Imitating CT scanning mode multispectral time domain fluorescence molecular tomography measuring system

Abstract

The invention relates to the field of small animal molecular imaging, and provides an imitating CT scanning mode multispectral time domain fluorescence molecular tomography measuring system with ultrasensitive and high time-space resolution measurement performances so as to realize the high-quality multi-component multi-parameter imaging function. The imitating CT scanning mode multispectral time domain fluorescence molecular tomography measuring system comprises two picosecond semiconductor lasers, an optical fiber coupler, an incident optical fiber, an imaging cavity, a rotating platform, a receiving optical fiber, a motor driving filter wheel and a detection module, wherein the two picosecond semiconductor lasers and the optical fiber coupler are used for providing wavelength ultrashort laser required, the optical fiber coupler is used for coupling two same-frequency ultrashort laser pulses of different wavelengths into a bundle of laser according to fixed time interval, the incident optical fiber is used for projecting emergent laser of two or one of both picosecond semiconductor lasers onto an object, the imaging cavity and the rotating platform are used for realizing the imitating CT scanning mode, the receiving optical fiber is used for receiving reflective or transmitted laser from the object, and the detection module is used for receiving emergent light passing through corresponding filter pieces. The invention is mainly applied to the molecular imaging of small animals.

Description

technical field [0001] The invention relates to the field of molecular imaging of small animals, in particular to a time-domain fluorescence diffusion tomography system and a time-resolved optical tomography system for molecular imaging of small animals, and in particular to a multi-spectral time-domain fluorescence molecular tomography measurement system imitating CT scanning mode. Background technique [0002] Molecular imaging is a qualitative and quantitative study of biological processes in vivo at the cellular and molecular levels using imaging methods. It uses specific molecules in the body as the mechanism for imaging contrast, and reflects the biological processes in the body through imaging at the cellular or molecular level. Physiological and pathological changes. The advantages of molecular imaging can be summarized into three points: First, molecular imaging technology can turn complex processes such as gene expression and biological signal transmission into int...

AI Technical Summary

Problems solved by technology

[0004] The time-domain FMT implementation currently uses Time-Correlated Single PhotonCounting (TCSPC) technology, which is a discrete channel measurement technology with ultra-high sensitivity and reasonable time resolution; there is also time-gated image enhancement CCD camera (Time-gated Intensifier CCD camera) is a measurement technology with high spatial sampling rate, but its linearity and dynamic range are not high, and it has no advantage in sensitivity and time resolution compared with TCSPC technology

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