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Lauric acid diethanolamide and application of analog thereof

A technology of lauric acid diethanolamide and its analogues, which is applied in the field of medicine and can solve the problems of reduced therapeutic effect and loss of therapeutic effect of antibiotics, etc.

Inactive Publication Date: 2011-05-04
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, with the increase in the use of antibiotics and the abuse of antibiotics caused by people's dependence on antibiotics, more and more microorganisms have acquired drug resistance, which greatly reduces the therapeutic effect of the original antibiotics, or even loses the therapeutic effect

Method used

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  • Lauric acid diethanolamide and application of analog thereof
  • Lauric acid diethanolamide and application of analog thereof
  • Lauric acid diethanolamide and application of analog thereof

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Embodiment 1

[0017] The present invention measures the minimum inhibitory concentration of lauric acid diethanolamide, berberine hydrochloride and their different ratios. Micro-liquid dilution method (double dilution) was used to treat Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Pseudomonas aeruginosa under the conditions of diethanolamide laurate, berberine hydrochloride and the two different ratios. The minimum inhibitory concentration has been measured, the experimental bacteria concentration: 2.0-3.0 × 10 5 CFU / ml, the results are shown in Table 1.

[0018] Table 1 The minimum inhibitory concentration results of diethanolamide laurate, berberine hydrochloride and their different ratios (unit: μg / ml)

[0019]

[0020] Note: The data in this table are the comprehensive results of two parallel determinations

[0021] the result shows:

[0022] 1. The antibacterial effect of lauric acid diethanolamide on Escherichia coli, Staphylococcus aureus, Bacillus subtilis an...

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PUM

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Abstract

The invention belongs to the technical field of medicines, and relates to lauric acid diethanolamide and application of analog thereof, in particular to lauric acid diethanolamide, antibacterial activity of analog thereof, and application to strengthening of antibacterial activity of an antibacterial agent. The lauric acid diethanolamide and the analog thereof have structural general formulae shown as graphs (I and II) in the specifications, wherein the R group in the graph II is a straight-chain and branched alkyl groups with the 2 to 6 carbon atoms. The compounds have stable structures, and the compounds and the proper medical auxiliary materials are mixed so as to prepare various clinically acceptable preparations. Antibacterial experiment results prove that: the compounds have strong antibacterial activity, the effect of strengthening the antibacterial activity of the antibacterial agent to certain extent, and the advantages of strong activity, small dosage and the like. The lauric acid diethanolamide and the analog thereof can be used for preparation of antimicrobial medicaments and application of synergist of the antibacterial agent to preparation of the antimicrobial medicaments.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to the application of lauric acid diethanolamide and its analogs, in particular to the antibacterial activity of lauric acid diethanolamide and its analogs and the application of enhancing the antibacterial activity of antibacterial agents. Background technique [0002] Microorganisms, especially pathogenic microorganisms, are one of the main causes of human diseases. During the struggle between humans and microorganisms, the discovery of antibiotics has temporarily freed people from the threat of microorganisms to human life. However, with the increase in the use of antibiotics and the abuse of antibiotics caused by people's dependence on antibiotics, more and more microorganisms have acquired drug resistance, which greatly reduces the therapeutic effect of the original antibiotics, or even loses the therapeutic effect. Therefore, the discovery of new antibiotics and synergists of an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/164A61P31/00A61P31/04C07C233/18C07C231/02
Inventor 裴月湖陈刚许颖华会明白皎王海峰
Owner SHENYANG PHARMA UNIVERSITY
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