Carbon nanotube/chitosan/magnetic ferrite nanoparticle composite material, and preparation method and application thereof

A carbon nanotube and nanoparticle technology, which is applied in the field of nanocomposite materials to achieve the effects of good biocompatibility, integrity protection, and easy availability of raw materials

Inactive Publication Date: 2011-05-25
SHANGHAI NORMAL UNIVERSITY
View PDF1 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on the preparation of magnetic resonance contrast agents by modifying magnetic nanoparticles on carbon nanotubes.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Carbon nanotube/chitosan/magnetic ferrite nanoparticle composite material, and preparation method and application thereof
  • Carbon nanotube/chitosan/magnetic ferrite nanoparticle composite material, and preparation method and application thereof
  • Carbon nanotube/chitosan/magnetic ferrite nanoparticle composite material, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) 30mg chitosan is dissolved in the dilute acetic acid (2wt%) solution of 30mL;

[0035] (2) Add 30 mg of multi-walled carbon nanotubes (with a diameter of 10-100 nm and a length of 0.-15 μm) into the above solution, and ultrasonically disperse for 1 h;

[0036] (3) Slowly add 12 wt% dilute ammonia water to the solution obtained in (2) to pH=7 of the solution; then add 20 mL of a solution of 0.15 g / ml glutaraldehyde dropwise, and magnetically stir for 24 hours at room temperature, then centrifuge, Wash 5 times with distilled water, centrifuge at 12000rpm for 10min to get the precipitate, and obtain the treated carbon nanotubes;

[0037] (4) Disperse the above-mentioned treated carbon nanotubes in 50mL distilled water, super-disperse for 1h, and add 0.3mmol FeCl to it 3 ·6H 2 O and 0.15 mmol FeCl 2 4H 2 O, stirred for 30min to make Fe 3+ and Fe 2+ Fully coordinate with the O atoms in chitosan and modify the carbon nanotubes;

[0038](5) Add 1mol / L NaOH solution ...

Embodiment 2

[0043] (1) 30mg chitosan is dissolved in the dilute acetic acid (2wt%) solution of 30mL;

[0044] (2) Add 30 mg of multi-walled carbon nanotubes (with a diameter of 10-100 nm and a length of 0.-15 μm) into the above solution, and ultrasonically disperse for 1 h;

[0045] (3) Slowly add dilute ammonia water to the solution obtained in (2) until the pH of the solution is about 7, then add 20 mL of 15% glutaraldehyde solution dropwise, and after magnetic stirring at room temperature for 24 hours, centrifuge and wash with distilled water Wash 5 times, centrifuge at 12000rpm for 10min to get the precipitate, and obtain the treated carbon nanotubes;

[0046] (4) Disperse the carbon nanotubes obtained above in 50mL distilled water, ultrasonically disperse for 1h, and add 0.3mmol FeCl to it 3 ·6H 2 O and 0.15 mmol of CoCl 2 ·6H 2 O, stirred for 30min to make Fe 3+ and Co 2+ Fully coordinate with the O atoms in chitosan and modify the carbon nanotubes;

[0047] (5) Add 1mol / L Na...

Embodiment 3

[0052] Dilute acetic acid concentration is 5wt% in the step (1), and volume is 20ml, and the consumption of chitosan is 40mg;

[0053] The consumption of multi-walled carbon nanotubes in step (2) is 25mg;

[0054] Add 0.25g / ml glutaraldehyde solution 24ml in the step (3);

[0055] Add 0.3mmol FeCl in step (4) 3 ·6H 2 O and 0.15 mmol of CoCl 2 ·6H 2 O;

[0056] In step (5), at 95 ℃ of reaction 5h, all the other are with embodiment 1, obtain carbon nanotube / chitosan / magnetic ferrite nano particle composite material (with MWCNTs / CS / Fe 3 o 4 nanoparticle composites). The detection effect is the same as in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Lengthaaaaaaaaaa
The average particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention discloses a carbon nanotube / chitosan / magnetic ferrite nanoparticle composite material. A preparation method of the material comprises the following steps of: coating chitosan polymer and magnetic ferrite nanoparticles on multi-wall carbon nanotubes from inside to outside in turn; modifying the surfaces of the carbon nanotubes by coating the chitosan; and depositing the magnetic ferrite nanoparticles on the carbon nanotubes in situ by a hydrothermal method. The material prepared by the method has higher saturation magnetization rate and T2 relaxation coefficient, and is a good magnetic resonance imaging contrast medium. In the invention, concentrated acid oxidation treatment is not required to be performed on the carbon nanotubes in advance, so that the structural integrity of the carbon nanotubes is protected; and the preparation method has the advantages of readily available raw materials, low cost and the like, is easy to operate and is suitable for industrial production.

Description

technical field [0001] The invention relates to a carbon nanotube / chitosan / magnetic ferrite nanoparticle composite material and its preparation method and application, belonging to the technical field of nanocomposite materials. Background technique [0002] Carbon nanotubes have been a research hotspot at home and abroad because of their excellent mechanical, thermal and electrical properties. In recent years, the application of magnetic nanoparticles in carrying drugs and magnetic resonance contrast agents has become a research hotspot. Among these applications, the problems of water solubility and biocompatibility of nanoparticles are mainly to be solved. In order to solve these problems, people wrap some macromolecules such as PEG on the surface of nanoparticles, or use SiO 2 Come to the package and get some grades. [0003] Carbon nanotubes have good biocompatibility, and they are excellent carriers of nanoparticles. However, there are few reports on the preparation...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K49/12A61K49/08A61K49/18
Inventor 吴惠霞刘刚张豪强杨仕平
Owner SHANGHAI NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap