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Drug composite consisting of aconitum sinomontanum and lamiophlomis rotata, preparation method and application thereof

A composition and unique technology, applied in the field of pharmaceutical compositions and their preparation

Active Publication Date: 2010-03-31
GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no drug that combines the two drugs for analgesia and anti-inflammation. The combination of the two improves the efficacy of the drug and obtains an unprecedented effect

Method used

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  • Drug composite consisting of aconitum sinomontanum and lamiophlomis rotata, preparation method and application thereof
  • Drug composite consisting of aconitum sinomontanum and lamiophlomis rotata, preparation method and application thereof
  • Drug composite consisting of aconitum sinomontanum and lamiophlomis rotata, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0143] Example 1: Preparation of capsules

[0144] High Aconitum 20g Unique Flavor 80g

[0145] Extract the unique flavor medicinal materials twice with 30% ethanol, combine the extracts, recover the ethanol until there is no alcohol, continue to add water to twice the volume of the extract, centrifuge, take the supernatant and concentrate to dryness to obtain the unique flavor extract; Take aconitum and soak in 80% ethanol, release the soaking solution, and continue to percolate with ethanol, collect the ethanol solution, and recover the ethanol, dissolve the residue with hydrochloric acid, centrifuge, take the supernatant, add ammonia solution, adjust the pH value to 8 Then, it is extracted with chloroform, combined with the chloroform solution, and recovered to dryness to obtain the high aconitum extract; mix the above unique and high aconitum extracts, add conventional auxiliary materials, and follow the conventional process to prepare clinical or A pharmaceutically acceptable...

Embodiment 2

[0146] Example 2: Preparation of tablets

[0147] High Aconitum 80g Unique Flavor 30g

[0148] Extract the unique flavor medicinal materials 3 times with water, combine the extracts to obtain the unique flavor extract; take another aconitum soak with 40% ethanol, release the soaking solution, and continue to percolate with ethanol, collect the ethanol solution, and recover the ethanol. Dissolve the residue with hydrochloric acid, centrifuge, take the supernatant, add aqueous ammonia solution, adjust the pH to 12, extract with chloroform, combine the chloroform solution, and recover to dryness to obtain aconitum extract; The extracts of Aconitum vulgaris are mixed, conventional auxiliary materials are added, and clinically or pharmaceutically acceptable tablets are prepared according to conventional techniques.

Embodiment 3

[0149] Example 3: Preparation of oral liquid

[0150] High Aconitum 40g Unique Flavor 60g

[0151] Extract the unique flavor medicinal materials once with 40% ethanol, combine the extracts, recover the ethanol until there is no alcohol, continue to add water to 5 times the volume of the extract, centrifuge, take the supernatant and concentrate to dryness to obtain the unique flavor extract; Take aconitum and soak in 30% ethanol, release the soaking solution, and continue to percolate with ethanol, collect the ethanol solution, and recover the ethanol, dissolve the residue with hydrochloric acid, centrifuge, take the supernatant, add ammonia solution, and adjust the pH to 10 Then, it is extracted with chloroform, combined with the chloroform solution, and recovered to dryness to obtain the high aconitum extract; mix the above unique and high aconitum extracts, add conventional auxiliary materials, and follow the conventional process to prepare clinical or A pharmaceutically accepta...

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Abstract

The invention discloses a drug composite with analgesia and anti-inflammatory functions and a preparation method thereof. The drug composite comprises two raw material drugs--aconitum sinomontanum andlamiophlomis rotate and the preparation method comprises the following steps: preparing extract by extracting the raw material drugs with water or alcohol, concentrating, drying and other processes,combining extract, and adding common auxiliary material to prepare various common formulations. Experiments show that by jointly utilizing aconitum sinomontanum and lamiophlomis rotata, the dosage ofaconitum sinomontanum can be reduced, the analgesia effect is not reduced; and in anti-inflammatory experiments, aconitum sinomontanum and lamiophlomis rotata are jointly utilized, thereby increasingsingle drug effect and also having synergistic effect. Therefore, the drug composite of the invention has the analgesia and anti-inflammatory functions, is in particular suitable for pains caused by rheumatoid arthritis and malignant tumor, and has better clinical and market prospects.

Description

Technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition composed of aconitum and unique flavor for analgesia and anti-inflammatory, and a preparation method thereof. Background technique [0002] Aconitum is distributed in Xiaowutai Mountain in Yuxian County of Hebei, counties to the east of Riyue Mountain in Shanxi, Qinghai, Shaanxi, Gansu, Hubei, Sichuan, Guizhou and other provinces. Its roots are poisonous and used as medicine. It can reduce swelling and relieve pain, promote blood circulation and disperse blood stasis, expel wind, and cure fractures, rheumatic low back pain, boils, syphilis, heart palpitations, stomach pain, bruises and other symptoms. The compound has high safety and has strong analgesic effects, antipyretic and anti-inflammatory effects. Unique taste, bitterness, slightly cold. There is little poison. This species is a poisonous plant included in the Chin...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61P29/00
Inventor 雷菊芳李富银张铁军陈维武张樱山
Owner GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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