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Traditional Chinese medicine extract with alpha-glucuroide and xanthine oxidase inhibiting effect and preparation method and usage thereof

A technology of xanthine oxidase and glucosidase, which is applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve good results

Inactive Publication Date: 2010-11-17
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Using Shi Jianchuan and Shi Jianchuan respectively with Daxueteng and Rhizoma Drynaria to screen the effects of these two enzyme inhibitors, there is no report

Method used

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  • Traditional Chinese medicine extract with alpha-glucuroide and xanthine oxidase inhibiting effect and preparation method and usage thereof
  • Traditional Chinese medicine extract with alpha-glucuroide and xanthine oxidase inhibiting effect and preparation method and usage thereof
  • Traditional Chinese medicine extract with alpha-glucuroide and xanthine oxidase inhibiting effect and preparation method and usage thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Example 1 A traditional Chinese medicine extract with the function of inhibiting α-glucosidase and xanthine oxidase, 2 parts of water extract or extract or crude polysaccharide of Shi Jianchuan;

[0088] The preparation method is as follows:

[0089] (1) Preparation of the water extract of Ishimichuan: Add 20 times of distilled water to 100g of Ishimichuan medicinal material, cold soak at room temperature for 2 hours, decoct in water for 1 hour, filter, add distilled water and repeat the decoction once; Combine the 2 filtrates, cool to room temperature, centrifuge at 3000rpm / min for 10min, concentrate the supernatant on a boiling water bath, heat and concentrate with distilled water to 0.5g crude drug / mL.

[0090] (2) Preparation of Shijianchuan extract: prepare the water extract according to the above method, add ethanol to the water extract concentrate to reach a concentration of 50vt%, mix well, centrifuge at 3000rpm / min for 10min in a refrigerator at 4°C overnight, ...

Embodiment 2

[0092] Example 2 The Chinese medicine extract that has the effect of inhibiting α-glucosidase and xanthine oxidase is composed of 1 part of Shi Jianchuan and 1 part of Rhizoma Rhododendron, the water extract or extract or crude polysaccharide;

[0093] The preparation method is as follows:

[0094] (1) The preparation of the water extract compatible with Ishii Chuan and Daxueteng: take 50g of Shi Jianchuan and 50g of decoction pieces of Daxueteng, and add medicinal materials 20 times the weight of distilled water, cold soak at room temperature for 2 hours, decoct in water for 1 hour, filter, and add distilled water to the dregs of the medicine and repeat the decoction once. Combine the two filtrates, cool to room temperature, centrifuge at 3000rpm / min for 10min, concentrate the supernatant on a boiling water bath, add distilled water to make up to 0.5g crude drug / mL;

[0095] (2) Preparation of the extract that is compatible with Shi Jianchuan and Daxueteng: prepare the water...

Embodiment 3

[0097] Example 3 The Chinese medicine extract with the effect of inhibiting α-glucosidase and xanthine oxidase consists of 1 part of Shi Jianchuan and 1 part of Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizome.

[0098] The preparation method is as follows:

[0099] (1) Preparation of water extract compatible with Drynaria and Rhizoma: Take 50g of Drynaria and 50g pieces of Drynaria, and add herbs 20 times the weight of distilled water, cold soak at room temperature for 2 hours, decoct in water for 1 hour, filter, and add distilled water to the dregs of the medicine and repeat the decoction once. Combine the two filtrates, cool to room temperature, centrifuge at 3000rpm / min for 10min, concentrate the supernatant on a boiling water bath, add distilled water to make up to 0.5g crude drug / mL;

[0100] (2) Preparation of the extract that is compatible with Rhizoma Drynariae: Prepare the water extract according to the above method, add ethanol to the...

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Abstract

The invention discloses a traditional Chinese extract with alpha-glucuroide and xanthine oxidase inhibiting effect and extracting method and usage thereof. The traditional Chinese medicine is water extract, water extraction and alcohol precipitation supernate concentrated extractum or water extraction and alcohol precipitation polysaccharose of salvia chinensis, or salvia chinensis and sargentg loryvine or salvia chinensis and drynaria rhizome in certain weight proportion respectively. The traditional Chinese medicine extract has alpha-glucuroide inhibiting effect and can be used for treating glucose tolerance defect, 2-type diabetes and obesity; and the traditional Chinese medicine extract also has xanthine oxidase inhibiting effect and can be used for treating hyperuricemia and gout.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine extract capable of inhibiting alpha-glucosidase and xanthine oxidase, a preparation method and application thereof. Background technique [0002] "Guidelines for the Prevention and Treatment of Type 2 Diabetes in China in 2007" pointed out that the number of people with diabetes in my country has accounted for 1 / 3 of the world, ranking second in the world. In the past 20 years, the prevalence of type 2 diabetes in my country has increased by 4 times in the past 20 years , the prevalence rate in urban areas is 4.5%, and that in rural areas is 1.8%, which is similar to the data of countries with the same level of development [1. China Type 2 Diabetes Prevention Guidelines Development Committee. China Type 2 Diabetes Prevention Guidelines 2007 Edition [EB]. http: / / www.docin.com / p-7167841.html.]. [0003] The occurrence ...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P3/04A61P3/10A61P19/06
Inventor 吴慧平陈美娟许婷婷陈建伟严令耕倪荷芳戴晓明詹瑧席蓓莉赵凤鸣李萍赵玉荣
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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