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Streptococcus suis, Pasteurella multocida inactivated vaccine and preparation method thereof

A technology of Pasteurella and Streptococcus suis, which is applied in the direction of antibacterial drugs, pharmaceutical formulas, bacterial antigen components, etc., can solve problems such as waste, ineffective drug treatment, and antibiotic drug residues, and achieve the effect of easy operation and cost reduction

Active Publication Date: 2012-02-22
广东永顺生物制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing Pasteurella vaccine is a live bacterial vaccine, using live bacteria as the immunogen, there is a certain degree of shedding of the virus
In addition, due to the abuse of antibiotics, the emergence of drug-resistant strains leads to ineffective and wasteful drug treatment; the residue of antibiotic drugs makes meat animals face the problem of being unable to pass through when exporting

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] This product is selected from the pathogenic strain C55138 strain of Streptococcus equi subspecies zooepidemicus strain C55138, the streptococcus strain C55914 strain D group, the virulent strain C55949 streptococcus strain E group E and the Streptococcus suis type 2 HA9801 strain. Streptococcus capsular group A and capsular group B bacteria are inoculated in a suitable medium for culture, the culture is inactivated by formaldehyde solution, residual toxins are removed, and aluminum hydroxide gel is added to concentrate and prepare it. It is used to prevent streptococcus lamblia Various bacterial infections caused by group C, Streptococcus suis type 2, Pasteurella capsule group A and capsule B group bacteria. This includes several of the most important bacterial diseases that are currently prevalent. The strains used in the manufacture and inspection of this product are Streptococcus equi subspecies zooepidemic strain C55138, Group D streptococcus strain C55914, Strepto...

Embodiment 2

[0067] Example 2 Efficacy Research

[0068] With 30 healthy susceptible pigs, 2ml of the vaccine prepared in Example 1 was injected intramuscularly, containing 1 dose; 21 days later, each virulent strain was used for virulent challenge.

[0069] Streptococcus group C strain C55138

[0070] Select 5 immunized pigs, together with 3 control pigs with the same conditions, inject the lethal dose of virulent bacteria liquid of C55138 strain, and observe for 10 days. If more than 4 / 5 of the immunized pigs are protected and more than 4 / 5 of the control pigs die, they are qualified.

[0071] Streptococcus suis type 2 HA9801 strain

[0072] Select 5 immunized pigs, together with 5 control pigs with the same conditions, to attack with a lethal dose of HA9801 virulent strain, and observe for 10 days. More than 4 / 5 of the control group died, and more than 4 / 5 of the immunized group were protected, which was judged as qualified.

[0073] Group D strain C55914

[0074] Take 5 immunized pi...

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PUM

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Abstract

The invention provides an inactivated vaccine for Streptococcus suis and Pasteurella multocida, which can prevent Streptococcus suis infection caused by multiple different serogroup Streptococci and Pasteurella multocida caused by multiple different capsular serotypes. Infections caused by bacilli, clinically achieve the effect of multiple preventions with one injection, reduce costs, and there is no hidden danger of poison dispersion, safe and reliable. The invention also provides a preparation method of inactivated vaccines for streptococcus suis and pasteurella multocida.

Description

technical field [0001] The invention relates to the field of veterinary biological products, in particular to an inactivated vaccine for streptococcus suis and pasteurellosis multocida. Background technique [0002] Streptococcus suis and pasteurellosis are the two most important bacterial infectious diseases of pigs in my country. [0003] Streptococcus suis is a multi-symptom pig disease caused by a variety of streptococcal infections. It mainly causes symptoms such as septicemia, meningitis, pleurisy, tissue abscess, and arthritis in pigs. The mortality rate is high and it is seriously harmful when it is popular Pig farming. [0004] Since the 1960s in China, streptococcal suis has occurred successively in Guangxi, Guangdong, Fujian, Hunan, Jiangxi, Anhui, Jiangsu, Sichuan and other places. loss. According to statistics, the main serotype is Langley C group, followed by Langley D group and E group. In recent years, cases of Group R have been found in Guangdong, Jiangs...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/116A61K39/09A61K39/102A61P31/04
Inventor 杨球林旭埜张毓金游启有郭沈涛以体强
Owner 广东永顺生物制药股份有限公司
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