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Spermicidal contraceptive gel composition and preparation method thereof

A technology of gel composition and mixture, which is applied in the direction of drug combination, active ingredients of artificially synthesized polymer materials, diseases, etc., and can solve the problems of spermicide and its contraceptive application, interference with estrogen secretion system, vaginal insufficiency, etc. Expensive will cause problems such as bleeding, and achieve the effects of easy procurement, broad application prospects, and no toxic and side effects

Inactive Publication Date: 2011-07-27
SHANGHAI OPAI BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Condoms are the most commonly used contraceptive tools at present. The main principle is to use physical forms to prevent sperm from passing through the membrane and enter the female uterus, so as to achieve the purpose of contraception. However, some people may have safety problems such as allergic reactions, rupture, and slippage during sexual intercourse. occur; there are certain deficiencies in use
The main principle of oral contraceptives is to interfere with the female estrogen secretion system after being orally absorbed by women, so that women do not ovulate, so as to achieve the purpose of contraception. The disadvantage is that it will cause nausea, vomiting, and even bleeding in women if the vagina is not expensive.
But the invention does not mention spermicide and its use in contraception

Method used

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  • Spermicidal contraceptive gel composition and preparation method thereof
  • Spermicidal contraceptive gel composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Spermicidal and Contraceptive Gel Composition

[0025] In one embodiment of the present invention, the main components of the spermicidal contraceptive gel composition include: didecyldimethylammonium chloride, tetradecyldimethylbenzylammonium chloride, octoxynol, and Medically acceptable excipients. There are 5 kinds of proportioning combinations in the present embodiment, and each composition, drug specification and addition of every kind of proportioning combination are as follows:

[0026] .

Embodiment 2

[0027] Example 2 Preparation method of spermicidal contraceptive gel composition

[0028] The specific operation steps are as follows:

[0029] (1) Put cetyl dimethyl ammonium oxide measured in Example 1 and a small amount of demineralized water into a glass container, stir and dissolve to form mixture A;

[0030] (2) The didecyldimethylammonium chloride and tetradecyldimethylbenzylammonium chloride measured in Example 1 were respectively dissolved in part of the demineralized water under constant stirring to form a mixture B;

[0031] (3) Mix mixture A and mixture B together, add a small amount of demineralized water and stir until uniform, forming mixture C;

[0032] (4) Add mixture C to the measured octoxynol and aloe in Example 1, and fully stir until uniform to form mixture D;

[0033] (5) Add sodium hydroxide solution to the mixture D to adjust the pH value between 5.2-6.7. Formation of mixture E;

[0034] (6) Add the mixture E to the measured methylcellulose in Exam...

Embodiment 3

[0035] Example 3 Spermicidal Test of Spermicidal Contraceptive Gel Composition

[0036] experiment material:

[0037] Trinocular biological microscope XSP-BM19A (produced by Shanghai Optical Instrument Factory), with a total magnification of 40X-1600X, is used to observe sperm activity. Spermicidal contraceptive gel (gained from Example 2). Nonoxynol gel, active ingredient content 4% (Lelemi brand produced by China Pharmaceutical University Pharmaceutical Co., Ltd.), production date: February 1, 2008, expiry date: Batch: 080201, provided by the manufacturer. Semen samples, the semen samples used in the experiment were selected from 32 healthy males aged 25-30, abstaining from sex for 5-7 days, masturbating and taking the semen in a clean and sterilized 50ml small beaker. The sperm met the normal standard recommended by WHO (see: WHO, Human Semen and Sperm-Cervical Mucus Interaction Laboratory Test Manual (M), Fourth Edition, Beijing: People's Health Publishing House, 2001, 5...

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Abstract

The invention discloses a spermicidal contraceptive gel composition and a preparation method thereof. The spermicidal contraceptive gel composition mainly comprises 0.01-5% of didecyl dimethyl ammonium chloride, 0.01-5% of tetradecyl dimethyl benzyl ammonium chloride, 0.01-12% of octoxinol and medically acceptable auxiliary materials. The spermicidal contraceptive gel composition disclosed by the invention has fast spermicidal speed, high efficiency, convenience in use, safety, cheapness, efficacies of lubricating, diminishing inflammation and sterilizing, and no toxic side effects.

Description

technical field [0001] The invention provides a spermicidal and contraceptive gel composition. The spermicidal and contraceptive gel composition is composed of multiple drugs, has fast spermicidal speed, high efficiency, is easy to use, is safe and cheap, has lubricating, anti-inflammatory and bactericidal effects, and has no toxic and side effects. The invention also provides a preparation method of the spermicidal and contraceptive gel composition. Background technique [0002] Our country has a large population, and family planning is the basic national policy of our country. It is of great significance to develop family planning products that are safe, effective, convenient to use, have no side effects on the human body, have market promotion value, and can be mass-produced. [0003] In addition to the country’s partial infertility surgery for married couples, there are many other unmarried or married youths who currently use three types of contraceptive methods: rubber...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/77A61K31/14A61K9/06A61P15/18A61P31/04A61P29/00
Inventor 李鸿文
Owner SHANGHAI OPAI BIOLOGICAL TECH
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