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Antimicrobial artificial tooth root based on nanometer tube arrays and preparation method thereof

A nanotube array, artificial tooth root technology, applied in the direction of dental preparations, dentistry, dental prosthesis, etc., can solve the problem of not involving the surface preparation of metal substrates, and achieve the effect of not easy to produce drug resistance and high sterilization efficiency

Inactive Publication Date: 2011-09-07
江苏广达医材集团有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this preparation method can only prepare dispersed titanate structures, and does not involve the preparation of the surface of the metal substrate

Method used

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  • Antimicrobial artificial tooth root based on nanometer tube arrays and preparation method thereof
  • Antimicrobial artificial tooth root based on nanometer tube arrays and preparation method thereof
  • Antimicrobial artificial tooth root based on nanometer tube arrays and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) First choose pure titanium to process the artificial tooth root;

[0029] (2) Surface pretreatment of the artificial tooth root: After the surface is polished, it is washed with acetone, deionized water and absolute ethanol in sequence for 10-30 minutes, followed by HF and HNO 3 and water (volume ratio: 1:4:5) chemically polish for 20-40 seconds, rinse thoroughly with deionized water, and dry for use;

[0030] (3) Preparation of aqueous organic electrolyte solution: using ethylene glycol as a solvent, other active ingredients are: water 2vol% (volume percent), phosphoric acid 4vol% (volume percent), ammonium fluoride 0.3wt% (mass percent);

[0031](4) Preparation of titanium dioxide nanotubes by two-step anodization: the surface pretreated artificial tooth root is used as the anode, graphite or platinum sheet is used as the cathode, and the first anodization is carried out in an aqueous organic electrolyte solution. The specific anodization parameters are: voltage ...

Embodiment 2

[0036] (1) First choose titanium to process the artificial tooth root;

[0037] (2) Surface pretreatment of the artificial tooth root: After the surface is polished, it is washed with acetone, deionized water and absolute ethanol in sequence for 30-60 minutes, followed by HF and HNO 3 and water (volume ratio: 1:4:5) chemically polish for 40-60 seconds, then rinse thoroughly with deionized water, and blow dry with a hair dryer for use;

[0038] (3) Preparation of aqueous organic electrolyte solution: using ethylene glycol as a solvent, other active ingredients are: water 2vol% (volume percent), phosphoric acid 4vol% (volume percent), ammonium fluoride 0.5wt% (mass percent);

[0039] (4) Preparation of titanium dioxide nanotubes by two-step anodic oxidation: the surface pretreated artificial tooth root is used as the anode, graphite is used as the cathode, and the first anodic oxidation is carried out in an aqueous organic electrolyte solution. The specific anodic oxidation para...

Embodiment 3

[0044] (1) First choose pure titanium to process the artificial tooth root;

[0045] (2) Surface pretreatment of the artificial tooth root: After the surface is polished, it is washed with acetone, deionized water and absolute ethanol in sequence for 60-90 minutes, followed by HF and HNO 3 and water (volume ratio: 1:4:5) chemically polish for 60-80 seconds, then rinse thoroughly with deionized water, and blow dry with a hair dryer for use;

[0046] (3) Preparation of aqueous organic electrolyte solution: using ethylene glycol as a solvent, other active ingredients are: water 4vol% (volume percent), phosphoric acid 6vol% (volume percent), ammonium fluoride 0.5wt% (mass percent);

[0047] (4) Preparation of titanium dioxide nanotubes by two-step anodization: the surface pretreated artificial tooth root is used as the anode, graphite or platinum sheet is used as the cathode, and the first anodization is carried out in an aqueous organic electrolyte solution. The specific anodizat...

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Abstract

The invention relates to an antimicrobial artificial tooth root based on nanometer tube arrays and a preparation method thereof. A layer of silver doping sodium trititanate nanometer tube array layer with a tuber structure is arranged on the surface of a metal base layer of the artificial tooth root, and bone morphogenetic protein (BMP) is further loaded in the array layer. The preparation methodof the antimicrobial artificial tooth root based on the nanometer tube arrays comprises the following steps: adopting pure titanium or titanium alloy for processing the artificial tooth root; then, adopting the two-step anodic oxidation technology for obtaining a titanium dioxide nanometer tube array layer with the tubular structure on the surface of the pure titanium or titanium alloy artificialtooth root; next, converting the titanium dioxide nanometer tube array layer into the sodium trititanate nanometer tube array layer through an alkaline solution hydrothermal synthesis technology; next, doping the trace element of silver in the sodium trititanate nanometer tube array layer through solution impregnation ion exchange; and finally, loading the bone morphogenetic protein into the silver doping sodium trititanate nanometer tube array layer by a centrifugal load technology.

Description

technical field [0001] The invention relates to an antibacterial artificial tooth root based on a nanotube array surface and a preparation method thereof, in particular to an artificial tooth root with silver-doped sodium titanate nanotubes loaded with bone morphogenetic protein (BMP) on the surface and a preparation method thereof The invention belongs to the technical field of artificial tooth root materials. Background technique [0002] Dental implants are internationally recognized as the first choice for restoration of missing teeth. They are similar to real teeth in terms of function, shape, and use effects, and can be called "artificial teeth." Dental implants are composed of artificial tooth roots and porcelain crowns. Pure titanium and its alloys are widely used in the manufacture of artificial tooth roots for dental implants. However, ordinary titanium dioxide layers are not active enough to form a direct bond with bone, which sometimes translates into a lack of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/04A61K6/02
Inventor 储成林董寅生
Owner 江苏广达医材集团有限公司
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