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Olprinone hydrochloric parenteral solution and method for preparing same

A technology for agricultural injections and injections, which is applied in the field of medicine, and can solve problems such as painstaking efforts, the use of pharmaceutical excipients, the weight of pharmaceutical excipients is not too suitable, and the properties of opprinone hydrochloride are not fully considered.

Inactive Publication Date: 2010-03-31
西安万隆制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The application number is 200610113480.8. The Chinese patent discloses the preparation of Oprinone Hydrochloride Injection and preparation precautions. Although this preparation solves the problem of preparation molding to a certain extent, it does not fully consider the properties of Oprinone Hydrochloride. The use of pharmaceutical excipients The amount and the weight of the pharmaceutical excipients are not very suitable, therefore, many medical workers are trying their best to study a more suitable prescription for Oprinone injection

Method used

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  • Olprinone hydrochloric parenteral solution and method for preparing same
  • Olprinone hydrochloric parenteral solution and method for preparing same
  • Olprinone hydrochloric parenteral solution and method for preparing same

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Embodiment 1

[0050] The invention relates to an injection of operprinone hydrochloride, which comprises operprinone hydrochloride and a pharmaceutical auxiliary material, wherein the pharmaceutical auxiliary material of the injection is a water-soluble excipient and an organic acid.

[0051] Among them, the pharmaceutical excipients are water-soluble excipients lactose and mannitol.

[0052] Wherein the pharmaceutical auxiliary material organic acid is citric acid.

Embodiment 2

[0054] The invention relates to an injection of operprinone hydrochloride, which comprises operprinone hydrochloride and a pharmaceutical auxiliary material, wherein the pharmaceutical auxiliary material of the injection is a water-soluble excipient and an organic acid.

[0055] Among them, the pharmaceutical excipients are water-soluble excipients glucose and mannitol.

[0056] Among them, the organic acid of pharmaceutical excipients is tartaric acid.

Embodiment 3

[0058] The invention relates to an injection of operprinone hydrochloride, which comprises operprinone hydrochloride and a pharmaceutical auxiliary material, wherein the pharmaceutical auxiliary material of the injection is a water-soluble excipient and an organic acid.

[0059] Among them, the pharmaceutical excipients are water-soluble excipients lactose and xylitol.

[0060] Wherein the pharmaceutical excipient organic acid is stearic acid.

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Abstract

The invention discloses olprinone hydrochloric parenteral solution and a method for preparing the same. In the parenteral solution, water-soluble excipient and organic acids serve as pharmaceutical adjuvant. In the parenteral solution in the invention, fewer sorts of pharmaceutical adjuvant are used, the dosage of the pharmaceutical adjuvant organic acids is greatly reduced, and on the basis of guaranteeing the quality of the preparation, the safety of the preparation is greatly improved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an oprinone hydrochloride injection and a preparation method thereof. Background technique [0002] Heart failure (Cardiac Dysfunction), also known as congestive heart failure (CHF), refers to a syndrome in which the cardiac output is reduced due to primary heart damage and cannot meet the needs of tissue metabolism under the condition of normal venous return . Clinically, pulmonary circulation and (or) systemic circulation stasis and tissue hypoperfusion are the main features. According to the speed of development of heart failure, it can be divided into two types: acute and chronic, with chronic in the majority. Current status of heart failure treatment: the current basic treatment of acute and chronic congestive heart failure is mainly the use of catecholamines and cardiac glycosides. Since the positive inotropic effect and the heart rate increasing effect of catecholamine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/437A61P9/04
Inventor 顾群金治刚米长江姜威
Owner 西安万隆制药股份有限公司
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