Application of ginsenoside components to preparation of medicaments for inhibiting activity of alpha-glucosidase

A technology of glucosidase and ginsenoside, which is applied in the field of ginsenoside components in the field of preparing drugs for inhibiting α-glucosidase activity

Inactive Publication Date: 2011-03-30
上海新康制药厂有限公司 +1
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Problems solved by technology

Ginseng is used in many prescriptions of traditional Chinese medicine to treat diabetes. In recent years, research and application of clinical diabetes drugs, such as Shenqi Xiaoke Granules, Sanxiaozhi, and Yikangwang, all use ginseng as the king drug, but ginsenosides Inhibition of α-glucosidase activity has not been reported

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  • Application of ginsenoside components to preparation of medicaments for inhibiting activity of alpha-glucosidase
  • Application of ginsenoside components to preparation of medicaments for inhibiting activity of alpha-glucosidase

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Embodiment Construction

[0007] The present invention is further described below:

[0008] 1. Sample Preparation

[0009] ①. Preparation of total ginseng saponins sample solution:

[0010] 100 grams of ginseng coarse powder was extracted with 1000 ml of 50% ethanol in a water bath for 3 times, each time for 2 hours, the extracts were combined, the ethanol was recovered under reduced pressure, the water liquid was precipitated by adding 3 times of 95% ethanol, filtered, and the filtrate was evaporated to dryness under reduced pressure to obtain ginseng total saponins. Take 10 mg of dry total ginsenosides and place them in a 10 ml volumetric flask, dissolve with dimethyl sulfoxide to constant volume to obtain a total ginseng saponins sample liquid;

[0011] ②, Ginsenoside Rb 1 Also dissolved in dimethyl sulfoxide to make 1mg / ml sample solution;

[0012] ③, Ginsenoside Rg 1 Also dissolved in dimethyl sulfoxide to make 1mg / ml sample solution;

[0013] ④, Ginsenoside Rg 3 Also dissolved in dimethyl ...

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Abstract

The invention belongs to the technical field of application of traditional Chinese medicines, relates to application of ginsenoside components to the preparation of medicaments for preventing and treating diabetes, in particular to application of the ginsenoside components to the preparation of medicaments for inhibiting the activity of alpha-glucosidase. The ginsenoside components at least comprise total ginsenosides, total saponins of American ginseng, total saponins of notoginseng root, ginsenoside Rb1, ginsenoside Rg1, ginsenoside Rg3, ginsenoside Re, ginsenoside Rh1 and notoginsenoside R1. Experiments prove that the ginsenoside components have obvious effect of inhibiting the activity of the alpha-glucosidase.

Description

technical field [0001] The invention belongs to the technical field of application of traditional Chinese medicines, and relates to the use of ginsenoside components in the preparation of anti-diabetic drugs, in particular to the use of ginsenoside components in the preparation of drugs for inhibiting alpha-glucosidase activity. Background technique [0002] Ginseng is a traditional Chinese medicine for invigorating qi and blood. It has various physiological activities and can prevent and treat various diseases. Studies have shown that ginsenoside is the main active ingredient in ginseng. So far, more than 40 kinds of saponin components have been isolated from ginseng, mainly ginsenoside Rb 1 , Ginsenoside Rg 1 , Ginsenoside Rg 3 , Ginsenoside Re, Ginsenoside Rh 1 et al. reported that ginsenoside Rb 1 It has anti-inflammatory, inhibiting edema, inhibiting virus, inhibiting tumor growth, improving fatigue, and promoting memory; ginsenoside Rg 1 It can significantly impro...

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Application Information

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IPC IPC(8): A61K36/258A61P3/10A61K31/704
Inventor 宋纯清叶晓平茅仁刚
Owner 上海新康制药厂有限公司
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