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Famciclovir dispersible tablet and preparation method thereof

A technology of famciclovir and dispersible tablets, which is applied in the field of famciclovir dispersible tablets and its preparation, can solve the problems of low bioavailability and slow onset of action, and achieve the effect of improving clinical application value

Active Publication Date: 2010-12-08
JIANGSU CHENPAI PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] After a lot of experiments and explorations, the present invention is developed into famciclovir dispersible tablets, which solves the shortcomings of traditional dosage forms such as slow onset of action and low bioavailability, and improves its clinical application value in the prevention and treatment of various diseases caused by microvascular circulation disorders

Method used

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  • Famciclovir dispersible tablet and preparation method thereof
  • Famciclovir dispersible tablet and preparation method thereof
  • Famciclovir dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0268] prescription:

[0269] Amount of raw materials used (g)

[0270] Famciclovir 250

[0271] Microcrystalline Cellulose 200

[0272] Sodium carboxymethyl starch 78

[0273] Crospovidone 60 (extra)

[0274] Magnesium Stearate 2.4(1.0%)

[0275] 8% PVPK30 ethanol solution appropriate amount

[0276]

[0277] Makes 1000 pieces

[0278] Preparation Process:

[0279] Accurately weigh the famciclovir raw material, pass through an 80-mesh sieve, add an appropriate amount of absolute ethanol as a binder, stir evenly to prepare a soft material, granulate with a 16-mesh sieve, and dry at 60°C to obtain famciclovir granules for future use.

[0280] Mix microcrystalline cellulose and 30g of sodium carboxymethyl starch evenly, pass through a 80-mesh sieve, add an appropriate amount of 8% PVPK30 ethanol solution as a binder, stir evenly to prepare a soft material, granulate with a 16-mesh sieve, and heat at 60°C Dry to obtain excipient granul...

Embodiment 2

[0282] prescription:

[0283] Amount of raw materials used (g)

[0284] Famciclovir 250

[0285] Pregelatinized starch 300

[0286] Croscarmellose sodium 72 (28g internally, 44g externally)

[0287] Crospovidone 50 (extra)

[0288] Micronized silica gel 0.5%

[0289] 8% PVPK30 ethanol solution appropriate amount

[0290]

[0291] Makes 1000 pieces

[0292] Preparation Process:

[0293] Accurately weigh the famciclovir raw material, pass through a 100-mesh sieve, add an appropriate amount of absolute ethanol as a binder, stir evenly to prepare a soft material, granulate with a 16-mesh sieve, and dry at 60°C to obtain famciclovir granules for future use.

[0294] Mix the pregelatinized starch and croscarmellose sodium added internally, pass through a 100-mesh sieve, add an appropriate amount of 8% PVPK30 ethanol solution as a binder, stir evenly to prepare a soft material, granulate with a 16-mesh sieve, 60 Dry at ℃ to obtain excipient...

Embodiment 3

[0296] prescription:

[0297] Amount of raw materials used (g)

[0298] Famciclovir 250

[0299] Microcrystalline Cellulose 250

[0300] Sodium carboxymethyl starch 78 (30g internally, 48g externally)

[0301] Low-substituted hydroxypropyl cellulose 55 (extra)

[0302] Magnesium Stearate 1.0%

[0303] 8% PVPK30 ethanol solution appropriate amount

[0304]

[0305] Makes 1000 pieces

[0306] Preparation Process:

[0307] Accurately weigh the famciclovir raw material, pass through a 100-mesh sieve, add an appropriate amount of absolute ethanol as a binder, stir evenly to prepare a soft material, granulate with a 16-mesh sieve, and dry at 60°C to obtain famciclovir granules for future use.

[0308] Mix microcrystalline cellulose and internally added sodium carboxymethyl starch evenly, pass through a 100-mesh sieve, add an appropriate amount of 8% PVPK30 ethanol solution as a binder, stir evenly to prepare a soft material, granulate ...

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Abstract

The invention provides a famciclovir dispersible tablet containing famciclovir, disintegrating agents, adhesives and a proper amount of lubricants. Compared with the common famciclovir dispersible tablet, the famciclovir dispersible tablet prepared in the method by adopting a secondary granulation method has the advantages of rapid effect taking and definite curative effect.

Description

technical field [0001] The invention relates to an improved pharmaceutical dosage form of famciclovir, in particular to a famciclovir dispersible tablet and a preparation method thereof, which has faster onset of action, obvious quick-release effect and definite curative effect compared with ordinary famciclovir tablets. Background technique [0002] Famciclovir (Famciclovir), chemical name 2-[2-(2-amino-9H-purin-9-yl) ethyl]-1,3-propanediol-diethyl ester, 2-[2-[9-(2- Amino-9H-purinyl)]ethyl]-1,3-propanediol diacetate; molecular formula is C 14 h 19 N 5 o 4 , the chemical structural formula is: [0003] [0004] Famciclovir is a second-generation ring-opening nucleoside antiviral drug. It is a prodrug discovered from "ACV and GCV" analogs and developed according to pharmacokinetics. Its main activities are: anti-herpes zoster and primary genitalia Herpes, anti-herpes zoster, anti-genital herpes, anti-cold sores; anti-viral spectrum: herpes simplex virus (HSV-1, HSV-2...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/52A61K47/38A61P31/12A61P31/14A61P31/20A61P31/22
Inventor 李建新程浩文苏丽陈泳海徐亮亮
Owner JIANGSU CHENPAI PHARM GRP CO LTD
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