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Process for producing low molecular sodium heparin

A low-molecular-weight heparin sodium and production process technology, which is applied in the production process field of high-quality low-molecular-weight heparin sodium, can solve problems such as low product yield, unstable quality, and long production cycle, and achieve high purity, stable and reliable quality, and low cost. low effect

Inactive Publication Date: 2010-02-17
SICHUAN TIANCHENG BIOCHEM TECH
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  • Summary
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But these chemical cracking methods have a long production cycle, the product yield is only 80-85%, the process is complicated, and the quality is unstable

Method used

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Experimental program
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Embodiment 1

[0025] The production technology of low molecular weight heparin sodium of the present invention comprises the following steps:

[0026] ① Sodium heparin solution

[0027] Weigh 10kg of crude heparin sodium into a reaction pot, add 0.1kg of acetic acid and 70kg of distilled water, stir for 6-8 hours, and the temperature of the distilled water is 60°C;

[0028] ② Preparation of degradation solution

[0029] Add 0.2kg of sodium nitrite to the heparin sodium solution obtained in step ①, at a temperature of -5 to 30°C, and stir for 4-5 hours;

[0030] ③ Preparation of neutralizing solution

[0031] Add sodium hydroxide to the degradation solution obtained in step 2, and adjust the pH to 6.5-7.0;

[0032] ④Collect sediment

[0033] Add 25kg of ethanol to the neutralizing solution obtained in step 3., and collect the precipitate by precipitation;

[0034] ⑤ Preparation of crude low molecular weight heparin sodium

[0035] Add 3kg of acetone to the precipitate obtained in step ...

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Abstract

The invention discloses a process for producing low molecular sodium heparin by using raw sodium heparin as a raw material, which comprises the steps of: producing a sodium heparin solution; degradingthe solution; neutralizing the solution; collecting a precipitation; producing low molecular raw sodium heparin; producing low molecular fine sodium heparin and the like. The low molecular sodium heparin has the characteristics of rich sources of the raw material, high yield, stable and reliable quality, high purity, low cost, long curative effect, no toxic or side effect, simple process, convenient operation and no 'three wastes' discharge, has the effects of coagulation resistance, thrombosis resistance, tumor resistance, inflammation resistance, allergy resistance and the like and the efficiency of regulating blood lipid, has significant curative effect and wide application range, can be produced into injections, capsules, ointments and the like, is convenient for massive production, and is widely used for producing coagulation resistant low molecular sodium heparin.

Description

technical field [0001] The invention relates to a production process of biological medicines, in particular to a production process for preparing crude heparin sodium into high-quality low-molecular-weight heparin sodium. Background technique [0002] Heparin sodium is a collective name for a cluster of acidic mucopolysaccharide mixtures with different molecular weights. Its average molecular weight is 15000D. Heparin sodium salt and calcium salt are often used as medicines. It has various biological functions such as anticoagulant, antithrombotic, anti-inflammatory, anti-allergic, anti-viral and hypolipidemic, and it is also an effective drug for preventing and treating deep vein thrombosis, pulmonary embolism or other thrombosis. However, heparin sodium is accompanied by hemorrhage, thrombocytopenia, osteoporosis and other side effects in clinical application, and sometimes it can even cause fatal intracranial hemorrhage. In order to reduce the side effects of heparin sod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/10A61P7/02A61P35/00A61P29/00A61P31/00A61P37/08A61P3/06
Inventor 蔡天贵刘泰山蔡静蔡成良胡小翠蔡承儒蔡成英
Owner SICHUAN TIANCHENG BIOCHEM TECH
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