Method for extracting proanthocyanidin from pine bark by taking water as solvent

A technology of proanthocyanidins and pine bark, applied in the direction of organic chemistry, etc., can solve the problems of poor product safety, high production cost, complicated extraction process, etc., and achieve the effects of less loss, no chemical residue, and high extraction efficiency.

Inactive Publication Date: 2010-05-05
INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY
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  • Description
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Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the disadvantages of complicated extraction process, high production cost and poor product safety in the prior art, and propose a method for extracting proanthocyanidins from pine bark with water as a solvent, which has a simple process and high extraction rate. High, low production cost

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  • Method for extracting proanthocyanidin from pine bark by taking water as solvent
  • Method for extracting proanthocyanidin from pine bark by taking water as solvent

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Weigh 100g of clean, non-rotten and moldy pine bark, crush it to 60 mesh, add 1000mL of distilled water, and ultrasonically extract for 30min under the conditions of ultrasonic power 100W, frequency 20KHz, and temperature 50°C, repeat the extraction once, and combine The leaching solution was centrifuged for 20 minutes at 4000 rpm for 2 times to obtain a clarified leaching solution. The clarified extract is suction-filtered with a 0.45 μm microporous membrane to obtain a microfiltration permeate. The microfiltration permeate was ultrafiltered with a hollow fiber ultrafiltration membrane with a molecular weight cut-off of 100,000 Daltons. At room temperature, the reflux valve was adjusted to control the pressure to 0.1Mpa, and the ultrafiltration permeate was collected. The ultrafiltration permeate was concentrated with a roll-type nanofiltration membrane with a molecular weight cut-off of 200 Daltons. At room temperature, the reflux valve was adjusted to control the pre...

Embodiment 2

[0024]Weigh 10kg of clean, non-rotten and moldy pine bark, crush it to 40 mesh, add 100L deionized water, and ultrasonically extract for 40min under the conditions of ultrasonic power 1000W, frequency 40KHz, and temperature 45°C, and repeat the extraction once , combine the 2 extracts, and use a centrifuge for solid-liquid separation to remove solid impurities to obtain a clarified extract. The clarified extract is sent to the microfiltration device through a booster pump, and microfiltration is carried out with a 0.5μm tubular ceramic microporous filter membrane. The temperature of the feed liquid is controlled at about 35°C, and the return valve is adjusted to control the pressure to 0.6Mpa. liquid. The microfiltration permeate is sent to the ultrafiltration device through a booster pump, and ultrafiltration is performed with a hollow fiber ultrafiltration membrane with a molecular weight cut-off of 100,000 Daltons. The temperature of the feed liquid is controlled at about 3...

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Abstract

The invention discloses a method for extracting proanthocyanidin from pine bark by taking water as solvent. The method takes the pine bark as raw material and water as extraction solvent, utilizes ultrasonic wave technology for enhanced extraction to obtain proanthocyanidin leach liquor, uses the membrane separation technology of microfiltration for removing impurities, ultrafiltration purification and nanofiltration concentration for processing to obtain concentrated proanthocyanidin liquid, and finally obtains the proanthocyanidin product by vacuum or freeze drying. The method only takes the water as the extraction solvent, and utilizes the ultrasonic wave extraction technology and the membrane separation technology, so as to lead the whole technical process to be operated under the low temperature condition, thus not only effectively improving the extraction yield of active ingredients and ensuring bioactive substances not to be damaged, but also being safe and environment-friendly in production and having no residual chemical solvent on the product. Therefore, the proanthocyanidin is a natural and green product in the true sense, and the production method is very environment-friendly.

Description

technical field [0001] The invention relates to a method for extracting proanthocyanidins from pine bark, in particular to a method for extracting and separating proanthocyanidins from pine bark by using ultrasonic extraction technology and membrane separation technology, belonging to the technical field of natural product extraction. technical background [0002] Proanthocyanidins are polyphenolic compounds widely present in the plant kingdom, and are flavan-3-ol polymers formed by catechin or epicatechin through C-C bonds. Proanthocyanidin is a new type of high-efficiency antioxidant. Its antioxidant activity is 20 times that of vitamin C and 50 times that of vitamin E. It is the most powerful free radical scavenger found so far. It has direct or indirect effects on more than 70 diseases. It has a wide range of uses in medicine, food, health care, cosmetics and other fields. Pine bark is an important resource of proanthocyanidins, the source of raw materials is abundant, ...

Claims

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Application Information

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IPC IPC(8): C07D311/62
Inventor 郑光耀薄采颖宋强周维纯曹志庆
Owner INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY
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