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New biological modification method of surface of crystalline silicon

A crystalline silicon and biological technology, which is applied in the field of biological modification of crystalline silicon surface, can solve the problems of poor biocompatibility of the coating, easy peeling off of the biological coating, and no intermediate transition layer, etc., to achieve good binding performance and improve biological Compatibility, effect of improving surface biological properties

Inactive Publication Date: 2010-07-28
HUNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The main purpose of the present invention is to provide a new method for biological modification of the surface of crystalline silicon to solve the problem that there is usually an obvious interface between the coating and the substrate of the biomedical silicon wafer due to composition differences and no intermediate transition layer. , the biological coating is easy to peel off, or the technical problem of poor biocompatibility of the coating due to the use of high temperature technology in the coating process, so as to realize the biological modification of the surface of crystalline silicon

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] i) Preparation of silicon-based silicate colloidal thin layer

[0051] First accurately weigh 3 grams of analytically pure sodium hydroxide, dissolve it in about 97 grams of distilled water in an atmospheric pressure vessel to form a strong alkaline solution, and the concentration of the strong alkali solution is about 3 wt%.

[0052] Then immerse the surface-clean single crystal silicon wafer in the prepared strong alkali solution of sodium hydroxide for 180 minutes. layer.

[0053] ii) Preparation of simulated body fluid (SBF)

[0054] First, according to the Na in 2000mL simulated body fluid (SBF) + The concentration is 138 mmol / L, K + at a concentration of 2 mmol / L, Mg 2+ At a concentration of 0.5 mmol / L, Ca 2+ at a concentration of 0.5 mmol / L, HCO 3 - The concentration is 3 mmol / L, SO 4 2- at a concentration of 0.1 mmol / L, HPO 4 2- The concentration is 0.5 mmol / L, respectively accurately weigh the corresponding amount of analytical grade sodium chloride,...

Embodiment 2

[0060] i) Preparation of silicon-based silicate colloidal thin layer

[0061] Accurately weigh 3 grams of analytically pure barium hydroxide, pass ammonia gas in a closed container, dissolve in about 70 grams of pure water to form an alkaline solution, and prepare a concentration of about 30 wt%.

[0062] Then immerse the surface-clean single crystal silicon wafer in the prepared alkaline solution in a closed container for 5 minutes. During the immersion process, the temperature is maintained at 150°C and the pressure is maintained at about 2MPa to obtain a silicon-based silicate colloidal thin layer.

[0063] ii) Preparation of simulated body fluid (SBF)

[0064] First, according to the Na in 2000mL simulated body fluid (SBF) + The concentration is 138 mmol / L, K + at a concentration of 2 mmol / L, Mg 2+ At a concentration of 0.5 mmol / L, Ca 2+ at a concentration of 0.5 mmol / L, HCO 3 - The concentration is 3 mmol / L, SO 4 2- at a concentration of 0.1 mmol / L, HPO 4 2- The...

Embodiment 3

[0070] i) Preparation of silicon-based silicate colloidal thin layer

[0071] Accurately weigh 250 grams of chemically pure grade potassium hydroxide and dissolve it in about 750 milliliters of deionized water to obtain a strong alkali solution with a concentration of about 25 wt%.

[0072] Then immerse the polycrystalline silicon with a clean surface in the prepared potassium hydroxide solution for 30 minutes. During the immersion process, the temperature of the strong alkali solution is kept at 70° C. and the pressure is normal pressure to obtain a silicon-based silicate colloidal thin layer.

[0073] ii) Preparation of simulated body fluid (SBF)

[0074] First, according to the Na in 2000mL simulated body fluid (SBF) + The concentration is 139 mmol / L, K + The concentration is 3 mmol / L, Mg 2+ At a concentration of 1.0 mmol / L, Ca 2+ at a concentration of 1.0 mmol / L, HCO 3 - The concentration is 3.5 mmol / L, SO 4 2- At a concentration of 0.2 mmol / L, HPO 4 2- The conce...

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Abstract

The invention discloses a new biological modification method of the surface of crystalline silicon. The method comprises the following steps: firstly dissolving an alkaline reagent in water to prepare an alkaline solution, and soaking the crystalline silicon in the prepared alkaline solution until the surface of the crystalline silicon forms a thin silicate colloid layer; then directly putting the crystalline silicon soaked by the alkaline solution in a simulated body fluid prepared in advance and soaking to form an osseous apatite bioactivity layer on the surface of the thin silicate colloid layer by inducement; and finally, repeatedly rinsing the prepared crystalline silicon with the thin silicate colloid layer and the osseous apatite bioactivity layer with water, and then drying to form a compound biological coating using the silicate as a transition layer and the osseous apatite as an outer layer on the surface of the crystalline silicon, namely a silicon-based silicate-osseous apatite compound biological coating is ultimately formed. The method has the advantages of convenient operation and low cost. Besides, the obtained biological coating on the surface of the crystalline silicon has favorable biological compatibility, and is difficult to fall off.

Description

technical field [0001] The invention belongs to the field of surface modification of crystalline silicon, in particular to a new method for biological modification of the surface of crystalline silicon. Background technique [0002] Due to its small size, high precision, and fast response, crystalline silicon is the key material for making microdevices such as biochips (Biochips), micro-sensors (Micro-sensors), and micro-electromechanical systems (MEMS). It has a wide range of applications in the fields of science and medicine. The micro-device with crystalline silicon as the core component can realize the rapid diagnosis and precise treatment of diseases, reduce the pain of patients, improve the efficiency and effect of medical treatment, and is expected to be used in clinical medicine soon. However, crystalline silicon itself is a biologically inert material. When it comes into direct contact with human tissue, it will produce adverse physiological reactions, such as infl...

Claims

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Application Information

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IPC IPC(8): C30B33/00
Inventor 吴振军李文生袁剑民王慧任艳群周小平
Owner HUNAN UNIV
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