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Intravascular stent with medicament carrying groove

A vascular stent and drug-loading technology, which is applied in the field of vascular stents, can solve the problems of unsatisfactory drug spatial distribution, insufficient endothelialization, and stenotic effects, and achieve the effects of large drug effective concentration space, reduced restenosis, and increased release space

Active Publication Date: 2012-12-19
日照天一生物医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Domestic patents also disclose the structure of several grooved stents. The drug is loaded in the groove, and the drug is released to the blood vessel wall at a fixed point. The drug stent with such a structure can avoid the inhibition of endothelialization and insufficient endothelialization of the fully encapsulated drug stent , The problem of adhesion between the polymer and the balloon, but because of the limitation of the drug release space by the groove, the spatial distribution of the drug is not ideal, and the effect of inhibiting restenosis is not as good as that of the fully encapsulated structure

Method used

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  • Intravascular stent with medicament carrying groove
  • Intravascular stent with medicament carrying groove
  • Intravascular stent with medicament carrying groove

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Such as figure 1 with figure 2 As shown, in Embodiment 1 of the present invention, the vascular stent provided with drug-loaded grooves includes a plurality of support rods 1 and a plurality of connecting rods 2 , and the support rods 1 and connecting rods 2 are arranged longitudinally to form a tubular shape. The support rod 1 is a continuous sine wave shape formed by alternately arranged uplink sections and downlink sections, and the crests of the support rods are connected with the troughs of the adjacent support rods through the connecting rod 2 . On the whole support rod 1, there is a continuous drug-loading groove 3. The drug-loading groove 3 is embedded with a mixture coating (the mixture includes a polymer and a drug, and the polymer is used to control the release of the drug); like this, the drug-loading groove 3 can be towards the outside of the support rod 1 (that is, close to the side of the blood vessel wall) side) to release the drug.

[0019] Such as ...

Embodiment 2

[0029] The difference between this embodiment and embodiment 1 is:

[0030] Such as Figure 5 As shown, there are six side drug release ports 4 on the upward and downward segments of the support rod 1, and the six side drug release ports 4 are alternately arranged on the two sides of the drug-loading groove 3.

[0031] The width of the drug-loading groove 3 is 0.06-0.11 mm, preferably 0.075-0.095 mm; the depth of the drug-loading groove 3 is 0.02-0.08 mm, preferably 0.045-0.065 mm; The opening range of the drug-loading groove 3 in the longitudinal direction is 0.1-0.35 mm, and the preferred opening range is 0.20-0.35 mm.

Embodiment 3

[0033] The difference between this embodiment and embodiment 1 is:

[0034] Such as Image 6 As shown, there are eight side drug release ports 4 on the uplink and downlink sections of the support rod 1, and the eight side drug release ports 4 are alternately arranged on the two sides of the drug-loading groove 3.

[0035] The width of the drug-loading groove 3 is 0.06-0.11 mm, preferably 0.075-0.095 mm; the depth of the drug-loading groove 3 is 0.02-0.08 mm, preferably 0.045-0.065 mm; The opening range of the drug-loading groove 3 in the longitudinal direction is 0.1-0.35 mm, and the preferred opening range is 0.15-0.25 mm.

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Abstract

The invention provides an intravascular stent with a medicament carrying groove. The stent comprises a plurality of support rods and a plurality of connecting rods, wherein the support rods and the connecting rods are arranged longitudinally and are tubular; adjacent support rods are connected with each other through the connecting rod; each support rod is provided with the medicament carrying groove which comprises a top opening, and a bottom surface and left and right side faces which are formed by intersecting with the support rod; and at least one side face of the medicament carrying groove of the support rod is provided with a side face medicament release port. In the invention, a medicament space is partitioned into a V-shaped space along the outer side direction (one side tightly close to a vascular wall) of the support rod and a V-shaped space along the cross section direction (the cross section direction of a blood vessel) of the support rod and is closer to an effective medicament releasing space of a fully-coated structure, the medicament releasing period of the structure is longer than the medicament releasing period of the fully-coated structure and the restenosis of a lesion blood vessel is reduced without affecting endothelialization.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a blood vessel stent provided with drug-loading grooves implanted in coronary arteries during the operation for treating cardiovascular diseases. technical background [0002] After coronary stent implantation, about 25% of restenosis occurs, and the emergence of drug stents reduces the probability of restenosis to less than 10%. At present, the mainstream drug stent basically adopts a fully-wrapped structure, that is, the mixture of polymer and drug is evenly wrapped around the cross-section of the stent rod, which is a fixed-point drug delivery method. In this way, on the one hand, the drug inhibits restenosis, and on the other hand, it also inhibits endothelialization. Insufficient endothelialization makes the polymer components on the surface of the stent come into contact with blood and easily cause thrombus. Endothelial cell insufficiency and the lack of biological...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/82A61M31/00
Inventor 郭高东罗兆坤张金峰宫照辉
Owner 日照天一生物医疗科技有限公司
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