Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Film preparation containing loperamide hydrochloride

A technology for loperamide hydrochloride and film preparations, applied in the field of film preparations containing loperamide hydrochloride, can solve the problems of masking hints or teachings, no bitter taste of loperamide hydrochloride, etc., and achieves excellent portability and ease of use. The effect of unpleasant sensations

Active Publication Date: 2011-07-20
KYUKYU PHARMA
View PDF12 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a dosage form, only a tablet is disclosed substantially, and there is no hint or teaching about the bitterness masking of a film preparation containing loperamide hydrochloride

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Film preparation containing loperamide hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Dissolve 50g of powdered reduced maltose syrup and 40g of polyethylene glycol 400 in 500g of water. Next, a dispersion liquid obtained by dispersing 50 g of titanium oxide in 750 g of absolute ethanol was added to this liquid. Then, 360 g of hypromellose was added to the obtained liquid, and the coating layer preparation liquid was obtained.

[0063]Dissolve 27g of loperamide hydrochloride, 64.8g of polyethylene glycol 400, 256.5g of powdered reduced maltose syrup, 54g of sodium saccharin and 27g of 1-menthol in a mixed solution of 810g of water and 810g of absolute ethanol. 380.7 g of hydroxypropyl cellulose and 1.35 g of flavoring agent were added to the liquid to obtain a drug-containing intermediate layer preparation liquid.

[0064] After coating the coating layer preparation solution evenly on the PET film, dry it with warm air to form a 2 The mass of the area is 5 mg of the coating layer. After uniformly coating the intermediate layer preparation solution cont...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Disclosed is a film preparation which is characterized by comprising: a drug-containing intermediate layer comprising loperamide hydrochloride, a terpene and a film-forming agent; and coating layers each comprising a film-forming agent and a plasticizer (containing no terpene) and laminated on both surfaces of the drug-containing intermediate layer. In the film preparation, the bitterness derived from loperamide hydrochloride is masked. Therefore, unpleasant sensation produced upon the intake of the film preparation can be reduced. Further, the film preparation can be dissolved rapidly only with a fluid in an oral cavity (i.e., has a rapidly dissolving property). Therefore, the film preparation is fast-acting and has superior portability.

Description

technical field [0001] The present invention relates to a film preparation in which the bitter taste of loperamide hydrochloride is masked, a method for producing the same, and a method for masking the bitter taste of a film preparation containing loperamide hydrochloride. Background technique [0002] Loperamide hydrochloride is widely used as an antidiarrheal drug. As a preparation containing loperamide hydrochloride, a preparation that can be taken even when acute diarrhea occurs in a place where drinking water is difficult, such as on the way to work or during a meeting, has been sold. However, since loperamide hydrochloride has a very strong bitter taste, there is a problem in the feeling of taking it. [0003] As a method of masking such a bitter taste, for example, Patent Documents 1 to 5 propose adding a sweetener, a surfactant, and the like to a medicine having a bitter taste. However, none of these known technologies suggests or teaches about the masking of bitte...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/451A61K9/70A61K47/10A61K47/38A61P1/12
CPCA61K9/0056A61K9/7007A61K31/045A61K31/451A61P1/12Y10T156/10A61K47/10A61K47/38
Inventor 粟村努西川久信稻木敏男
Owner KYUKYU PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com