Pharmaceutical composition, injection and preparation method for treating porcine eperythrozoonosis

Abstract

A pharmaceutical composition for treating porcine eperythrozoonosis, an injection and a preparation method thereof. The pharmaceutical composition comprises imidazuron hydrochloride, doxycycline hydrochloride, non-steroidal anti-inflammatory drugs, glucocorticoids and salts thereof. The injection consists of the following components by weight percentage: 5-15% of imidazolium hydrochloride, 5-10% of doxycycline hydrochloride, 2-20% of non-steroidal anti-inflammatory drugs, 0.05% of glucocorticoids and their salts ~0.5%, magnesium chloride 0.5~5%, antioxidant 0.1~0.2%, metal complexing agent 0.01~0.05%, propylene glycol 5~20%, and the balance is water for injection. The product of the invention is characterized in that the composition of the prescription is reasonable, the physical and chemical properties of the medicine are stable, the dosage is accurate, the onset of action is fast, the maintenance time of the medicine effect is long, the bioavailability is high, the use is safe, and the curative effect is definite.

Description

technical field [0001] The invention relates to a veterinary drug, in particular to a pharmaceutical composition, an injection and a preparation method thereof for treating porcine eperythrozoonosis. Background technique [0002] Eperythrozoonosis is a disease characterized by decreased hematocrit, decreased hemoglobin concentration, leukocytosis, anemia, jaundice and fever, which are parasitic on the surface of red blood cells, plasma and bone marrow by Eperythrozoons. zoonoses. Eperythrozoon infection in pigs is generally a recessive infection, mostly under the action of stress factors. The clinical symptoms of sick pigs are mainly manifested as lack of energy, anorexia, elevated body temperature, anemia and jaundice. According to reports, the mortality rate of piglets can be as high as 90%. The disease can occur all year round, mainly in warm and humid seasons, and it is mostly of natural origin and has a strong prevalence. It can generally pass through 5 ways: digestiv...

AI Technical Summary

Problems solved by technology

According to many literature reports, tetracycline, oxytetracycline, doxycycline and arsine preparations have obvious inhibitory effects on it. The main drug for treating porcine Eperythrozoonosis is triazamidine, but the blood concentration of triazamidine is high after administration. The curative effect is better when used in the early stage of pig disease, the duration is short, the preventive effect is poor, and the curative effect on pigs with chronic infection or severe symptoms is not exact, and there is relapse in the cured pigs

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