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Artificially processed bear bile powder and preparation method thereof

A technology of bear bile powder and artificial technology, which is applied in the direction of medical formula, medical preparations containing active ingredients, digestive system, etc., can solve the problems of easy moisture absorption, complicated preparation process, expensive bear bile powder, etc., to facilitate storage and transportation And processing, preparation method is simple, the effect of pure appearance color

Active Publication Date: 2013-03-27
福建归真堂药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although artificial bear bile powder contains some main components in natural bear bile, its components are single and the preparation process is complicated, so it is not suitable for large-scale industrial production
[0006] At present, the price of bear bile powder on the market is expensive, easy to absorb moisture, and the content of tauroursodeoxycholic acid in bear bile powder is relatively low, which greatly limits its application in medicine and health care.

Method used

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  • Artificially processed bear bile powder and preparation method thereof
  • Artificially processed bear bile powder and preparation method thereof
  • Artificially processed bear bile powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0175] After the adult black bear bred in the Sichuan Provincial Musk Deer Research Institute completed cleaning, hair removal, and disinfection, the subcutaneous tissue was cut 1 cm below the xiphoid process on the abdominal midline, the muscles were bluntly separated, and the sarcolemma and peritoneum were cut. , pull out the gallbladder slowly, cut a 1cm wound in the gallbladder, and form a fistula with the muscle tissue, and tie it tightly with sutures; then fix the gallbladder and gallbladder skin; suture the peritoneum, fat, fascia, muscle and skin respectively; then Clean and disinfect the surgical port. Two hours after waking up from the operation, the bears were given honey water or sugar water and egg water; within one week after the operation, the bears were given intramuscular injection or oral antibiotics to prevent wound infection, and a reasonable amount of nutritional feed was fed quantitatively. After recovery, the fistula was slightly squeezed to collect bile...

Embodiment 2

[0177] Adult black bears bred in Heibao Pharmaceutical Co., Ltd. of Heilongjiang Province were cleaned, depilated, and disinfected, and the subcutaneous tissue was cut 5 cm below the xiphoid process on the midline of the abdomen, and the muscles were bluntly separated. Membrane and peritoneum, slowly pull out the gallbladder, cut a 2cm wound in the gallbladder, and form a fistula with the muscle tissue, tie it properly with sutures; then fix the gallbladder and gallbladder skin; suture the peritoneum, fat, fascia, muscle and skin; then clean and disinfect the surgical port. Three hours after waking up from the operation, the bears were given honey water or sugar water and egg water; within one week after the operation, the bears were given intramuscular injection or oral antibiotics to prevent wound infection, and attention was paid to quantitatively feeding a reasonable mix of nutritional feed. After healed, the fistula was slightly squeezed to collect bile, and the bear bile...

Embodiment 3

[0179]Adult black bears bred in Guizhentang Pharmaceutical Co., Ltd., Fujian Province were cleaned, depilated, and sterilized. The subcutaneous tissue was cut 10 cm below the xiphoid process on the midline of the abdomen, and the muscles were bluntly separated. Membrane and peritoneum, the gallbladder is slowly pulled out, a 3cm wound is cut in the gallbladder, and a fistula is formed with the muscle tissue, which is properly tied with sutures; then the gallbladder and gallbladder skin are fixed; the peritoneum, fat, fascia, muscle and skin; then clean and disinfect the surgical port. Four hours after waking up from the operation, the bears were given honey water or sugar water and egg water; within one week after the operation, the bears were given intramuscular injection or oral antibiotics to prevent wound infection, and attention was paid to quantitatively feeding a reasonable mix of nutritional feed. After recovery, the fistula was slightly squeezed to collect bile, and t...

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Abstract

The invention discloses a preparation method of bear bile, which comprises the following steps: incising a wound on the gall bladder of a bear, forming a fistula with muscular tissues and binding up; and extruding a fistula orifice after healing so as to collect the bile. The method can be used for non-continuous, timing, quantitative and long-term collection, and can avoid affecting the utilization of the bile of the bear. The invention discloses high-quality bear bile powder and the preparation method thereof. The bear bile powder shows bright yellow fluorescence under a 365nm ultraviolet lamp and has three chromatographic peaks under 198nm. The preparation method of the powder comprises the steps of standing the bile, separating and drying the powder, and then crushing and screening the powder so as to get the bear bile powder. The prepared bear bile powder is pure in color and luster of appearance, high in the content of tauroursodeoxycholic acid, does not absorb moisture and is convenient to store, transport and process.

Description

technical field [0001] The invention relates to a method for extracting bile from animals, a method for producing bile powder and the bile powder, especially a method for extracting bile from the body of a bear, a method for producing bear bile powder and high-quality bear bile powder. Background technique [0002] Bear bile is the dry bile in the gallbladder of bears such as black bear Selenarctos thibetanus (G. Cuvier), Northeast brown bear Ursus arctos lasiotus Gray or brown bear Ursus arctos L. In China, it is mainly produced in Yunnan, Heilongjiang, and Jilin. In addition, it is also produced in Guizhou, Sichuan, Qinghai, Tibet, Xinjiang, Gansu, Hubei, Hunan, Shaanxi, Fujian and other places. The main ingredient in bear bile is alkali metal salts of bile acids, in addition, it also contains cholesterol and bile pigment. About 20% of tauroursodeoxycholic acid can be obtained from black bear bile. Bear bile also contains a small amount of chenodeoxycholic acid and chol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/413A61P1/16A61P27/02A61P29/00A61P31/12A61P35/00
Inventor 陈志鸿
Owner 福建归真堂药业股份有限公司
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