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Degradable gel microspheres interposed in bronchus and application thereof

A technology of gel microspheres and bronchial tubes, which is used in medical preparations with non-active ingredients, pharmaceutical sciences, respiratory system diseases, etc., to achieve high reliability and safety.

Inactive Publication Date: 2010-12-15
THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the lung-targeted slow-release and controlled-release drug microspheres cause many lung lesions and respiratory failure in the lungs, this kind of microspheres has not been used in clinical treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A kind of degradable gel microspheres inserted into the bronchi, including hyaluronic acid-calcium alginate gel microspheres and rifabutin chitosan-calcium alginate gel microspheres, the production steps are as follows:

[0040] (1) 4g rifabutin was dissolved in 40mL ethyl acetate to obtain a 10% rifabutin solution by mass fraction;

[0041] (2) Weigh 1.5 g of sodium alginate, 0.3 g of sodium hyaluronate and 0.5 g of glycerin, and dissolve them together in 100 mL of distilled water to obtain a sodium hyaluronate-sodium alginate solution.

[0042] (3) Weigh 2.5g of sodium alginate and dissolve it in 100mL of distilled water to obtain a 2.5% sodium alginate solution;

[0043] (4) Take 0.2g chitosan and dissolve in 100mL of 4% acetic acid solution to obtain 0.2% chitosan solution;

[0044] (5) Calcium chloride is mixed with 1.5% solution to obtain sol coagulation liquid;

[0045] (6) The obtained hyaluronic acid-sodium alginate solution is passed through a high-voltage e...

Embodiment 2

[0052] A kind of degradable gel microspheres inserted into the bronchi, including hyaluronic acid-calcium alginate gel microspheres and rifapentine chitosan-calcium alginate gel microspheres, the production steps are as follows:

[0053] (1) Grind an appropriate amount of dry powder of rifapentine and filter through a 200-mesh sieve.

[0054] (2) Weigh 1.5 g of sodium alginate, 0.3 g of sodium hyaluronate and 0.5 g of glycerin, and dissolve them together in 100 mL of distilled water to obtain a sodium hyaluronate-sodium alginate solution.

[0055] (3) Weigh 2.5g of sodium alginate and dissolve it in 100mL of distilled water to obtain a 2.5% sodium alginate solution;

[0056] (4) Take 0.2g chitosan and dissolve in 100mL of 4% acetic acid solution to obtain 0.2% chitosan solution;

[0057] (5) Calcium chloride is made into a solution with a mass fraction of 2% to obtain a sol coagulation solution;

[0058] (6) Pass the obtained sodium hyaluronate-sodium alginate solution throu...

Embodiment 3

[0064] A kind of degradable gel microsphere intervening in the bronchus, comprising hyaluronic acid-calcium alginate gel microsphere and doxorubicin (doxorubicin) chitosan-calcium alginate gel microsphere, its preparation steps are as follows:

[0065] (1) 6g doxorubicin was dissolved in 40mL ethyl acetate to obtain a 15% doxorubicin solution;

[0066] (2) Weigh 1.5 g of sodium alginate, 0.3 g of sodium hyaluronate and 0.5 g of glycerin, and dissolve them together in 100 mL of distilled water to obtain a sodium hyaluronate-sodium alginate solution.

[0067] (3) Weigh 2.5g of sodium alginate and dissolve it in 100mL of distilled water to obtain a 2.5% sodium alginate solution;

[0068] (4) Take 0.2g chitosan and dissolve in 100mL of 4% acetic acid solution to obtain 0.2% chitosan solution;

[0069] (5) 5g calcium chloride is dissolved in 500mL distilled water, is mixed with 1% calcium chloride solution, obtains sol coagulation liquid;

[0070] (6) The obtained hyaluronic acid...

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Abstract

The invention relates to degradable gel microspheres interposed in a bronchus and application thereof. The degradable gel microspheres comprise hyaluronic acid-calcium alginate gel microspheres and medicament-loaded chitosan-calcium alginate gel microspheres, wherein the hyaluronic acid-calcium alginate gel microspheres and the medicament-loaded chitosan-calcium alginate gel microspheres are mixed together uniformly according to proportion, and the volume ratio is 2:1-9. The degradable gel microspheres can be used for preparing sustained-release and controlled-release medicaments for treatinglung cancer, lung tumor, tuberculosis, pneumonia and bronchitis and a tissue engineering scaffold material. The degradable gel microspheres interposed in the bronchus do not block up a lung bronchus and also do not initiate ischemic necrosis of surrounding tissues of the bronchus, so the degradable gel microspheres can be used as the tissue engineering scaffold material and a medicament sustained-release scaffold. Two types of microspheres with different functions have complementary advantages, overcome the technical difficulties of microsphere blockage and pulmonary ventilation in the bronchus, and can significantly reduce toxic or side effect of medicaments and improve therapeutic indexes of the medicaments.

Description

technical field [0001] The invention relates to a degradable gel microsphere inserted into the bronchi and its application, specifically hyaluronic acid-calcium alginate gel microspheres and drug-loaded chitosan-calcium alginate gel microspheres mixed uniformly in proportion Glue microspheres and their application in the preparation of sustained-release and controlled-release drugs and tissue engineering scaffold materials for treating lung cancer, lung tumors, tuberculosis, pneumonia and bronchitis. Background technique [0002] As we all know, the lung is a respiratory organ that periodically expands and contracts, and the gas reciprocates in the trachea and bronchi. The airway caliber and volume of the respiratory tract change rapidly with the rhythm of breathing. Pulmonary bronchi and alveoli of various sizes constitute the airflow channel with high flow rate and low impedance during breathing. Once a wide range of small airways is obstructed or blocked, hypoxia and resp...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/36A61L27/20A61L31/04A61P11/00A61P31/06A61P35/00
Inventor 张广宇杨楠黎立史迎昌
Owner THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY
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