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Arbidol HCl orally disintegrating tablet and preparation method thereof

A technology of arbidol hydrochloride and disintegrating tablets, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as troublesome taking and poor medication compliance, and achieve convenience Taking, low production cost, fast absorption effect

Inactive Publication Date: 2010-12-08
江西中兴汉方药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Influenza and acute respiratory viral infection are diseases with high clinical incidence and wide range. Children and the elderly are susceptible groups. Arbidol hydrochloride is a new anti-influenza and acute respiratory viral infection drug, but children, The elderly have poor compliance with medication, and because Arbidol is insoluble in water, it brings some troubles to taking it. Orally disintegrating tablets are tablets that can quickly dissolve in the mouth. Usually, the dissolution time does not exceed 1 minute, and no drinking water is required.

Method used

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  • Arbidol HCl orally disintegrating tablet and preparation method thereof

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Comparison scheme
Effect test

Embodiment 1

[0045] 1. Arbidol hydrochloride orally disintegrating tablets are characterized in that the starting materials of the method are composed of the following components, and are counted in parts, and the composition ratio of the raw materials is as follows:

[0046] Raw material formula:

[0047] (1), coating particle part:

[0048] Arbidol hydrochloride 101 parts

[0049] Hydroxypropyl cellulose 5.5 parts

[0050] 25 parts cane sugar powder

[0051] 2% povidone K-30 aqueous solution 60 parts

[0052] (2), coating liquid part:

[0053] Eudragit E100 42 servings

[0054] Polyethylene glycol 6000 15.5 parts

[0055] Magnesium stearate 3.5 parts

[0056] Ethanol 500.0 parts

[0057] (3) Additional accessories:

[0058] Microcrystalline cellulose 30.0 parts

[0059] 7.0 parts of crospovidone

[0060] Croscarmellose sodium 7.0 parts

[0061] Hydroxypropyl cellulose 7.0 parts

[0062] Aspartame 5.0 parts

[0063] 0.2 parts of menthol

[0064] Magnesium stearate 2.0 parts...

Embodiment 2

[0077]1. Arbidol hydrochloride orally disintegrating tablets are characterized in that the starting materials of the method are composed of the following components, and are counted in parts, and the composition ratio of the raw materials is as follows:

[0078] Raw material formula:

[0079] (1), coating particle part:

[0080] Arbidol hydrochloride 103.5 parts

[0081] 6.3 parts of hydroxypropyl cellulose

[0082] Sucrose powder 25.0 parts

[0083] 2% povidone K-30 aqueous solution 80 parts

[0084] (2), coating liquid part:

[0085] Eudragit E100 45.5 parts

[0086] Polyethylene glycol 6000 15.9 parts

[0087] Magnesium stearate 4.6 parts

[0088] Ethanol 593.4 parts

[0089] (3) Additional accessories:

[0090] Microcrystalline cellulose 39.1 parts

[0091] 7.8 parts of crospovidone

[0092] 7.8 parts of croscarmellose sodium

[0093] 7.8 parts of hydroxypropyl cellulose

[0094] Aspartame 6.5 parts

[0095] 0.5 parts of menthol

[0096] 2.6 parts of magnesi...

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Abstract

The invention relates to an arbidol HCl orally disintegrating tablet and a preparation method thereof. The arbidol HCl orally disintegrating tablet comprises the components based on parts by weight: 100.5-105.5 parts of arbidol HCl, 5.0-7.0% of hydroxy propyl cellulose, 20.0-30.0% of cane sugar powder, 50-100 parts of 2% povidone K-30 water solution, 40.5-50.5 parts of Eudragit E100, 15.5-16.5 parts of polyethylene glycol 6000, 3.5-5.5 parts of magnesium stearate, 500.0-700.0 parts of alcohol, 30.0-50.0 parts of microcrystalline cellulose, 7.0-9.0 parts of crosslinking povidone, 7.0-9.0 parts of crosslinking sodium carboxymethylcellulose, 7.0-9.0 parts of hydroxy propyl cellulose, 5.0-7.5 parts of aspartame, 0.2-0.7 part of menthol, 2.0-3.0 parts of magnesium stearate and 2.0-3.0 parts of food colorant. The invention comprises the steps of: pretreatment of raw materials and auxiliary materials, preparation of granules, coating of the granules, tabletting and packaging. The invention has simple technique control, rapid absorption, high bioavailability and convenient taking.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to Arbidol hydrochloride orally disintegrating tablets and a preparation method thereof. Background technique [0002] Influenza and acute respiratory viral infection are diseases with high clinical incidence and wide range. Children and the elderly are susceptible groups. Arbidol hydrochloride is a new anti-influenza and acute respiratory viral infection drug, but children, The elderly have poor compliance with medication, and because Arbidol is insoluble in water, it brings some troubles to taking it. Orally disintegrating tablets are tablets that can quickly dissolve in the mouth. Usually, the dissolution time does not exceed 1 minute, and no drinking water is required. . It absorbs faster than common oral preparations, has high bioavailability and is convenient to take. Contents of the invention [0003] The technical problem solved by the present invention is to p...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/404A61K47/38A61P31/12A61P31/16A61P11/00
Inventor 李卫东
Owner 江西中兴汉方药业有限公司
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