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Treatment or prevention of hypertensive disorders of pregnancy or fetal growth retardation

A technology for gestational hypertension and growth retardation, which can be used in cardiovascular system diseases, sexual diseases, medical preparations containing active ingredients, etc., and can solve problems such as difficult treatment.

Inactive Publication Date: 2010-07-14
PANTARHEI BIOSCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Another thing these lesions have in common is that they are currently difficult to treat

Method used

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  • Treatment or prevention of hypertensive disorders of pregnancy or fetal growth retardation
  • Treatment or prevention of hypertensive disorders of pregnancy or fetal growth retardation
  • Treatment or prevention of hypertensive disorders of pregnancy or fetal growth retardation

Examples

Experimental program
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Embodiment 1

[0047] To evaluate the acute dilatory response to estetrol in isolated human vasculature, the following studies have been performed.

[0048] Myometrial and subcutaneous arteries (diameter: 220 μm; length: 2-3 mm) were dissected from normal pregnant women undergoing planned caesarean section. The myometrial artery is present in the uterus and is a branch of the uterine artery.

[0049] Smokers and women with hypertension, diabetes mellitus, clinical manifestations of atherosclerosis (CHD, peripheral arterial disease, cerebrovascular disease), venous embolic disease, liver disease, unexplained vaginal bleeding, and personal or family history of breast cancer are excluded. None received HRT, other steroid hormones, or any medication known to affect lipoprotein metabolism or blood pressure.

[0050] The dissected arteries were mounted on a pressure myograph (LSI, USA). With PSS (mM: NaCl 119, KCl 4.7, CaCl 2 2.5, MgSO 4 1.17. NaHCO 3 25. KH 2 PO 4 1.18, EDTA 0.026 and glu...

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Abstract

The present invention relates to the use of a steroid in the manufacture of a pharmaceutical composition for use in the therapeutic or prophylactic treatment of a hypertensive disorder of pregnancy (HDP) or fetal growth retardation, said treatment comprising administering to a female mammal a steroid selected from the group consisting of: substances represented by the following formula (formula I) in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1 - 5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; no more than 3 of R1, R2, R3, R4 are hydrogen atoms; precursors of such substances; and mixtures of one or more of the aforementioned substances and / or precursors.

Description

technical field [0001] The present invention relates to the treatment or prevention of hypertensive disorder of pregnancy (HPD) or fetal growth retardation. Background technique [0002] What hypertensive disorders of pregnancy and fetal growth retardation have in common is that they are both associated with inadequate blood supply via the uterine arteries. Another thing these lesions have in common is that they are currently very difficult to treat. [0003] Examples of hypertensive disorders of pregnancy include hypertensive disorders selected from pre-eclampsia, eclampsia, HELLP syndrome, and gestational hypertension or pregnancy-induced hypertension. All of these hypertensive lesions are thought to be related to insufficient blood supply via the uterine arteries. [0004] WO 95 / 02408 teaches the combined use of progestins and nitric oxide synthase substrates in the treatment of preeclampsia and preterm birth. It is noted from this international patent application that...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/565A61P15/00
CPCA61K31/565A61P15/00A61P9/12
Inventor M·菲瑟H·J·T·科尔林格本宁克
Owner PANTARHEI BIOSCI
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