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Application of effective parts of Chinese dates and hawthorns in aspect of preparing medicine with activities of lowering blood fat and resisting oxidation

An effective site and blood lipid-lowering technology, applied in the field of blood lipid-lowering drugs, can solve the problems of single target, muscle toxicity, and high cost

Inactive Publication Date: 2010-01-06
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, although Western medicine has a certain effect on regulating blood lipids, it has side effects of varying degrees, and the target is single.
Currently recognized as the most effective and widely used Western medicine for lipid-lowering is statins, but they are expensive and have side effects such as liver and muscle toxicity

Method used

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  • Application of effective parts of Chinese dates and hawthorns in aspect of preparing medicine with activities of lowering blood fat and resisting oxidation
  • Application of effective parts of Chinese dates and hawthorns in aspect of preparing medicine with activities of lowering blood fat and resisting oxidation
  • Application of effective parts of Chinese dates and hawthorns in aspect of preparing medicine with activities of lowering blood fat and resisting oxidation

Examples

Experimental program
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Effect test

Embodiment 1

[0016] This example is the application of the blood lipid-lowering effective fraction of jujube and hawthorn in the preparation of blood lipid-lowering and antioxidant active drugs.

[0017] Antioxidant test in vitro:

[0018] Materials and Reagents:

[0019] Jujube polysaccharide (DW) and SC were prepared by the laboratory. Diphenyl bitter hydrazine free radical DPPH (Tokyo Chemical Industry Co., Ltd.); Trolox (Aldrich); ABTS [2,2'-hydrazine-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium Salt] (Fluka); BHT (Acros organics); Methanol, Sodium Acetate, FeCl 3 ·6H 2 O, glacial acetic acid, and potassium peroxodisulfate were all analytically pure.

[0020] Main instruments:

[0021] UV-2000 ultraviolet-visible spectrophotometer (Unico Shanghai Instrument Co., Ltd.), electronic balance (Mettler-Toledo Instrument Co., Ltd.), rotary evaporator (Tokyo Physical and Chemical), electric heating mantle (Beijing Zhongxing Weiye Instrument Co., Ltd. ), ultrasonic cleaner (Kunshan...

Embodiment 2

[0055] The blood lipid-lowering drug of this embodiment is jointly prepared from effective fractions of jujube and hawthorn. Among them, the extraction method of the effective part of jujube for lowering blood fat is as follows: remove the core of jujube, use 90% edible ethanol in a volume ratio of 5:1 with the mass of jujube to repeatedly cold-soak for 3 times, each time for 7 days, filter, and air-dry the filter residue , boil the filter residue with water three times, each time for 15 minutes, combine and concentrate the extracts, and dry to obtain the crude polysaccharide of jujube; then deproteinize the crude polysaccharide of jujube with 30% trichloroacetic acid, let it stand, centrifuge, and the supernatant is deproteinized with The lye is adjusted to PH=7, concentrated under reduced pressure, the concentrated solution is dialyzed against water, the concentrated solution after dialysis is added with absolute ethanol to make the alcohol content 70%, let stand, centrifuged...

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Abstract

The invention relates to a blood-fat-lowering effective part prepared by extracting the water soluble parts of Chinese dates and the alcohol soluble parts of hawthorns, namely, a blood-fat-lowering medicine comprising the blood-fat-lowering effective parts of the Chinese dates and the blood-fat-lowering effective parts of the hawthorns, which also relates to an application of the synergistic action of the blood-fat-lowering effective parts of the Chinese dates and the blood-fat-lowering effective parts of the hawthorns in the aspect of preparing a medicine with the activities of lowering blood fat and resisting oxidation. An experiment proves that the matching synergistic action of the blood-fat-lowering parts DW of Chinese dates and the blood-fat-lowering parts SC of hawthorns in the aspect of regulating hyperlipidemia is obvious, and the matching synergistic action of the blood-fat-lowering parts DW of the Chinese dates and the blood-fat-lowering parts SC of the hawthorns in the aspect of resisting lipid peroxidation is also more obvious. In-vivo and in-vitro experiments show that the DW, the SC and the combination of the DW and the SC have a certain antioxidation activity in vitro, can enhance the SOD level in the serum of a rat with the hyperlipidemia in vivo simultaneously, and lowers the MDA level, namely, the DW, the SC and the combination of the DW and the SC are consistent in vivo and in vitro; simultaneously, the DW and the SC have a positive synergistic action for resisting oxidation in vitro, have the positive synergistic action for resisting lipid peroxidation and regulating blood fat in vivo and are also consistent in vivo and in vitro. Therefore, the SC and the DW have the synergic function for regulating blood fat and resisting oxidation.

Description

technical field [0001] The invention relates to a blood lipid-lowering effective part prepared by extracting the water-soluble part of jujube and the alcohol-soluble part of hawthorn. The application of the blood lipid-lowering effective fraction and the blood-lipid-lowering effective fraction of hawthorn synergistically in the preparation of blood lipid-lowering and antioxidant active drugs. Background technique [0002] Jujube is the ripe fruit of the rhamnaceae plant jujube (ziziphus Jujube Mill), which is warm in nature, sweet in taste and non-toxic. It is mainly used to treat evil qi in trusted subordinates, tranquilize the middle, nourish the temper, calm the stomach qi, unblock the nine orifices, help the twelve meridians, replenish less qi, less body fluid, insufficiency in the body, severe shock and heavy limbs, and hundreds of medicines, long-term use to lighten the body and prolong the body. Jujube is delicious and sweet, and its sugar content ranks first in all ...

Claims

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Application Information

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IPC IPC(8): A61K36/734A61P3/06
Inventor 康文艺李晓梅郭曙光
Owner HENAN UNIVERSITY
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