume of plant extracts accounts for the top three among various plant extracts. The standard technology of Ginkgo biloba extract in foreign countries is mainly based on the standards and operating specifications of Ginkgo biloba extract for medicinal use issued by the Fifth Bureau of the German Drug Administration (Kommisson E) in September 1994, which is the internationally recognized standard for Ginkgo biloba extract. In the 2000 edition of the Chinese Pharmacopoeia, my country put forward the requirements for the burning residue of ginkgo leaf extract to be less than 0.8%. The 2005 and 2010 editions have not changed. However, the international ginkgo leaf extract requires less than 0.3% ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K127/00
Inventor 何珺杨佳年何照范康冀川
Owner GUIZHOU UNIV
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