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Method for preparing total salvianolic acid

A technology of total phenolic acids and lower alcohols of Salvia miltiorrhiza is applied in pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., and can solve the problems of poor stability of salvianolic acid, low alcohol precipitation efficiency, total phenolic acid and salvianolic acid. Problems such as low B content

Active Publication Date: 2010-06-09
TIANJIN TASLY ZHIJIAO PHARMA
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Problems solved by technology

[0004] The extraction method of total phenolic acid of salvia miltiorrhiza is mostly extracted with water first, then ethanol precipitation, and the method of macroporous resin purification, and the alcohol precipitation efficiency is low and the loss is large (Wang Zhiping, comparative study on resin adsorption and alcohol precipitation process of salvia miltiorrhiza extract, ion Exchange and Adsorption, 2003, 19(6): 554-560)
Yang Xiaoning et al. optimized and improved the original water extraction and alcohol precipitation process, but due to the poor stability of salvianolic acid, the transfer rate of water extracted salvianolic acid B was low, and the contents of total phenolic acid and salvianolic acid B were relatively low , respectively 51.62% and 30.97% (Study on the separation and purification process of total phenolic acids in Salvia miltiorrhiza, Yang Xiaoning et al., Chinese Herbal Medicine, 2007, 38(6): 843-846)

Method used

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  • Method for preparing total salvianolic acid
  • Method for preparing total salvianolic acid

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Embodiment 1

[0060] Danshen decoction pieces 1000 grams, 10000ml60% ethanol reflux extraction three times. The extracts were combined, concentrated to no alcohol, filtered, and the filtrate was passed through a 500 g polyamide column, washed with 10,000 ml of water, eluted with 10,000 ml of 95% ethanol, concentrated eluate, and dried. Obtain 40 grams of extract, the content of salvianolic acid B is 57%, and the total phenolic acid of Salvia miltiorrhiza is 86.6%.

Embodiment 2

[0062] Danshen decoction pieces 1000 grams, 6000m75% methanol extraction three times. The extracts were combined, concentrated to no alcohol, filtered, the filtrate passed through 2000 grams of AB-8 macroporous resin, washed with 15000 ml of water, eluted with 80% ethanol until complete, the eluate was concentrated, and spray-dried. Obtain 45 grams of extract, the content of salvianolic acid B is 64%, and the total phenolic acid of Salvia miltiorrhiza is 93.4%.

Embodiment 3

[0064] Danshen decoction pieces 1000 grams, 15000m75% ethanol countercurrent extraction. The extracts were combined, concentrated to no alcohol, filtered, and the filtrate passed through 2000 grams of D101 macroporous resin resin, rinsed with 15000 ml of 0% ethanol, eluted with 10000 ml of 50% ethanol, concentrated the eluate, and dried in vacuum at 60 degrees. 37 grams of the extract were obtained, the content of salvianolic acid B was 64%, and the total phenolic acids of Salvia miltiorrhiza were 89.5%.

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Abstract

The invention discloses a method for preparing total salvianolic acid. The method comprises the following steps of extracting Salvia miltiorrhiza by water-containing low-grade alcohol and extracting headspace polyamide or separating macroporous resin. The method has the advantages that the transferring rate of salvianolic acid B is high and can achieve 50-60%; the loss of active ingredients is low, the quality of the prepared product is good, the content of the total phenolic acid is equal to or greater than 80%, the content of salvianolic acid B is equal to or greater than 50%, and the therapeutic effect is obvious. The invention also discloses a preparation on pharmacy and a preparing purpose thereof.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a preparation method of salvianolic acid. Background technique [0002] Salvia miltiorrhiza is the dried rhizome of Salvia miltiorrhiza Bunge, a plant of the Labiatae family. It is one of the earliest and most widely used medicines in traditional medicine in my country. After long-term clinical application and modern medical research, it has a comprehensive understanding of its clinical effects and pharmacological effects know. Traditional Chinese medicine theory believes that Danshen can promote blood circulation and remove blood stasis; regulate menstruation and relieve pain; nourish blood and calm the nerves; cool blood and eliminate carbuncle. ; bruises; heat into the camp blood; restlessness; upset and insomnia; carbuncle sore swelling. Modern pharmacological studies have shown that Salvia miltiorrhiza has the functions of protecting against cerebral ischemia, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P1/04A61P1/08A61P1/16A61P1/18A61P3/10A61P9/00A61P11/00A61P13/12A61P19/08A61P25/06A61P25/28A61P27/02A61P43/00
Inventor 岳洪水
Owner TIANJIN TASLY ZHIJIAO PHARMA
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