Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cefuroxime sodium suspension powder injection

A technology of cefuroxime sodium and powder injection, which is applied in the field of a new dosage form of cefuroxime sodium, can solve problems such as poor stability, achieve low cost, improve bioavailability, and simple production process

Inactive Publication Date: 2010-06-09
HAINAN LINGKANG PHARMA CO LTD
View PDF2 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to provide a kind of stable cefuroxime sodium powder injection, specifically, through the combination of certain content surfactant, lyophilized support agent and active ingredient, adopt emulsification suspension technology to make cephalosporin of the present invention Suspension powder injection of Fuxin sodium has solved the problem of its poor stability and achieved satisfactory technical results

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cefuroxime sodium suspension powder injection
  • Cefuroxime sodium suspension powder injection
  • Cefuroxime sodium suspension powder injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Preparation of Suspension Powder Injection of Cefuroxime Sodium

[0032] Prescription (100 bottles): Cefuroxime Sodium 75g

[0033] Cholesterol 187.5g

[0034] Tween-80 37.5g

[0035] Mannitol 300g

[0036] Sodium chloride 75g

[0037] Preparation Process

[0038] (1) Add 187.5g of cholesterol and 37.5g of Tween-80 into 2200ml of water for injection, then add 75g of cefuroxime sodium and mix evenly, heat and stir in a water bath at 70°C until it melts;

[0039] (2) Keeping the above liquid at 70-90°C for 10 minutes with a tissue masher to shear and stir at a speed of 10,000 r / min to obtain a primary emulsion, and then circulate and emulsify it through a high-pressure homogenizer for 5 times to obtain an emulsion;

[0040] (3) Add 300g of mannitol and 75g of sodium chloride to the emulsion, dissolve, filter, subpackage, and freeze-dry to obtain cefuroxime sodium freeze-dried suspension powder injection...

Embodiment 2

[0048] Example 2 Preparation of Suspension Powder Injection of Cefuroxime Sodium

[0049]Prescription (100 bottles): Cefuroxime Sodium 100g

[0050] Cholesterol 500g

[0051] Tween-80 100g

[0052] Lactose 533g

[0053] Sucrose 267g

[0054] Preparation Process

[0055] (1) Add 500g of cholesterol and 100g of Tween-80 into 7500ml of water for injection, then add 100g of cefuroxime sodium and mix evenly, heat and stir in a water bath at 80°C until it melts;

[0056] (2) Keeping the above liquid at 70-90°C for 20 minutes with a tissue masher to shear and stir at a speed of 15000r / min to obtain a primary emulsion, and then circulate and emulsify it through a high-pressure homogenizer for 4 times to obtain an emulsion;

[0057] (3) Add 533g of lactose and 267g of sucrose to the emulsion, dissolve, filter, subpackage, and freeze-dry to obtain cefuroxime sodium suspension powder injection.

Embodiment 3

[0065] Example 3 Preparation of Suspension Powder Injection of Cefuroxime Sodium

[0066] Prescription (100 bottles): Cefuroxime Sodium 150g

[0067] Cholesterol 562.5g

[0068] Tween-80 112.5g

[0069] Trehalose 390g

[0070] Glycine 585g

[0071] Preparation Process

[0072] (1) Add 562.5g of cholesterol and 112.5g of Tween-80 into 6000ml of water for injection, then add 150g of cefuroxime sodium and mix evenly, heat and stir in a water bath at 90°C until it melts;

[0073] (2) Under the condition of keeping the above liquid at 70-90°C, shear and stir it with a tissue masher for 10 minutes at a speed of 13000r / min to obtain a primary emulsion, and then circulate and emulsify it through a high-pressure homogenizer for 5 times to obtain an emulsion;

[0074] (3) Add 390g trehalose and 585g glycine to the emulsion, dissolve, filter, subpackage, and freeze-dry to obtain cefuroxime sodium suspension powder injection.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a cefuroxime sodium suspension powder injection. The cefuroxime sodium suspension powder injection comprises the following components by weight part: 1 part of cefuroxime sodium, 2 to 10 parts of surfactant and 3 to 18 parts of lyoprotectants. The cefuroxime sodium suspension powder injection is characterized in that the surfactant is a combination of cholesterol and tween-80 in a weight ratio of 6:1-4:1. The cefuroxime sodium suspension powder injection is prepared unexpectedly by using the emulsification and suspension technologies through specific surfactant after freezing and drying and solves the problem of poor stability of the cefuroxime sodium.

Description

technical field [0001] The invention relates to a new dosage form of cefuroxime sodium, in particular to cefuroxime sodium suspension powder injection and a preparation method thereof. Background technique [0002] Cefuroxime sodium, its chemical name is: (6R,7R)-7-[2-furyl(methoxyimino)acetamido]3-carbamoyloxymethyl-8-oxo-5-thia -1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt, the molecular formula is: C 10 h 15 N 4 NaO 8 S, molecular weight: 446.37, structural formula: [0003] [0004] Cefuroxime sodium is a second-generation cephalosporin antibiotic, and its antibacterial activity against Gram-positive cocci is similar or slightly worse than that of the first-generation cephalosporins, but its β-lactamase against Staphylococcus and Gram-negative bacilli is comparable Stablize. The antibacterial activity against Staphylococcus aureus is worse than that of cefazolin, and 1-2 mg / L can inhibit all Staphylococcus aureus sensitive and resistant to penicill...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/19A61K31/546A61P31/04
Inventor 杨明贵
Owner HAINAN LINGKANG PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com