Compound with functions of blocking cholesterol esterification and lowering cholesterol
A cholesteryl ester and compound technology, applied in the field of compounds, can solve the problems of poor human body tolerance, myocardial damage, skin flushing, etc., and achieve the effects of increased effectiveness, stable action and wide adaptability
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[0022] 1. Preparation and detection of cholestane submicroemulsion:
[0023] Prescription composition: 5α-cholesterane, soybean oil for injection, medium chain oil for injection, lecithin for injection, puloxamer F127, oleic acid, glycerin, water.
[0024] Process: Dissolve 5α-cholesterane in soybean oil, add medium-chain oil and oleic acid and mix to obtain an oil phase, add appropriate amount of lecithin, glycerin, and puloxamer into water and ultrasonically disperse it as the water phase, and vortex After mixing the oil phase and water phase, high-speed shearing for 3 minutes to obtain colostrum, high-pressure homogenizer for 2-3 cycles. Boil for 30 minutes to sterilize. Particle size and zeta potential were measured by Malvern particle size analyzer.
[0025] 2. The lipid-lowering effect of cholesterol liposome on high-fat-fed rabbit model.
[0026] A. Replication of animal model of atherosclerosis:
[0027] Adaptive feeding for 1 week, after observing no abnormality, ...
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