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Bone repairing material for personalized treatment

A repair material and bone repair technology, applied in the field of medical devices, can solve the problems of lack of individual matching and regenerative repair performance of bone defect regeneration materials, and achieve the effects of adjustable curing time, good plasticity, and improved aesthetics

Active Publication Date: 2010-09-01
SHENZHEN LANDO BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing implants for personalized treatment are almost all permanent replacement metal materials, which do not have regenerative repair properties
Various materials promoting bone defect regeneration lack individual matching

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of the high-strength bone repair material of embodiment 1 personalized treatment

[0038] (1) Scan the patient's affected area with CT first, reconstruct the three-dimensional image of the affected area, determine the shape and size of the bone repair material needed to repair the affected area, and then use rapid prototyping technology to manufacture molds with precise dimensions according to the size.

[0039] (2) Prepare calcium phosphate salt, α-CSH, and medical glass fiber according to the ratio of 8:1.5:0.5 and mix them uniformly to obtain a solid phase mixture. The phosphate calcium salt is composed of four salts of ACP, TTCP, β-TCP and HA, and the mass fraction ranges are 1%-5%, 40-45%, 35-41%, 10-20%, respectively.

[0040] (3), prepare the liquid phase of the sodium phosphate of 0.01mol / ml.

[0041] (4) The solid phase and the liquid phase are mixed and stirred rapidly to obtain an injectable bone. The ratio of solid phase to liquid phase is ...

Embodiment 2

[0044] The preparation of the bone repair material of embodiment 2 personalized treatment

[0045] (1) Scan the patient's affected area with CT first, reconstruct the three-dimensional image of the affected area, determine the shape and size of the bone repair material needed to repair the affected area, and then use rapid prototyping technology to manufacture molds with precise dimensions according to the size.

[0046] (2) Prepare calcium phosphate salt and α-CSH according to the ratio of 9.5:0.5 and mix them uniformly to obtain a solid phase mixture. The phosphate calcium salt is composed of four salts of ACP, TTCP, β-TCP and HA, and the mass fraction ranges are 1%-5%, 40-45%, 35-41%, 10-20%, respectively.

[0047] (3), prepare the liquid phase of the citric acid of 0.01mol / ml.

[0048](4) The solid phase and the liquid phase are mixed and stirred rapidly to obtain an injectable bone. The ratio of solid phase to liquid phase is 5:1

[0049] (5) Quickly add the paste-like...

Embodiment 3

[0051] Embodiment 3 Preparation of pie-shaped bone repair material

[0052] (1) Make precise size cake molds.

[0053] (2) Take calcium phosphate salt, α-CSH and carbon fiber according to a certain ratio, mix uniformly to obtain a solid phase mixture, the mass ratio ranges of calcium phosphate salt, α-CSH, and reinforcing fiber are respectively (6-9.5): (0.5-4): (0-2). The calcium phosphate salt is composed of four salts: TTCP, DCPD, α-TCP and HA, and the mass fraction ranges are 15-20%, 4-10%, 70-75% and 10-20%, respectively.

[0054] (3) Prepare a liquid phase of 0.1 mol / ml sodium hydrogen phosphate.

[0055] (4) Mix the solid phase and the liquid phase and stir rapidly to make a paste bone repair material. The ratio of solid phase to liquid phase ranges from 5 to 10:1.

[0056] (5) Quickly add the paste-like bone repair material to the mold in step (1), and solidify and form.

[0057] (6) Sterilization and packaging.

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Abstract

The invention relates to a bone repairing material for a personalized treatment. The material is prepared from a solid phase material which is prepared from a phosphoric acid calcium salt, alpha-hemihydrate calcium sulfate and reinforcing fibers and a liquid phase material which is prepared from one or more of citric acid, sodium phosphate, dibastic sodium phosphate, de-ionized water, physiological saline and blood of patient, wherein the volume ratio of the solid phase to the liquid phase is 5 to 10: 1. The bone repairing material can promote the regeneration of bone defects and can be processed into various complicated shapes and sizes according to the actual requirements of patients to meet the surgical requirements of the clinic personalized treatment or plastic operation.

Description

technical field [0001] The invention belongs to the field of medical equipment. More precisely, the present invention relates to a bone repair material capable of satisfying individualized treatment. technical background [0002] With the increase of bone defects and bone tumor cases, replacement or repair bone repair materials are more widely used in orthopedic clinics. Implants are temporarily shaped and assembled, and the shaped implants are difficult to obtain a satisfactory shape, and still do not match well with the affected area. At the same time, the operation time is prolonged, thereby affecting the surgical effect. If the bone repair materials needed for surgery can be customized for different patients before surgery, not only can the implant be well matched with the affected area, but also the operation time can be shortened. [0003] With the rapid development of materials science and computer-aided engineering, the processing technology of implants is becoming...

Claims

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Application Information

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IPC IPC(8): A61L27/40
Inventor 佘振定谭荣伟王明波
Owner SHENZHEN LANDO BIOMATERIALS
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