Modified polyethylene glycol superoxide dismutase (mPEG-SOD) nanoemulsion capable of being directly externally used for skin and preparation method thereof
A technology of PEGylation and superoxide, applied in the field of medicine, can solve the problems of difficult to achieve therapeutic effect and low SOD transdermal rate, so as to promote transdermal absorption, solve low absorption rate and improve utilization rate Effect
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[0109] Embodiment 1: A kind of preparation method of the pegylated superoxide dismutase (mPEG-SOD) nanoemulsion that can directly skin external application
[0110] A preferred proportion by weight of each raw material of a pegylated superoxide dismutase (mPEG-SOD) nanoemulsion that can be directly used externally on the skin is:
[0111] 7 parts isopropyl myristate
[0112] Caprylic capric macrogol glyceride 30 parts
[0113] Polyglyceryl-3-dioleate 10 parts
[0114] 50 parts of mPEG-SOD aqueous solution
[0115] Vitamin E 3 parts
[0116] A specific preparation method of a pegylated superoxide dismutase (mPEG-SOD) nanoemulsion that can be directly applied externally to the skin (taking the preparation of 100g as an example):
[0117] ① Preparation of mPEG-SOD aqueous solution: Dissolve 0.015g mPEG-SOD in 49.985g distilled water. This solution is used as the water phase (I) 50g;
[0118] ② Accurately weigh 7g of isopropyl myristate with an analytical balance, put it in ...
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