Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compound preparation of diclofenac sodium and triptan medicines for treating migraine

A technology of diclofenac and compound preparations, which is applied in the field of medicine, can solve the problems such as the pathogenesis and molecular mechanism of migraine are not very clear, and achieve the effect of reducing adverse reactions, small side effects, and treating migraine

Inactive Publication Date: 2011-04-13
邬林祥 +1
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The molecular mechanisms underlying the pathogenesis and pathology of migraine are not well understood

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound preparation of diclofenac sodium and triptan medicines for treating migraine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-28

[0010] Embodiments 1-28 are listed as follows:

[0011] In the examples, the conventional methods in the pharmaceutical industry were used, and the formulations in the following table were added with pharmaceutically acceptable carriers to prepare tablets.

[0012] Example

[0013] 17

Embodiment 29

[0014] Example 29: A curative effect test of a diclofenac compound preparation for treating migraine according to the present invention:

[0015] The following will illustrate the therapeutic effect of the pharmaceutical composition of the present invention on migraine through human pharmacodynamic experiments.

[0016] 1. General information:

[0017] Among the 280 clinical cases of migraine patients, 100 cases were aged 20-35 years old; 100 cases were aged 35-50 years old; 80 cases were aged 50-65 years old. The disease course of the selected cases should be at least one year, and the history of headache attacks in the past 3 months should be relatively clear. The selected cases were required to have not used migraine treatment drugs in the past 1 month to avoid the influence of other drugs on this test. The seizures of the selected cases should be at least 2 times a month, usually 2-6 times a month.

[0018] 2. Diagnostic criteria: According to the "Diagnostic Criteria f...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a compound preparation of diclofenac sodium and triptan medicines for treating migraine, prepared from diclofenac sodium or pharmaceutical salts thereof and any one triptan medicine or pharmaceutical salts thereof used as main ingredients and matched pharmaceutical vectors. The preparation contains 25-4150mg of diclofenac sodium and 1.0-150mg of triptan medicaments. The invention has the advantages of fully exerting the pharmaceutical complementary synergism according to medicament combination, lessening the adverse reaction related to a certain increased dosage and effectively treating migraine. The compound preparation of the invention has the advantages of short course of treatment, rapid effect, less side effect and low cost.

Description

Technical field: [0001] The invention relates to a compound preparation of diclofenac and triptans for treating migraine, belonging to the field of medicines. Background technique: [0002] Migraine is a recurrent pulsating headache and a common disease. Before the attack, there are often auras such as flashing lights, blurred vision, and numbness of the limbs. It takes about a few minutes to an hour for one side of the head to jump and jump. Pain, and gradually intensified, until nausea, vomiting, feeling will be better, in a quiet, dark environment or after sleep headache relief. It may be accompanied by neurological and mental dysfunction before or during the onset of headache. At the same time, it is a progressive disease, often with increasing frequency. Migraine sufferers are more likely than the general population to develop localized damage to the brain that can lead to strokes, according to research. The more migraines they had, the larger the area of ​​the brain...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K45/00A61P25/06A61K31/196
Inventor 邬林祥邬林云
Owner 邬林祥
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com