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Arginine-chitosan with high degree of substitution, preparation method and application thereof

A technology of high degree of substitution and chitosan, applied in the field of biomedical materials, can solve the problem of low degree of substitution, and achieve the effects of simple preparation method, easy large-scale production and mild reaction conditions

Inactive Publication Date: 2010-01-13
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some researchers have synthesized arginine-chitosan derivatives by using NHS / EDC as a catalyst (Liu WG et al. Journal of Materials Science: Materials in Medicine 2004; 15: 1199-1203.), only obtained a degree of substitution lower than 20.1% product

Method used

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  • Arginine-chitosan with high degree of substitution, preparation method and application thereof
  • Arginine-chitosan with high degree of substitution, preparation method and application thereof
  • Arginine-chitosan with high degree of substitution, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Put 6g of chitosan into a 250ml three-neck flask, then add 50ml of isopropanol to the bottle, and stir with an electric stirrer at a speed of 400r / min for 20min at room temperature to fully mix the two. 37.5 ml of 40% sodium hydroxide solution was injected into the three-necked flask five times with an interval of 5 minutes each time. After the resulting alkaline solution was stirred for 1 hour, a total of 6 g of monochloroacetic acid was also dropped into the bottle in five batches with an interval of 5 minutes between each batch. Subsequently, the mixed system was heated up to 60° C., and reacted at this temperature for 2 hours. After the reaction was completed, after the reaction system was cooled to room temperature, 5 ml of deionized water was added thereto, and then glacial acetic acid was added to adjust the pH to 7.0, and the mixed solution was filtered. Wash and filter with 70% to 90% ethanol solution to obtain a solid. The collected solid product was dried i...

Embodiment 2

[0032] Put 6g of chitosan into a 250ml three-neck flask, then add 50ml of isopropanol to the bottle, and stir with an electric stirrer at a speed of 400r / min for 20min at room temperature to fully mix the two. 37.5 ml of 40% sodium hydroxide solution was injected into the three-necked flask five times with an interval of 5 minutes each time. After the resulting alkaline solution was stirred for 1 hour, a total of 6 g of monochloroacetic acid was also dropped into the bottle in five batches with an interval of 5 minutes between each batch. Subsequently, the temperature of the mixed system was raised to 60° C., and reacted at this temperature for 4 hours. After the reaction was completed, after the reaction system was cooled to room temperature, 5 ml of deionized water was added thereto, and then glacial acetic acid was added to adjust the pH to 7.0, and the mixed solution was filtered. Wash and filter with 70% to 90% ethanol solution to obtain a solid. The collected solid pro...

Embodiment 3

[0036] Put 6g of chitosan into a 250ml three-neck flask, then add 50ml of isopropanol to the bottle, and stir with an electric stirrer at a speed of 400r / min for 20min at room temperature to fully mix the two. 37.5 ml of 40% sodium hydroxide solution was injected into the three-necked flask five times with an interval of 5 minutes each time. After the resulting alkaline solution was stirred for 1 hour, a total of 6 g of monochloroacetic acid was also dropped into the bottle in five batches with an interval of 5 minutes between each batch. Subsequently, the temperature of the mixed system was raised to 60° C., and reacted at this temperature for 6 hours. After the reaction was completed, after the reaction system was cooled to room temperature, 5 ml of deionized water was added thereto, and then glacial acetic acid was added to adjust the pH to 7.0, and the mixed solution was filtered. Wash and filter with 70% to 90% ethanol solution to obtain a solid. The collected solid pro...

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Abstract

The invention discloses arginine-chitosan with high degree of substitution, a preparation method and an application thereof, belonging to the field of biomedical material. The arginine-chitosan with high degree of substitution takes monochloroacetic acid as 'molecular arm', to ensure that arginine is efficiently and covalently bound on the free amino group or the free hydroxyl group of chitosan, and the electropositivity of the chitosan is obviously increased, therefore the antibiosis performance is enhanced. The material is derived from shells and shellfishes of arthropods, such as shrimps, crabs and insects, shells and gristles of mollusk, and cell walls of the cells of lower plant, fungus and alga. The arginine-chitosan with high degree of substitution has the advantages that the material preparation process is simple, and the material sources are rich. The property of the clinical burn and scald prevention susceptible fungus--staphylococcus aureus of the arginine-chitosan with high degree of substitution is better than that of unmodified chitosan, and is enhanced with the increase of the degree of substitution of arginine.

Description

technical field [0001] The invention belongs to the field of biomedical materials. Background technique [0002] Chitin is the second largest biomaterial in nature after cellulose, and it is widely found in the shells of arthropods such as shrimps, crabs, and insects, as well as in the cell walls of lower plant fungi and algae cells. Chitosan is the product of deacetylation of chitin treated with concentrated alkali. It is a natural polymer linear polysaccharide linked by glucosamine through β-1,4 glycosidic bonds. Its chemical name is β-(1,4 )-2-amino-deoxy-D-glucose. [0003] As a natural polymer, chitosan has excellent properties, such as good biocompatibility, non-toxicity, biodegradability, antibacterial, antifungal and antiviral, etc. In recent years, its anti-pathogenic bacteria properties have been extensively studied. Studies have shown that positively charged chitosan can inhibit the growth of bacteria by adsorbing on the surface of negatively charged bacteria, ...

Claims

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Application Information

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IPC IPC(8): C08B37/08A01N47/44A01P1/00
Inventor 张胜民肖波刘艺群万影
Owner HUAZHONG UNIV OF SCI & TECH
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