Preparation method of 1-(2,2-difluoroethoxy)-6-trifluoromethyl-N-([1,2,4]triazolezol[1,5-C] pyrimidine-2-)benzsulfamide
A technology of difluoroethoxy and trifluoromethyl, which is applied in the field of preparation of 1--6-trifluoromethyl-N-benzenesulfonamide, can solve the problems of low marketability and high price, and achieve Improvement of reaction time and yield, reduction of production cost, and simplification of reaction conditions
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[0054] 1 Synthesis of compound VI
[0055]
[0056] Take a 500ml three-neck reactor, put it into a stirring bar, add 40g m-trifluoromethylphenol, add 210ml dichloromethane, add 100ml N,N-diisopropylethylamine, and stir. Under an ice bath, take 46ml of chloromethoxymethyl ether and slowly add it dropwise with a constant pressure dropping funnel. When dripping, the color changes from green to yellow, and finally to orange-purple, and fog occurs. After dripping, at regular intervals, use a UV lamp, use a silica gel plate to track the reaction, and find that the reaction is slow, and stir overnight at room temperature. Afterwards, dichloromethane was evaporated under reduced pressure, and then distilled under reduced pressure with an oil pump to collect a stable fraction at 68°C. 36.7 g of the product was obtained with a yield of 72%. 1 H-NMR (400MHz, CDCl 3 )δ: 7.42(m, 1H), 7.31-7.23(m, 3H), 5.23(s, 2H), 3.51(s, 3H). 13 C-NMR (100MHz, CDCl 3 )δ: 157.5, 132.1, 129.9, 123....
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