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Method for preparing polyglycollide (PGA)-woven urethra scaffold for repairing urethral

A polyglycolide, tube stent technology, applied in medical science, prosthesis and other directions, can solve the problems of difficulty and failure of reconstructive surgery, and achieve the effects of good biocompatibility, prevention of invasion, and uniform passage.

Inactive Publication Date: 2012-11-07
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, long-segment or complicated repair and reconstruction have always been difficult problems, often requiring alternative materials, but clinically, the lack of ideal materials or improper selection often make reconstruction surgery difficult or even fail.

Method used

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  • Method for preparing polyglycollide (PGA)-woven urethra scaffold for repairing urethral
  • Method for preparing polyglycollide (PGA)-woven urethra scaffold for repairing urethral
  • Method for preparing polyglycollide (PGA)-woven urethra scaffold for repairing urethral

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The PGA braided urological stent can be prepared by the following method: use 48tex filament PGA (polyglycolide), which is 7 strands of multifilament, each strand of multifilament includes 12 single fibers, and uses a spindle type braiding machine with 16 spindles. Set it to about 6 to 7, select the gear ratio as 132 / 28, weave the yarn on the mandrel (diameter 3.05mm); at 95°C, heat set with the mandrel for 5 minutes, take it out and withdraw the PGA braided layer from the mandrel immerse in 2.5wt% chitosan slurry for 30 minutes, take it out and dry it naturally, put it in a freeze-drying environment at -50°C for 4 hours, cut it into 2cm sections, and serve.

[0026] The performance test of PGA braided urinary catheter is as follows:

[0027] 1. Measurement of porosity:

[0028] Among the various properties of the urinary tube, the porosity is undoubtedly one of the most important indicators.

[0029] The concept equivalent to porosity is "relative density", which is ...

Embodiment 2

[0046] The PGA braided urinary catheter can be prepared by the following method: adopt 48tex filament PGA (polyglycolide), which is 7 strands of multifilament, each strand of multifilament includes 12 single fibers, and uses a spindle type braiding machine with 16 spindles at a fixed speed. 6, the gear ratio is 132 / 28, and the yarn is braided on the mandrel (diameter 3.05mm); at 95°C, the mandrel is heat-set for 2 minutes, and the PGA braided layer is removed from the mandrel at 3.5 Immerse in wt% chitosan slurry for 30 minutes, take it out, dry it naturally, put it in a freeze-drying environment at -50°C for 4 hours, cut it into 2cm sections, and serve.

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Abstract

The invention relates to a polyglycollide PGA-woven urethra scaffold for repairing urethral. The scaffold is prepared by a two-dimensional and triaxial method. The method comprises the steps of: (1) taking 48tex PGA filament, weaving PGA on a core rod of which a gear ratio is 132 / 28, and setting the engine speed to between 6 and 7; (2) sizing at a temperature of between 90 and 105 DEG C for 5 minutes; and (3) removing a PGA weaving layer from the core rod, soaking the PGA weaving layer in 2.5 to 3 weight percent chitosan serum for 30 minutes, naturally airing the weaving layer, then placing the weaving layer in a freeze drying environment at 50 DEG C below zero for 4 hours, and obtaining the scaffold. The method for preparing the scaffold has the advantages of simpleness and low cost; andthe obtained woven urethra scaffold has the apparent morphology of a bionical urethra, and is thoroughly degraded.

Description

technical field [0001] The invention belongs to the field of preparation of braided urinary tubes, in particular to a preparation method of a polyglycolide (PGA) braided urinary tube bracket used for urethral repair. Background technique [0002] Congenital malformations of the urethra and urethral strictures and defects caused by various reasons are common diseases in urology. There are mainly congenital deformities, trauma or tumors that cause urethral damage, stenosis or defects, which often require repair and reconstruction of the urethra. The limited mucosal tissue brings considerable difficulties to the repair of the urethra. Liu Zhihe, Yue Jiujiu, Zhao Haitao et al. have already studied this in the research progress of urethral repair materials [J]. (Baotou Medicine, 2007, 31(2): 94-96). Among them, long-segment or complex repair and reconstruction has always been a difficult problem, often requiring alternative materials, but clinically, the lack of ideal materials...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/56
Inventor 陈南梁沈志静张佩华王文祖郯志清
Owner DONGHUA UNIV
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