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Yellow dog penis extractive with resistance to ovarian function progeria as well as preparation method and applications thereof

A technology of ovarian function and yellow dog kidney, applied in the field of animal medicine, can solve the problems of low extraction rate, disappearance, and reduced activity of active ingredients, and achieve the effects of high extraction effect, good drug effect, and increasing estradiol content.

Inactive Publication Date: 2011-08-03
JIANGSU PROVINCIAL HOSPITAL OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current yellow dog kidney is used directly as a medicinal flavor, which has a strong fishy smell and contains more non-medicinal ingredients, which brings more inconvenience to taking, and the existing extraction methods of yellow dog kidney are mostly water extraction or Alcohol extraction, the extraction rate of active ingredients in the existing extraction method is low, and the extract contains many other impurities, and the active ingredients in the yellow dog kidney are easily destroyed under high temperature conditions, resulting in reduced activity or even disappearance

Method used

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  • Yellow dog penis extractive with resistance to ovarian function progeria as well as preparation method and applications thereof
  • Yellow dog penis extractive with resistance to ovarian function progeria as well as preparation method and applications thereof
  • Yellow dog penis extractive with resistance to ovarian function progeria as well as preparation method and applications thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0043] A yellow dog kidney extract with anti-ovarian premature aging, which is prepared by the following method:

[0044] Take the yellow dog kidney decoction pieces, soak them in 95% ethanol for 2 hours, and then use supercritical CO 2 The fluid is extracted to obtain an extract, and then vacuum-dried to obtain a yellow dog kidney extract. The main components of the extract are fatty acids and sex hormone components. of which supercritical CO 2 The fluid extraction conditions are: the extraction pressure is 25MPa, and the extraction temperature is 65°C; the pressure of the separation tank I is 5MPa, and the temperature is 40°C; the pressure of the separation tank II is 5MPa, and the temperature is 35°C; the entrainer is 95% ethanol, The ratio of the volume of the entrainer 95% ethanol in milliliters to the weight in grams of the yellow dog kidney decoction pieces is 1 (ml / g); the extraction time is 2 hours.

Embodiment 2

[0046] A yellow dog kidney extract with anti-ovarian premature aging, which is prepared by the following method:

[0047] Take the yellow dog kidney decoction pieces, soak them in 90% ethanol for 4 hours, and then use supercritical CO 2 The fluid is extracted to obtain an extract, and then vacuum-dried to obtain a yellow dog kidney extract. The main components of the extract are fatty acids and sex hormone components. of which supercritical CO 2 The fluid extraction conditions are: the extraction pressure is 35MPa, and the extraction temperature is 55°C; the pressure of the separation tank I is 4MPa, and the temperature is 40°C; the pressure of the separation tank II is 4MPa, and the temperature is 30°C; the entrainer is 95% ethanol, The volume ratio of the entraining agent 95% ethanol in milliliters to the weight in grams of the yellow dog kidney decoction pieces is 2 (ml / g); the extraction time is 3 hours.

Embodiment 3

[0049] A yellow dog kidney extract with anti-ovarian premature aging, which is prepared by the following method:

[0050] Take the yellow dog kidney decoction pieces, soak them in 90% ethanol for 3 hours, and then use supercritical CO 2 The fluid is extracted to obtain an extract, and then vacuum-dried to obtain a yellow dog kidney extract. The main components of the extract are fatty acids and sex hormone components. of which supercritical CO 2 The fluid extraction conditions are: the extraction pressure is 30MPa, and the extraction temperature is 60°C; the pressure of the separation tank I is 5MPa, and the temperature is 35°C; the pressure of the separation tank II is 3MPa, and the temperature is 35°C; the entrainer is 95% ethanol, The volume ratio of the entraining agent 95% ethanol in milliliters to the weight in grams of the yellow dog kidney decoction pieces is 3 (ml / g); the extraction time is 2 hours.

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Abstract

The invention discloses a yellow dog penis extractive with resistance to ovarian function progeria as well as a preparation method and applications thereof. The extractive is prepared by using the preparation method comprising the following steps: taking yellow dog penis slices firstly, soaking the yellow dog penis slices in ethanol with the concentration of 90-95 percent for 2-4h; then, extracting with supercritical CO2 fluid to obtain an extract; and drying in vacuum to obtain a yellow dog penis extractive, wherein the supercritical CO2 fluid is prepared under the extraction conditions: theextraction pressure is 25MPa, the extraction temperature is 65 DEG C, a separation kettle I has the pressure of 5 MPa and the temperature of 40 DEG C; a separation kettle II has the pressure of 5 MPaand the temperature of 35 DEG C; the entrainer is 95% ethanol; and the extraction time is 2h. The yellow dog penis extractive provided by the invention has high active ingredient content and less inactive large-polarity compounds and determines the optimal process with highest active ingredient extraction efficiency by inspecting the extraction pressure, the extraction temperature and the extraction time of the supercritical CO2, the entrainer and the dosage thereof. Shown by experimental results and compared with a traditional aqueous extract or an alcohol extract, the supercritical CO2 extract has better resistance to the ovarian function progeria.

Description

technical field [0001] The invention relates to an animal medicine, in particular to a yellow dog kidney extract capable of resisting premature ovarian failure and its preparation method and application. Background technique [0002] The yellow dog kidney is the dried penis and testicles of the canis male dog Canis familiaris L., also known as dog whip and wide dog kidney. It is warm in nature, sweet and salty in taste, and belongs to the kidney meridian. It has the effects of strengthening yang, nourishing kidney, nourishing essence and marrow. It is mainly used to treat male impotence caused by kidney deficiency and yang failure, cold and painful scrotum, chills and cold limbs, soreness and weakness of waist and knees, etc. Studies have reported that the main medicinal components of Yellow Dog Kidney are fat and sex hormones. The current yellow dog kidney is used directly as a medicinal flavor, which has a strong fishy smell and contains more non-medicinal ingredients, w...

Claims

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Application Information

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IPC IPC(8): A61K35/48A61P15/08
Inventor 刘志辉陈武朱萱萱周琴妹周洪亮翁燕
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
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