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Low temperature plasma probe and methods of use thereof

A low-temperature plasma and probe technology, applied in the field of ion probes, can solve problems such as unsatisfactory in-situ application, and achieve the effects of light weight, cost saving and portability

Inactive Publication Date: 2011-01-12
PURDUE RES FOUND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The electrospray-based ambient ionization sources described above have the problem that they require electrospray solvents and high-velocity auxiliary gas flows, or additional laser devices to make the ionization source work
The continuous supply of solvents and gases, and associated vessel and waste disposal requirements of electrospray-based methods make them less than ideal for in situ applications

Method used

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  • Low temperature plasma probe and methods of use thereof
  • Low temperature plasma probe and methods of use thereof
  • Low temperature plasma probe and methods of use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Example 1: LTP Probe Instrument

[0083] The LTP probe consists of a housing containing a glass tube (O.D.: 6.35mm, I.D.: 3.75mm) with an axially central electrode (stainless steel, diameter: 1.57mm) and an outer electrode (copper tape) surrounding the outside of the tube . When an AC high voltage is applied to the outer electrodes and the center electrode is grounded, a dielectric barrier discharge area is formed.

[0084] A discharge gas is fed through the tube of the probe and used as a source of reagent ions - electrons, free radicals, excited neutrons and metastable species. figure 1 A diagram of the LTP probe instrument. The probe is powered by a custom power supply with variable frequency and voltage. In this power supply, a square wave with adjustable frequency and amplitude is formed by a digital circuit. The square wave is then amplified using a power amplifier and the ignition coil of a motor vehicle internal combustion engine. Typical excitation voltage...

Embodiment 2

[0086] Example 2: Construction of an LTP probe with a mass spectrometer

[0087]The data for the examples herein were obtained using a Thermo LTQ linear ion trap mass spectrometer (Thermo Scientific, San José, CA, USA) tuned for optimal detection of the analyte precursor ions. Data were acquired by the instrument's Xcalibur software. LTP-MS analysis of the investigated compounds was performed in positive and negative ion modes. Set up the instrument to collect spectra in automatic gain control mode with a maximum ion trap injection time of 200 ms and 2 microscans per spectrum. The main experimental parameters used are as follows: m / z range 150-600; ion spray voltage: 4.5 kV; capillary temperature: 200°C; tube lens (tube len) (V): -65V; capillary voltage: -15V. Tandem mass spectrometry (MS / MS) is performed using collision-induced dissociation (CID) to confirm the presence or absence of a particular chemical in a sample of interest. These tests were performed using an isolati...

Embodiment 3

[0088] Example 3: Chemical properties of LTP

[0089] It was observed that the energies involved in LTP ionization and desorption varied over a wide range and complex chemical processes occurred. As an example, by LTP and using He or N 2 Methyl salicylate vapor in the air was ionized as a discharge gas, and different degrees of fragmentation were observed ( figure 2 Panels A and B in ).

[0090] Only use N 2 Fragment ion m / z 121 was not observed with He, in which case LTP is thought to provide the metastable species with the highest internal energy. This suggests that other mechanisms besides Penning ionization may be involved. Use H3O + The proton transfer is also not expected to produce such results, where H3O + It is produced by Penning ionization of water in air. Collisions of ions at atmospheric pressure might have caused this, or another hypothesis might have been by involving N 2 + or O 2 + Ionization occurs due to charge transfer (Leveille, V.; Coulombe, S....

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Abstract

The present invention generally relates to a low temperature plasma probe for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. In one embodiment, the invention generally relates to a low temperature plasma probe including: a housing having a discharge gas inlet port, a probe tip, two electrodes, and a dielectric barrier, in which the two electrodes are separated by the dielectric barrier, in which application of voltage from a power supply generates a low temperature plasma, and in which the low temperature plasma is propelled out of the discharge region by the electric field and / or the discharge gas flow.

Description

[0001] related application [0002] This PCT application is related to and claims priority from US Provisional Patent Application Serial No. 61 / 028,035, filed February 12, 2008, which is hereby incorporated by reference in its entirety. technical field [0003] The present invention generally relates to low temperature plasma probes for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. Background technique [0004] In analytical chemistry, the increasing need for direct sampling at ambient conditions has prompted the development of a variety of ambient ionization sources. An ambient ionization source ionizes the analyte under various environmental conditions (in situ) with no essential requirements for sample preparation. This advantage allows real-time on-site inspection, saving time and resources. [0005] The potential benefits offered by electrospray-based ambient ionization sources are far superior to traditional vacuum-based...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/00
CPCH01J27/022H01J49/142H01J49/105H01J49/02H05H1/2406H01J37/32348Y10T436/203332Y10T436/145555Y10T436/173076Y10T436/24Y10T436/147777H05H1/2443H01J37/32009H01J2237/0044H01J37/00H05H1/30H05H2240/10H05H2240/20
Inventor 欧阳证积逊·哈珀尼古拉斯·查理珀罗伯特·库克斯
Owner PURDUE RES FOUND INC
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