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Preparation method of alpha-mangostin

A technology of mangostin and bamboo, which is applied in the field of preparation of mangostin extraction from plants, can solve the problems of not extracting mangostin industrialized production process disclosure, etc., and achieve the benefits of large-scale production operations, less pollution, and less energy consumption Effect

Inactive Publication Date: 2011-01-26
SUZHOU PAITENG BIOLOGICAL MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In the prior art, there is no disclosure of an industrialized production process for extracting mangostin

Method used

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  • Preparation method of alpha-mangostin

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Get mangosteen husk 10Kg, pulverize, add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 2%, the extraction pressure is 50MPa, the temperature is 100°C, and the CO 2 The flow rate is 10L / min, the extraction time is 80min, and the extract is obtained, which is added to the chromatographic column of nylon 6 polyamide, and is eluted with a mixed solvent of dichloromethane and methanol with a volume ratio of 8:1 as the eluent, and a part of the eluted The liquid point is developed on the polyamide film with the above-mentioned eluent as a supporting detection, and the fraction corresponding to Rf=4-4.5 on the polyamide film is collected, the solvent is recovered, crystallized, separated and crystallized, recrystallized with toluene, separated Crystallization, washing and drying yielded 35.8 g of mangostin, which was detected by HPLC with a purity of 97.6%.

Embodiment 2

[0020] Get mangosteen husk 10Kg, pulverize, add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 80MPa, the temperature is 120°C, and the CO 2 The flow rate is 30L / min, the extraction time is 100min, and the extract is obtained, which is added to a polyamide 6 polyamide chromatography column, and eluted with a mixed solvent of dichloromethane-methanol with a volume ratio of 8:1 as the eluent, and part of the washed The liquid removal point is developed on the polyamide film with the above-mentioned eluent as a supporting detection, and the fraction corresponding to Rf=4-4.5 on the polyamide film is collected, the solvent is recovered, crystallized, separated and crystallized, recrystallized with toluene, The crystals were separated, washed and dried to obtain 40.0 g of mangostin, which was detected by HPLC with a purity of 96.2%.

Embodiment 3

[0022] Get mangosteen husk 10Kg, pulverize, add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 3%, the extraction pressure is 60MPa, the temperature is 110°C, and the CO 2 The flow rate is 20L / min, the extraction time is 90min, and the extract is obtained, which is added to the polyamide 6 polyamide chromatography column, and is eluted with a dichloromethane-methanol mixed solvent with a volume ratio of 8:1 as the eluent. The liquid removal point is developed on the polyamide film with the above-mentioned eluent as a supporting detection, and the fraction corresponding to Rf=4-4.5 on the polyamide film is collected, the solvent is recovered, crystallized, separated and crystallized, recrystallized with toluene, The crystals were separated, washed and dried to obtain 38.3 g of mangostin, which was detected by HPLC with a purity of 98.8%.

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Abstract

The invention relates to a preparation method of alpha-mangostin and the method has simple operation, low pollution and less energy consumption. The method comprises the following process steps: taking the shells of Garcinia mangostana Linn. to grind, adding the grinded shells in a CO2 supercritical extractor, using ethanol as the entrainer to obtain an extract; adding the extract in a polyamide chromatography column, using a mixed solvent of dichloromethane and methanol in a volume ratio of 8:1 as the eluting agent to perform elution, performing matching detection by drop a part of eluent on a polyamide film and using the eluting agent for developing, collecting the fluid phase which has 4-4.5 of Rf on the polyamide film, recycling the solvent, crystallizing, separating the crystals, recrystallizing with toluene, separating the crystals, washing and drying. By adopting the method of the invention to prepare alpha-mangostin, the product purity is high and the industrial amplification production is easy to realize.

Description

technical field [0001] The invention relates to a preparation method of mangostin, in particular to a preparation method of extracting mangostin from plants. Background technique [0002] Mangostin (α-Mangostin), molecular formula: C24H26O6, molecular weight: 410.466, CAS accession number: 6147-11-1, mainly exists in Garcinia mangostana Linn. of Garcinia mangostana, and its molecular formula is as follows: [0003] [0004] Mangosteen is a plant of the genus Mangosteen in the family Garcinia, also known as mangosteen, phoenix fruit or mangosteen. It is a tropical evergreen medium-sized tree, 10-20m high, with dark brown bark, beautiful tree shape, opposite single leaves, and leathery leaves , when the fruit is ripe, it is purple-red, and the pulp is white and transparent; it is native to the Malaysian archipelago and is now distributed in Indonesia, the Philippines, Myanmar, Malaysia, Vietnam, Thailand, Ceylon, China and other places. [0005] The bark, shell, pulp, hear...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/86
CPCY02P20/54
Inventor 王峰王琳张发成
Owner SUZHOU PAITENG BIOLOGICAL MEDICAL TECH
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