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Extraction method of genistein

A technology of genistein and an extraction method is applied in the field of extraction of genistein to achieve the effects of improving extraction purity, increasing extraction yield and increasing contact area

Active Publication Date: 2011-08-17
四川杨天药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of the above situation, the present invention will provide a new method for extracting genistein from the raw material Sophora japonica, to solve the problems including conventional extraction and ultrasonic extraction methods that have been used / reported at present

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0017] The extraction process proceeds in the following steps:

[0018] 1. The Sophora japonicus raw material is cleaned and dried in a conventional manner, crushed by a crusher, and passed through a 40-mesh sieve to obtain raw material granules of Sophora japonicus with a particle size of 40 mesh.

[0019] 2. Take 100 kg of 40-mesh Sophora japonica granules, add them to a mixing tank with 1000 liters of 85-90% ethanol, and stir with a stirrer at a speed of 30 r / min for 30 minutes to obtain a mixed solution.

[0020] 3. Turn on the liquid pump to make the fully mixed liquid material in the mixing tank pass through the reed whistle, vortex whistle, Hartmann whistle or other forms of hydrodynamic sound energy extraction devices at room temperature (the test results show basically the same ) Fluid dynamic sound energy extraction device, the measured sound pressure level is 235dB, the main frequency of sound waves is 1350Hz, and the treated solution enters the primary storage tank...

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Abstract

The invention relates to an extraction method of genistein. The method comprises the following steps: fully mixing the grinded raw material pagodatree pod with the grain size of 20-80 meshes and 80-95v% ethanol in the ratio of 1 / 8-1 / 15(w / v), pumping into a hydrodynamic force sonic energy generator, introducing sophoricoside to extraction solvent under the action of acoustic wave with the frequency of 1k-3kHz and the sound pressure level of 216-236dB which is generated by the flowing of the hydrodynamic force sonic energy generator, while performing further hydrolysis; after the solid-liquid separation, using ethanol to dissolve water-insoluble precipitate which is obtained by removing solvent in liquid part, after the ethanol dissolving process, performing silica gel column chromatography, using ethanol for elution, collecting the eluant, and removing solvent to obtain genistein. The method is a green extraction method without additional energy under the action of hydrodynamic force sound energy, the genistein can be obtained directly, the extraction process can be completed without any additional auxiliary component at room temperature, high purity extract can be obtained, and the damage of the effective ingredient can be avoided mostly. The treatment process is simple, the equipment is stable and reliable, the extraction equipment and the floor space are greatly reduced, andthe continuous operation can be realized, the unit capacity is high, the extraction time is greatly reduced, and the extraction cost is only 1 / 10-1 / 20 of that of the conventional method.

Description

technical field [0001] The invention relates to the extraction of natural plant components, in particular to a method for extracting genistein by using sound energy generated by fluid power. Background technique [0002] Genistein is a functional component with application value in the natural plant Sophora japonicus. At present, most of the extraction methods are to first obtain the genistein-4'-glucoside (sophorin) component by alcohol extraction, and then obtain genistein by acid hydrolysis. The extraction process takes a long time, and the high heating temperature will also cause the decomposition and loss of active ingredients. The more impurities contained in the extract will bring inconvenience to the subsequent processing and affect the extraction rate of active ingredients. [0003] In recent years, there have been research reports on the use of ultrasound in the extraction of plant natural components, and certain research results have been achieved. For example, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/36C07D311/40
Inventor 杨刚宜万海涛向杨
Owner 四川杨天药业有限公司
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