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Extract composite preparation for treating oral ulcer and preparation method thereof

A technology of oral ulcers and extracts, applied in the field of extract combination preparations for the treatment of oral ulcers and its preparation

Active Publication Date: 2010-06-30
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This extraction method is too simple. Because each medicinal material has different characteristics, the active ingredients of the drug cannot be fully extracted by extracting the two medicinal materials together. However, the effective ingredients in the treatment of oral ulcers in sheep's ear chrysanthemum are effective flavonoids. Ingredient, flavonoids and saponins active ingredients such as liquiritigenin, isoliquiritigenin, glycyrrhizic acid, glycyrrhetinic acid and its derivatives in licorice have good effects on anti-inflammation, anti-infection, heat-clearing and detoxification, etc. Simple, high active ingredient content, good impurity removal and separation effect, suitable for large-scale production, and a process that saves production costs are the problems that the inventors need to solve

Method used

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  • Extract composite preparation for treating oral ulcer and preparation method thereof
  • Extract composite preparation for treating oral ulcer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] Embodiment 1 of the present invention: 50 parts of sheep ear chrysanthemum, 10 parts of licorice, 1 part of pearl, 0.5 part of borneol, prepared according to the following steps:

[0099] Step 1) Extract 6 times the amount of 40% ethanol with 6 times the amount of 40% ethanol for reflux extraction twice, each time for 0.5 hours, combine the extracts, filter, recover the ethanol from the filtrate to obtain an alcohol extract for later use; add 8 times the amount of water to decoct the dregs, filter After filtering, concentrate the filtrate, add 60% ethanol and let it stand overnight, filter, recover ethanol, combine the filtrate and the alcohol extract, put it on the purification resin column, discard the penetrating liquid, wash with a small amount of water, and then use 3 times the column volume of 60% ethanol For elution, pass through the column at 0.5ml per second, collect the eluent, recover ethanol, concentrate, vacuum dry, and pulverize to obtain the total flavonoi...

Embodiment 2

[0102] Embodiment 2 of the present invention: 100 parts of sheep ear chrysanthemum, 20 parts of licorice, 2 parts of pearls, 1 part of borneol, prepared according to the following steps:

[0103] Step 1) Extract 8 times the amount of 60% ethanol with reflux for 3 times, each time for 1 hour, combine the extracts, filter, recover the ethanol from the filtrate to obtain the alcohol extract for later use; add 10 times the amount of water to decoct the dregs of the herb , combined the decoction, filtered, concentrated the filtrate, added 70% ethanol to stand overnight, filtered, recovered the ethanol, combined the filtrate and the alcohol extract, put it on a polyamide column, discarded the penetrating liquid, washed with a small amount of water, and continued to use 4 times the column volume was eluted with 70% ethanol, 1ml per second was passed through the column, the eluate was collected, the ethanol was recovered, concentrated, dried in vacuum, crushed, and the total flavonoids...

Embodiment 3

[0106] Embodiment 3 of the present invention: 200 parts of sheep ear chrysanthemum, 40 parts of licorice, 4 parts of pearls, 2 parts of borneol, prepared according to the following steps:

[0107] Step 1) Extract chrysanthemum with 10 times the amount of 80% ethanol under reflux for 4 times, each time for 2 hours, combine the extracts, filter, recover the ethanol from the filtrate to obtain an alcohol extract for later use; add 12 times the amount of water to decoct the dregs for 3 times , combined the decoction, filtered, concentrated the filtrate, added 80% ethanol to stand overnight, filtered, recovered the ethanol, combined the filtrate and the alcohol extract, put it on the purification resin column, discarded the penetrating liquid, washed with a small amount of water, and continued to use Elute with 90% ethanol for 6 times the column volume, pass through the column at 2ml per second, collect the eluate, recover the ethanol, concentrate, vacuum dry, and pulverize to obtai...

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Abstract

The invention discloses an extract composite preparation for treating oral ulcer and a preparation method thereof. The extract composite preparation is prepared by mixing inula cappa, glycyrrhiza, pearl and borneol. In the invention, the inula cappa and the glycyrrhiza are respectively extracted, purified and refined to obtain inula cappa total flavonoid extract, glycyrrhiza total flavonoids and total saponin extract, and the composite preparation of the extracts is prepared fromthe inula cappa total flavonoid extract, the glycyrrhiza total flavonoids and the total saponin extract as well as pearl fine powder and borneol fine powder after crushing. Compared with the prior art, the invention respectively carries out purification, separation and concentration on extract solution, has enriched effective components, better keeps the characteristics of a Chinese herbal medicine compound preparation, efficiently lowers the side effects of medicines and enhances the curative effect, thereby enhancing and ensuring the quality of a product.

Description

technical field [0001] The invention relates to an extract combination preparation for treating oral ulcers and a preparation method thereof, belonging to the technical field of traditional Chinese medicine pharmacy. technical background [0002] Recurrent oral ulcers include recurrent aphthous ulcers, recurrent necrotizing mucosal periadenitis and herpetic ulcers. It is a relatively stubborn disease with a high incidence in oral mucosal diseases. Cold, hot, sour, sweet and other stimuli can cause pain Aggravated, painful, affecting language, diet and other health conditions. The new drug Pearl Dropping Pill developed by our company based on folk experience is a new preparation with good effect on treating oral ulcers, especially recurrent oral ulcers. The preparation is made of four flavors including sheep ear chrysanthemum, licorice, pearl, and borneol and appropriate amount of auxiliary materials. surface, etc.) ulcers of various sizes and irregular shapes, surrounding ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61K9/00A61K9/16A61K9/20A61K9/48A61P1/02A61K31/045A61K35/56A61K35/618
Inventor 窦啟玲
Owner GUIZHOU YIBAI PHARMA CO LTD
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