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Cortex phellodendri polysaccharide extract and preparation method and medical application thereof

Phellodendron phellodendron extract, immunosuppressive technology, applied in medical formulas, medical preparations containing active ingredients, diseases, etc.

Active Publication Date: 2013-09-11
匡海学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, Phellodendron Phellodendri polysaccharides exert immunosuppressive activity for the treatment of such diseases has not been reported

Method used

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  • Cortex phellodendri polysaccharide extract and preparation method and medical application thereof
  • Cortex phellodendri polysaccharide extract and preparation method and medical application thereof
  • Cortex phellodendri polysaccharide extract and preparation method and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take about 500g of Phellodendron Phellodendron powder (dried at 60°C for 8h) dried to constant weight, reflux extraction with 95% ethanol for 3 times, each time for 3h, filter with linen cloth, put the filter residue in a ventilated place to dry naturally, add distilled water to the residue 6 times the amount, reflux extraction 3 times, 3 hours each time, suction filtration with linen cloth, combined filtrates, recovering the solvent under reduced pressure to 0.5 times the volume, adjusting the alcohol content to 80% with 95% ethanol, standing overnight, 2000rpm Centrifuge for 1 minute, the precipitate is washed successively with 3 times the amount of absolute ethanol and acetone, dissolved in distilled water, and the total pigment and protein are removed by weak acid and weak base type anion and cation exchange resins to obtain the crude extract of Cortex Phellodendri. Take the crude extract and dissolve it in water, put the supernatant into a dialysis bag and dialyze f...

Embodiment 2

[0017] Take about 500g of Phellodendron Phellodendri powder (dried at 60°C for 8h) dried to constant weight, extract twice with 80% ethanol under reflux, each time for 3h, filter with linen cloth, put the filter residue in a ventilated place to dry naturally, add distilled water to the residue 10 times the volume, reflux extraction twice, 3 hours each time, suction filtration with linen cloth, combined filtrates, recovering the solvent under reduced pressure to 1.0 times the volume, adjusting the alcohol content to 85% with 100% ethanol, standing overnight, 2000rpm Centrifuge for 10 minutes, wash the precipitate with 4 times the amount of absolute ethanol and acetone in turn, dissolve in distilled water, go through weak acid and weak base type anion and cation exchange resins to remove pigment and freeze-dry the protein to obtain the extract. With DNS colorimetry, 722-type visible spectrophotometer at 480nm, measure the polysaccharide content of Phellodendron Phellodendri, whic...

Embodiment 3

[0018] Embodiment 3 is made transfusion

[0019] Take an appropriate amount of Phellodendron Phellodendri extract prepared in Example 1, add an appropriate amount of solubilizer, grind, then add a small amount of water for injection to dilute, mix well, then add an appropriate amount of sodium chloride, dissolve and then add water for injection to the specified amount, filter, Potting, sterilization, that is.

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PUM

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Abstract

The invention relates to cortex phellodendri polysaccharide extract and a preparation method and medical application thereof. The content of cortex phellodendri polysaccharide in the extract is counted by glucose, and the content of the polysaccharide accounts for above 65% of the cortex phellodendri extract in percentage by weight. Found by a large number of pharmacological experiments, the cortex phellodendri general polysaccharide extract has notable immunosuppressive activity, can be prepared into immunosuppressive medicaments or used as a medicinal material for preparing other immunosuppressive medicaments, and can be used for treating various immunoreaction-related diseases, including nephritis, pharyngitis, pneumonitis, upper respiratory tract infection, hepatitis, enteritis, gynecologic inflammation, rheumatoid arthritis, diabetes and other immune-related diseases.

Description

technical field [0001] The present invention relates to an extract of effective parts of traditional Chinese medicine, in particular to an extract of Phellodendron Phellodendron with immunosuppressive activity and a preparation method thereof. The medicinal use of diseases such as nephritis, pharyngitis, pneumonia, upper respiratory tract infection, hepatitis, enteritis, gynecological inflammation, rheumatoid arthritis, diabetes and other immune-related diseases belongs to the field of extracts from effective parts of traditional Chinese medicine. Background technique [0002] Phellodendron Chinense Schneid. and Phellodendron Chinense Schneid. and Phellodendron Chinense Schneid. are the dry bark of Phellodendron Chinense Schneid. (P.Amurense Rupr.). This product was first recorded in "Shen Nong's Materia Medica", formerly known as "Bo Shu", listed as the top grade. It is an important and commonly used Chinese herbal medicine in traditional Chinese medicine to "maintain heat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/756A61P37/06A61P1/00A61P1/16A61P3/10A61P11/00A61P11/04A61P13/12A61P15/00A61P19/02A61P19/04A61P29/00A61K129/00
Inventor 匡海学王秋红杨炳友夏永刚焦文娟
Owner 匡海学
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