Microneedles array, die casting method for manufacturing microneedle array and die for manufacturing microneedle array

Abstract

The invention provides a microneedles array, a method for manufacturing the microneedles array and a die for manufacturing the microneedles array. The microneedles array comprises a base and a plurality of microneedles which are integrated with the base, wherein a liquid storage cavity is arranged in the base, and each microneedle are provided with micro-pinholes which are communicated with the liquid storage cavity; the microneedles array is made of plastics, composite materials, and ceramics or metal materials by injection molding; and each microneedle has at least one inclined surface which is inclined towards the central line of the microneedle, and the outlet of each micro-pinhole is positioned on at least one inclined surface, so that the end of the outlet of the microneedle forms a pinnacle part. The die specialized for the invention comprises an upper die, a middle die and a lower die, wherein the middle die and the lower die are provided with cavities for forming the microneedles; and the upper die and the middle die are provided with grooves for forming the base. The three-plate die of the invention can be used for conveniently manufacturing the microneedles array with the pinnacles. Since the stripping process in the injection molding method is carried out step by step, the method has the advantages of small die drawing resistance and low manufacturing cost.

Description

technical field [0001] The invention relates to a microneedle array with microneedle holes, a method for manufacturing the microneedle array and a special mold used in the method. Background technique [0002] The outermost skin layer of the human body, such as the stratum corneum, is the most beneficial biological barrier protection layer of the human body. The stratum corneum has excellent electrical insulation, which can effectively prevent external fluid from entering the subcutaneous tissue, and can also prevent the interstitial fluid from seeping out. At present, in the field of biomedicine, subcutaneous administration (that is, direct administration of medicinal liquid to the subcutaneous tissue below the stratum corneum) and collection of test samples from the subcutaneous interstitial fluid are becoming increasingly important for treating and diagnosing diseases. Both procedures require the use of needles or microneedle arrays that can penetrate the stratum corneum...

AI Technical Summary

Problems solved by technology

Because the material silicon of this kind of microneedle array is relatively expensive, this makes the cost of the microneedle array too high, and the microneedle array is a disposable medical product and cannot be reused. The practicability of the microneedle array of this kind of silicon material is poor

At the same time, the microneedle array of this silicon material is made by a photoetching process. The photoetching process is relatively complicated, and only a single product can be produced at a time. It is difficult to achieve mass production, and the process cost is high.

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