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Cetirizine hydrochloride liniment

A technology of cetirizine hydrochloride and glycerol, which is applied in the field of medicine, can solve the problems of unsatisfactory effect and long onset time, and achieve the effects of facilitating skin absorption, less skin irritation, and improving drug efficacy

Inactive Publication Date: 2010-01-13
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main reason for the analysis is that the effect is not very satisfactory, or the itching and tingling sensation after mosquito bites are severe for a short time, but they are relieved and disappear quickly, while oral drugs need a longer onset time

Method used

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  • Cetirizine hydrochloride liniment
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  • Cetirizine hydrochloride liniment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1 cetirizine hydrochloride liniment

[0041] Cetirizine Hydrochloride 1g

[0042] Glycerol 10g

[0043] Urea 0.2g

[0044] Benzalkonium Bromide 0.2g

[0045] Sodium chloride 0.1g

[0046] Add distilled water to 100ml, and adjust the pH value to 7.5 with an appropriate amount of 10% sodium hydroxide solution.

[0047] Under normal temperature and pressure, weigh 1g of cetirizine hydrochloride, dissolve it in an appropriate amount of distilled water, and then add it according to the proportion of each component in the prescription, that is, glycerin 10g, urea 0.2g, benzalkonium bromide 0.2g, sodium chloride 0.1g. Finally, add distilled water to 100ml, mix thoroughly, and adjust the pH to 7.5 with an appropriate amount of 10% sodium hydroxide solution.

Embodiment 2

[0048] Embodiment 2 cetirizine hydrochloride liniment

[0049] Cetirizine Hydrochloride 0.5g

[0050] Glycerol 5g

[0051] Urea 1g

[0052] Benzalkonium Bromide 0.1

[0053] Sodium chloride 0.9g

[0054] Add distilled water to 100ml, and adjust the pH value to 6.5 with an appropriate amount of 10% sodium carbonate solution.

[0055] Under normal temperature and pressure, weigh 0.5g of cetirizine hydrochloride, dissolve it in an appropriate amount of distilled water, and then add it according to the proportion of each component in the prescription, that is, glycerin 5g, urea 1g, benzalkonium bromide 0.1g, sodium chloride 0.9g. Finally, add distilled water to 100ml, mix thoroughly, and adjust the pH to 6.5 with an appropriate amount of 10% sodium carbonate solution.

Embodiment 3

[0056] Embodiment 3 cetirizine hydrochloride liniment

[0057] Cetirizine Hydrochloride 1g

[0058] Glycerol 37.8g

[0059] Urea 2g

[0060] 5% Benzalkonium bromide solution 2ml

[0061] Sodium chloride 0.9g

[0062] Add distilled water to 100ml, and adjust the pH value to 6.0 with an appropriate amount of 10% sodium hydroxide solution.

[0063] Under normal temperature and pressure, weigh 1 g of cetirizine hydrochloride, dissolve it in an appropriate amount of distilled water, and then add it according to the proportion of each component in the prescription, that is, 37.8 g of glycerol, 2 g of urea, and 5% benzalkonium Ammonium bromide solution 2ml, sodium chloride 0.9g. Finally, add distilled water to 100ml, mix thoroughly, and adjust the pH to 6.0 with an appropriate amount of 10% sodium hydroxide solution.

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Abstract

The invention belongs to the field of medicines, in particular to an external preparation of cetirizine hydrochloride, i.e., cetirizine hydrochloride liniment. Aiming at the defects of poor tissue infiltration capacity, limited dosage reaching target positions, and the like existed in the prior external preparation of cetirizine hydrochloride, the invention provides the cetirizine hydrochloride liniment with more remarkable antianaphylaxis healing effect by optimizing a prescription and screening more suitable accessories in an experiment process according to the physicochemical property of the cetirizine hydrochloride. The cetirizine hydrochloride liniment provided by the invention has simple preparation process and lower cost, little skin irritation and favorable treatment effect on partial skin redness and pruritus caused by mosquito bites.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to an external preparation-liniment of cetirizine hydrochloride. Background technique [0002] In recent years, due to the aggravation of environmental pollution, the abuse of chemicals, and the increase of external harmful substances, the incidence of skin allergies has been increasing year by year. When the external allergen enters the body, it activates the T lymphatic system and B lymphatic system, induces mast cell degranulation, releases allergic inflammatory mediators such as histamine and bradykinin, and produces allergic reactions, which often manifest as different types of allergic diseases. Such as allergic rhinitis, urticaria, skin redness, itching, red spots and asthma caused by allergens. Although the disease has no direct threat to life safety, it seriously affects the quality of life of patients due to its complex etiology and high incidence. Therefore, it is very important...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/495A61K47/18A61K47/10A61K47/02A61P37/08A61P17/00
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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