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Cataplasm matrix and preparation method thereof

A poultice and matrix technology, applied in the field of poultice matrix and its preparation, can solve the problems of increasing energy consumption, perishability, and increasing the difficulty of storing the poultice, achieving long storage time, lasting water retention, and excellent peeling The effect of strength and tack

Inactive Publication Date: 2010-04-07
SUZHOU HENGXING MEDICAL MATERIAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the technical solution provided by the patent number CN00100628.2, polyvinyl alcohol and gelatin are used, but these two substances need to be heated and stirred continuously to slowly dissolve in water, especially polyvinyl alcohol needs to be heated to 70 This will not only increase the energy consumption but also complicate the technological process, which will increase the investment needlessly.
[0004] The patent No. CN02112475.2 also uses gelatin that needs to be heated and stirred to dissolve. Gelatin is a kind of high protein, and it will be easily corrupted if stored for a long time, which increases the difficulty of preservation of cataplasm; Aldehyde, this substance has a strong stimulating effect on the skin and mucous membranes, so there is a safety hazard

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The cataplasm matrix is ​​composed of the following ingredients mixed in weight ratio:

[0016] Partially neutralized sodium polyacrylate: 5.80 parts Glycol: 0.18 parts

[0017] EDTA disodium salt: 0.17 parts Glycerin: 20.00 parts

[0018] Cross-linked polyvinylpyrrolidone: 1.50 parts Polyvinylpyrrolidone: 1.25 parts

[0019] Tartaric acid: 0.30 parts Galantan: 0.35 parts

[0020] Polysorbate 80: 0.05 parts Purified water: 70.40 parts

Embodiment 2

[0022] The cataplasm matrix is ​​composed of the following ingredients mixed in weight ratio:

[0023] Partially neutralized sodium polyacrylate: 4.80 parts Glycol: 0.15 parts

[0024] EDTA disodium salt: 0.08 parts Glycerin: 21.60 parts

[0025] Cross-linked polyvinylpyrrolidone: 0.80 parts Polyvinylpyrrolidone: 2.50 parts

[0026] Tartaric acid: 0.57 parts Galantan: 0.50 parts

[0027] Polysorbate 80: 9.00 parts Purified water: 60.00 parts

Embodiment 3

[0029] The cataplasm matrix is ​​composed of the following ingredients mixed in weight ratio:

[0030] Partially neutralized sodium polyacrylate: 6.50 parts Glycol: 0.19 parts

[0031] EDTA disodium salt: 0.20 parts Glycerin: 22.00 parts

[0032] Cross-linked polyvinylpyrrolidone: 1.80 parts Polyvinylpyrrolidone: 1.72 parts

[0033] Tartaric acid: 0.19 parts Galantan: 0.35 parts

[0034] Polysorbate 80: 3.05 parts Purified water: 64.00 parts

[0035] The preparation method of the cataplasm in the above-mentioned embodiment is:

[0036] 1. Preparation of the oil phase: Accurately weigh the prescribed amount of glycerin, glycerol, disodium ethylenediaminetetraacetic acid, partially neutralized sodium polyacrylate, cross-linked polyvinylpyrrolidone, polysorbate 80, galadan , the above substances are placed in an open container, stirred and dispersed evenly, and then placed for use.

[0037] 2. Prepare the water phase: first accurately weigh the prescribed amount of tartaric ...

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PUM

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Abstract

The invention discloses a cataplasm matrix and a preparation method thereof. The matrix comprises part of neutralized sodium polyacrylate, dihydroxyaluminium, glycerol, disodium edetate dehydrate, polyvinylpyrrolidone, crospolyvinylpyrrolidone, dihydroxybutanedioic acid, DMDMH, polysorbate 80 and purified water. The preparation method comprises three steps, namely oil phase preparation, aqueous phase preparation and oil-aqueous phase mixing. The matrix has excellent peel strength and sticky consistency, features long water preservation, is difficult to fall off when being stuck on the skin and is free of residue after being uncovered.

Description

technical field [0001] The invention relates to a medical plaster base and a preparation method thereof, in particular to a cataplasm base and a preparation method thereof. Background technique [0002] The cataplasm is an external patch made of a water-soluble polymer as the matrix skeleton material. It is a plaster made by mixing the drug with a suitable hydrophilic matrix and coating it on the backing material. The backing, colloid , Anti-mucosal composition. It has a large drug loading capacity, strong moisturizing properties, and good compatibility with the skin; it can be repeatedly peeled off, and the administration can be terminated at any time; the dosage is accurate, the blood drug concentration is stable, and it can reduce toxic and side effects; there is no organic solvent pollution in industrial production, Meet environmental protection requirements. [0003] In the technical solution provided by the patent number CN00100628.2, polyvinyl alcohol and gelatin ar...

Claims

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Application Information

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IPC IPC(8): A61K47/32A61K47/34A61K47/24A61K47/18A61K47/12A61K47/10A61K9/70A61K47/26
Inventor 戴琳吴斌季金顺
Owner SUZHOU HENGXING MEDICAL MATERIAL
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