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Medicinal composition for preventing and treating rheumatoid arthritis and preparation method thereof

A rheumatoid, composition technology, applied in the direction of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc.

Inactive Publication Date: 2011-09-14
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Make decoction of the above medicine and take it orally, one dose per day; CN101468136 patent application discloses 12g of Angelica, 10g of Radix Paeoniae Alba, 10g of Cortex Wujiapi, 15g of Dipsacus Radix, 8g of Huangda, 12g of Clematis, 7g of Chuanhuanglian, Akebia 5g, Epimedium 10g, Snake 3g, Scorpion 5g, Achyranthes bidentata 10g, Guizhi 12g, Myrrh 10g, Duhuo 5g, Anemarrhena 10g, Atractylodes 6g, Fangfeng 15g, Nuxychia 10g, bone fragments The traditional Chinese medicine preparation for the treatment of RA made by adding 15g; CN101601818 patent application discloses 24-66 parts of angelica, 35-75 parts of Gastrodia elata, 24-66 parts of Achyranthes bidentata, 35-75 parts of safflower, 24-66 parts of myrrh, 12 to 48 parts of frankincense, 12 to 48 parts of atractylodes rhizome, 12 to 48 parts of notopterygium, and 24 to 66 parts of lovage are medicinal preparations for the treatment of RA made of raw materials; 6-12), donkey-hide gelatin (6-12), jujube kernel (9-15), Xu Changqing (9-18), asarum (2-5), angelica (9-15), cinnamon (2-5), clove (3-8), Black Snake (5-10), White Snake (3-6), Qianghuo (9-15), Duhuo (9-15), Xungufeng (9-18), Bergamot (9-15) 18), licorice (3-9), ligusticum edulis (9-15) and myrrh (6-10), mix the above-mentioned traditional Chinese medicines according to the proportion, grind them through a 60-100 mesh sieve, and make powder according to the routine , sterilize the Chinese medicine powder that is crushed into fine powder and put it into capsules, each capsule is 0.45 grams of Chinese medicine capsules; the formation and development of rheumatoid arthritis is an extremely complicated process. There is still no definitive treatment, so it is the desire of the majority of patients to develop a generally recognized traditional Chinese medicine compound for the treatment of rheumatoid arthritis

Method used

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  • Medicinal composition for preventing and treating rheumatoid arthritis and preparation method thereof
  • Medicinal composition for preventing and treating rheumatoid arthritis and preparation method thereof
  • Medicinal composition for preventing and treating rheumatoid arthritis and preparation method thereof

Examples

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Effect test

example 1

[0062] Example 1: Granules

[0063] Prescription: Snakevine 25g, Notopterygium 20g, Gentiana 15g, Sangji 10g, Fangfeng 10g, Achyranthes bidentata 10g, Zhilicorice 6g.

[0064] Preparation method: Take the raw medicine according to the prescription and extract it with water for 3 times, add 10 times of water to decoct for 3 hours each time, then combine the decoction liquid, filter, and finally concentrate the filtrate to an extract with a relative density of 1.50, first press the extract of the extract Add 4 times the weight of dextrin, dry it in vacuum at 80°C, crush it through a 65-mesh sieve to obtain a dry powder, then add 2 times the weight of powdered sugar according to the weight of the dry powder, use 95% ethanol as a wetting agent to make a soft material, and pass through a 16-mesh Sieve and granulate, dry, granulate, and pack into 10g packs.

[0065] Dosage: 10g each time, 2 times a day, take it with warm water.

example 2

[0066] Example 2: Tablet

[0067] Prescription: Snakevine 17g, Notopterygium 14g, Gentiana 8g, Sangji 18g, Fangfeng 8g, Achyranthes bidentata 8g, Zhigancao 5g

[0068] Preparation method: extract the raw material medicine with water for 3 times according to the prescription, add 12 times of water each time and decoct for 1 hour, then combine the decoction liquid, filter, and finally concentrate the filtrate to an extract with a relative density of 1.49, first press the extract Add 4 times the weight of dextrin, dry it in vacuum at 80°C, crush it through a 65-mesh sieve to obtain a dry powder, then add 2 times the weight of powdered sugar according to the weight of the dry powder, use 95% ethanol as a wetting agent to make a soft material, and pass through a 16-mesh Sieve and granulate, dry, and compress into tablets by conventional methods to make tablets.

[0069] Dosage: Take orally, 4 tablets at a time, 3 times a day.

example 3

[0070] Example 3: Capsules

[0071] Prescription: Snakevine 40g, Notopterygium 30g, Gentiana 20g, Sangji 15g, Fangfeng 16g, Achyranthes bidentata 16g, Zhilicorice 6g

[0072] Preparation method: extract the raw material drug with water twice according to the prescription, add 8 times of water to decoct for 3 hours each time, then combine the decoction liquid, filter, and finally concentrate the filtrate to an extract with a relative density of 1.12. Add 4 times the weight of dextrin, dry it in vacuum at 80°C, crush it through a 65-mesh sieve to obtain a dry powder, then add 2 times the weight of powdered sugar according to the weight of the dry powder, use 95% ethanol as a wetting agent to make a soft material, and pass through a 16-mesh Sieve and granulate, dry, granulate, pack into gelatin capsules, and make capsules.

[0073] Dosage: Take orally, 4 capsules at a time, 3 times a day.

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Abstract

The invention relates to a Chinese patent medicament taking plants as raw materials, in particular to a medicinal composition for preventing and treating rheumatoid arthritis. The medicament consists of active ingredients and pharmaceutically acceptable auxiliary materials. The medicinal composition is characterized in that the active ingredients are prepared from the following raw material medicaments in percentage by weight: 15 to 50 percent of celastrus orbiculatus, 10 to 40 percent of incised notopterygium rhizome, 5 to 20 percent of radix gentianae macrophyllae, 5 to 25 percent of Chinese taxillus twig, 5 to 20 percent of divaricate saposhnikovia root, 5 to 20 percent of two-tooth achyranthes root and 5 to 10 percent of prepared licorice root. Seven gouts of medicaments of the whole formula of the medicament are matched to play a role in clearing heat and expelling wind, activating meridians and stopping pain together, and the medicament has the advantages of easily obtained medicinal materials and moderate price.

Description

field of invention [0001] The invention relates to a medical preparation, in particular to a Chinese patent medicine with plants as raw materials. Background technique [0002] Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammatory lesions in joints and periarticular tissues, which seriously endangers human health and is a clinically frequently occurring and difficult disease. According to statistics, the incidence rate in foreign countries is about 1% to 2%, and it is as high as 5% in some regions. The incidence rate in various parts of our country is slightly different, with an average of 0.4%. Based on this incidence rate, the total number of patients in my country is as high as 4 to 5 million. It has been reported that the disability rate of RA patients who are not diagnosed and treated in time reaches 50% in two years and 70% in three years. Compared with their peers, the life expectancy of RA patients is shortened by 10-15% on average...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/51A61P19/02A61P19/04A61P29/00
Inventor 袁立霞
Owner SOUTHERN MEDICAL UNIVERSITY
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