Bioartificial liver support system and combined type liquid storage tank thereof

Abstract

The invention discloses a bioartificial liver support system and a combined type liquid storage tank thereof, wherein the combined type liquid storage tank comprises a closed liquid inlet tank and a closed liquid return tank; the top of the liquid inlet tank is provided with a first liquid inlet and a first air pressure balancing hole; the bottom of the liquid inlet tank is provided with a first liquid outlet and a second liquid inlet; the top of the liquid return tank is provided with a third liquid inlet and a second air pressure balancing hole; the bottom of the liquid return tank is provided with a second liquid outlet and a third liquid outlet; and the second liquid outlet is communicated with the second liquid inlet by a first communicating pipe which is provided with a direction and flow control device. The invention can improve material interchange efficiency between hepatic failure blood plasma and a bioreactor, avoids futile cycle, does not need to depend on the chimney effect of pumps, has simple structure and stable operation and has improvement of the bioartificial liver support system. In the invention, volume of the liquid inlet tank and the liquid return tank can be adjusted according to specific requirements to suit clinical application.

Description

technical field [0001] The invention relates to a medical device for treating a bioartificial liver, in particular to a device capable of effectively improving the treatment effect of a bioartificial liver and a combined liquid storage tank thereof, belonging to the technical field of biomedicine. Background technique [0002] The bioartificial liver support system is a device that provides extracorporeal liver function support for patients with liver failure. The emergence of this technology has opened up a new way for the treatment of liver failure. The basic principle is to place primary hepatocytes isolated in vitro (pig hepatocytes, human hepatocytes, etc.) or hepatocyte lines cultured in vitro (immortalized hepatocyte lines, etc.) Through material exchange between the semipermeable membrane with a certain molecular cutoff and liver cells, the therapeutic purpose of correcting metabolic disorders can be achieved. In this field, research on cell sources and bioreactors ...

AI Technical Summary

Problems solved by technology

The relatively mature bioartificial liver support systems that have been developed abroad include AMC-BAL, BLSS, ELAD, HepatAssist, MELS, etc. There are roughly two types of problems: 1) The speed of liver failure plasma flowing through the bioreactor is not installed. It can only be consistent with the extraction speed of hepatic failure plasma from the patient's body, and the extraction speed of plasma from the liver failure patient is strictly limited according to the patient's physiological condition, which affects the material exchange between the liver failure plasma and the bioreactor efficiency

2) Using a single-chamber liquid reservoir, although the speed of hepatic failure plasma flowing through the bioreactor can greatly exceed the extraction speed of hepatic failure plasma from the patient's body, the purified plasma that has flowed through the bioreactor is different from that that has not flowed through the bioreactor. The hepatic failure plasma is directly mixed, and it is unavoidable that part of the hepatic failure plasma returns to the patient without interacting with the liver cells in the bioreactor. The existence of ineffective circulation is its serious defect

However, in the process of bioartificial liver treatment using the double-chamber reservoir, the one-way flow between the purified plasma that has been treated by the bioreactor and the hepatic failure plasma that has not been treated by the bioreactor is realized by the suction of the pump. Yes, the one-way flow of plasma in the double chamber will be disturbed in the event of mechanical failures such as unexpected pump stop and operating errors

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