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Method for preparing microcapsule taking hydrophobic substance as core material by complex coacervation method

A technology of composite coacervation and hydrophobic substances, which is applied in the field of preparation of microcapsules, can solve the problems of large differences, low stability, and high price, and achieve the effects of good spherical shape, uniform particle size, and reduced total cost

Inactive Publication Date: 2010-10-13
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gum Arabic is secreted from the trunks of Acacia trees and Acacia trees. Due to the limitation of the origin of such plants, Gum Arabic can only rely on imports, and the price is high. At the same time, the characteristics of plant sources make it different brands and different batches. There is a large difference between them, and the stability is not high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Weigh 7.2g of gelatin and 0.8g of carboxymethyl cellulose, add 800ml of deionized water, stir and dissolve in a 60°C water bath. Weigh 8g of cinnamaldehyde, add it into the wall material solution, disperse and homogenize at high speed for 2 minutes. The speed of the disperser is 10000r / min. Stir at a constant temperature of 45°C with a stirring speed of 400r / min. 10% acetic acid solution was added to adjust the pH to 4.6, and the reaction was stirred for 5 minutes. Cool to below 15°C using an ice-water bath. Adjust the pH to 6.0, add transglutaminase, the enzyme activity is 100U / g, and the dosage is 1 / 4 of the gelatin mass. Stir at room temperature and medium speed for 4 to 6 hours.

[0032] The microcapsules prepared under this condition had good spherical shape, smooth wall membrane and uniform particle size, which could well embed the core material cinnamaldehyde in the capsule. The microcapsule yield was 85.95% and the efficiency was 85.17% as measured by ethan...

Embodiment 2

[0034] Weigh 7.2g of gelatin and 0.8g of carboxymethyl cellulose, add 800ml of deionized water, stir and dissolve in a 60°C water bath. Weigh 16g of cinnamaldehyde, add it into the wall material solution, disperse and homogenize at high speed for 3 minutes. The speed of the disperser is 10000r / min. Stir at a constant temperature of 45°C with a stirring speed of 400r / min. 10% acetic acid solution was added to adjust the pH to 4.6, and the reaction was stirred for 5 minutes. Cool to below 15°C using an ice-water bath. Adjust the pH to 6.0, add transglutaminase, the enzyme activity is 100U / g, and the dosage is 1 / 4 of the gelatin mass. Stir at room temperature and medium speed for 4 to 6 hours.

[0035] Compared with Example 1, the amount of cinnamaldehyde embedded in the microcapsules prepared under this condition increased greatly. The microcapsule yield is 97.01% and the efficiency is 86.55% as measured by ethanol extraction-ultraviolet spectrophotometry.

Embodiment 3

[0037] Weigh 7 g of gelatin and 1 g of carboxymethyl cellulose, add 800 ml of deionized water, stir and dissolve in a water bath at 60°C. Weigh 8g of cinnamaldehyde, add it into the wall material solution, disperse and homogenize at high speed for 2 minutes. The speed of the disperser is 10000r / min. Stir at a constant temperature of 45°C with a stirring speed of 400r / min. 10% acetic acid solution was added to adjust the pH to 4.4, and the reaction was stirred for 5 minutes. Cool to below 15°C using an ice-water bath. Adjust the pH to 6.0, add transglutaminase, the enzyme activity is 100U / g, and the dosage is 1 / 4 of the gelatin mass. Stir at room temperature and medium speed for 4 to 6 hours.

[0038]The microcapsule yield was 81.6% and the efficiency was 73.26% as measured by ethanol extraction-ultraviolet spectrophotometry. The entrapment rate of microcapsules decreased when the ratio of gelatin / carboxymethylcellulose deviated from the optimum value.

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Abstract

The invention relates to a method for preparing a microcapsule taking a hydrophobic substance as a core material by a complex coacervation method. The method has the advantages of simple process and relatively lower cost, and the product has relatively higher encapsulation efficiency. The method comprises the following steps of: (1) weighing gelatin and carboxymethylcellulose in certain proportion, and stirring and dissolving the gelatin and the carboxymethylcellulose in hot water; (2) adding hydrophobic substance in certain mass ratio and dispersing the hydrophobic substance for 2 minutes at a high speed to form emulsion; (3) stirring the emulsion at the constant temperature of 45 DEG C, adjusting the pH of the emulsion to be 4.4 to 4.8 with a 10 percent ethylic acid and reacting the emulsion with the ethylic acid for 5 minutes; (4) cooling the emulsion until the temperature is below 15 DEG , adjusting the pH of the emulsion to be 6.0 and adding glutamine transaminase for solidification; and (5) filtering the mixed solution to obtain a wet microcapsule product, and freeze-drying or spray-drying the wet microcapsule product to obtain a dried microcapsule product.

Description

technical field [0001] The invention relates to the industries of food and flavors and fragrances, in particular to a technique for initiating composite coagulation reaction by adjusting pH, embedding core materials, and preparing microcapsules. The selected core material is a hydrophobic substance, which can be an oil-soluble essence, such as cinnamaldehyde, sweet orange oil, peppermint oil, etc., or a functional substance: such as fish oil, VE, etc. Background technique [0002] The main functions of microencapsulation are as follows: (1) Improve the physical properties of substances. After microencapsulation, liquid substances can become solid powders, which are convenient for storage and transportation, and are also convenient for adding to food. This is very important for hydrophobic substances that are usually oily and poorly dispersible; (2) to improve the stability of the substance, the microcapsule technology separates the core material from the surrounding environm...

Claims

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Application Information

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IPC IPC(8): C08L89/00C08L1/26C08K5/07C08K5/1545C08K5/00B01J13/10
Inventor 张晓鸣张海洋吕怡倪悦夏书芹贾承胜
Owner JIANGNAN UNIV
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