Application of cucurbitacin in preparation of medicament for treating cancer

A technology for the treatment of gentamidin, which is applied in the field of application of gentamidin in the preparation of drugs for the treatment of cancer, and can solve the problems of undiscovered reports on the application of gentamidin

Inactive Publication Date: 2010-07-07
KUNMING LONGJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] At present, there is no report on the application of porphyrin in anticancer drugs

Method used

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  • Application of cucurbitacin in preparation of medicament for treating cancer
  • Application of cucurbitacin in preparation of medicament for treating cancer
  • Application of cucurbitacin in preparation of medicament for treating cancer

Examples

Experimental program
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Embodiment 1

[0058] Embodiment 1: Take 5 kg of Luoguo bottom in Qiaojia County, Yunnan, grind it into medium powder, put it into a seepage container, add 24 times the amount of acetone to soak for 48 hours at 15-25 ° C, and then carry out percolation according to the Chinese Pharmacopoeia percolation method , recover the percolation liquid, mix the extract with an equal amount of silica gel, dry at 50-70°C, put it on a silica gel column, use chloroform: methanol as the eluent for gradient elution, and collect the eluate at a concentration of 3-5% methanol After recovery, the crude product can be obtained, and recrystallized several times with methanol to obtain columnar crystals with a melting point of 226-228°C and a purity of 98.98% by HPLC analysis. As shown in Figure 1, it was confirmed to be bilbacetin by four-spectrum analysis of ultraviolet, infrared, nuclear magnetic resonance and mass spectrometry.

[0059]Taking the above-mentioned pectin as a monomer component, according to the ...

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Abstract

The invention relates to new application of cucurbitacin in the preparation of a medicament for treating cancer and relates to application of the cucurbitacin in the preparation of a medicament for treating the laryngeal cancer.

Description

[0001] This application is a divisional application of 200610010906.7, the filing date of the original application is May 19, 2006, the application number is 200610010906.7, and the name of the invention is: the preparation method of pectin and its application in the preparation of drugs for treating cancer technical field [0002] The invention relates to a preparation method of the medicinal ingredient gentamicin and its new application in the preparation of medicines for treating cancer. Background technique [0003] Echobilisin is a mixture consisting of escobilin and escobilin. It was first isolated from the root of Hemsleya amalils Diels by Chen Weixin et al. (Acta Chemica Sinica, 1975, 33(1), 5). Hemsleya amalils was identified as 19-carbo-9β-formazan 23.24- cc dihydro-25-acetate, B identified as the 23,24-dihydro compound of cucurbitacin F (Ic), two new compounds, and the development of snow gallin tablets, which were recorded in 1974 According to the drug standard...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P35/00C07J9/00
Inventor 张人伟程惠佳樊献俄
Owner KUNMING LONGJIN PHARMA
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